Results 111 to 120 of about 83,408 (297)

EFP1 is an ER stress-induced glycoprotein which interacts with the pro-apoptotic protein Par-4 [PDF]

, 2009
We have isolated the rat ortholog of EFP1 (EF-hand binding protein 1) as a novel interaction partner of the pro-apoptotic protein Par-4 (prostate apoptosis response-4).
Appel, Sarah, Boosen, Meike, Koplin, Ansgar, Maertens, Barbara, Preuss, Ute, Vetterkind, Susanne   +5 more
core   +1 more source

Expression of active human sialyltransferase ST6GalNAcI in Escherichia coli [PDF]

, 2009
Georgios Skretas, Sean Carroll, and George Georgiou are with the Department of Chemical Engineering, University of Texas at Austin, Austin, TX 78712, USA -- George Georgiou is with the Department of Biomedical Engineering, University of Texas at Austin ...
Carroll, Sean, DeFrees, Shawn, Georgiou, George, Johnson, Karl F., Schwartz, Marc F., Skretas, Georgios   +5 more
core   +3 more sources

A substrate-driven allosteric switch that enhances PDI catalytic activity

Nature Communications, 2016
Protein Disulfide Isomerase (PDI) is a prothrombotic, multidomain enzyme with separate substrate binding and catalytic domains. Here, the authors identify a new class of compounds that target the PDI substrate binding site, inducing a conformational ...
Roelof H. Bekendam, Pavan K. Bendapudi, Lin Lin, Partha P. Nag, Jun Pu, Daniel R. Kennedy, Alexandra Feldenzer, Joyce Chiu, Kristina M. Cook, Bruce Furie, Mingdong Huang, Philip J. Hogg, Robert Flaumenhaft   +12 more
doaj   +1 more source

Stress in dipteran insects mass‐reared for sterile insect technique applications

Insect Science, EarlyView.
The connections between biotic and abiotic stress affecting mass‐reared dipteran insects and the associated stress and immunological responses. Numbers indicate the order in which the topics are discussed in this review. Abstract Stress may be viewed as the disturbance of homeostasis of an organism.
Caroline K. Mirieri, Vera I.D. Ros, Adly M.M. Abd‐Alla, Monique M. van Oers   +3 more
wiley   +1 more source

Crystal Structure of Imaginal Disc Growth Factor-2 [PDF]

, 2002
Imaginal disc growth factor-2 (IDGF-2) is a member of a recently described family of Drosophila melanogaster-soluble polypeptide growth factors that promote cell proliferation in imaginal discs.
Llera, Andrea Sabina, Mariuzza, Roy A., Tormo, José, Varela, Paloma F.   +3 more
core   +1 more source

Kinetic-based trapping by intervening sequence variants of the active sites of protein-disulfide isomerase identifies platelet protein substrates

Journal of Biological Chemistry, 2017
Thiol isomerases such as protein-disulfide isomerase (PDI) direct disulfide rearrangements required for proper folding of nascent proteins synthesized in the endoplasmic reticulum.
Jack D. Stopa, K. Baker, S. Grover, R. Flaumenhaft, B. Furie   +4 more
semanticscholar   +1 more source

A Comprehensive Multiomics Signature of Doxorubicin‐Induced Cellular Senescence in the Postmenopausal Human Ovary

Aging Cell, EarlyView.
Explants of human postmenopausal ovarian cortex and medulla were treated with doxorubicin for 24 h followed by culture for up to 10 days in doxorubicin‐free medium. Single nuclei sequencing and proteomics revealed an unbiased signature of ovarian senescence driven by epithelial cells in the cortex and stromal cells in the cortex and medulla ...
Pooja Raj Devrukhkar, Mark A. Watson, Bikem Soygur, Fei Wu, Joanna Bons, Hannah Anvari, Tomiris Atazhanova, Nicolas Martin, Tommy Tran, Kevin Schneider, Jacob P. Rose, Daniel Winer, Elisheva Shanes, Mary Ellen G. Pavone, Judith Campisi, David Furman, Simon Melov, Birgit Schilling, Francesca E. Duncan   +18 more
wiley   +1 more source

Engineered Pathways for Correct Disulfide Bond Oxidation [PDF]

, 2011
Correct formation of disulfide bonds is critical for protein folding. We find that cells lacking protein disulfide isomerases (PDIs) can use alternative mechanisms for correct disulfide bond formation.
Bardwell, James C. A., Ren, Guoping
core   +2 more sources

Protein Disulfide Isomerase Modulates the Activation of Thyroid Hormone Receptors

Frontiers in Endocrinology, 2019
Thyroid hormone receptors (TRs) are responsible for mediating thyroid hormone (T3 and T4) actions at a cellular level. They belong to the nuclear receptor (NR) superfamily and execute their main functions inside the cell nuclei as hormone-regulated ...
Jessica L. O. Campos, Jessica L. O. Campos, Tabata R. Doratioto, Tabata R. Doratioto, Natalia B. Videira, Natalia B. Videira, Helder V. Ribeiro Filho, Helder V. Ribeiro Filho, Fernanda A. H. Batista, Juliana Fattori, Nathalia de C. Indolfo, Nathalia de C. Indolfo, Marcel Nakahira, Marcio C. Bajgelman, Aleksandra Cvoro, Francisco R. M. Laurindo, Paul Webb, Ana Carolina M. Figueira   +17 more
doaj   +1 more source

A cellular model of TDP‐43 induces phosphorylated TDP‐43 aggregation with distinct changes in solubility and autophagy dysregulation

The FEBS Journal, EarlyView.
TDP‐43 protein plays a pathological role in sporadic and familial amyotrophic lateral sclerosis (ALS). Here, we developed a cellular model overexpressing TDP‐43 with three mutations linked to familial ALS, termed ‘3X‐TDP‐43’. Mutant 3X‐TDP‐43 expression showed deficits in autophagy flux and colocalization with stress granules.
Matthew B. Dopler, Muhammad I. Abeer, Sanaz Arezoumandan, Keyshawn Cox, Tyler L. Petersen, Esther H. Daniel, Carlton L. Cannon III, Angelica Bautista, Kennedy D. Blancher, Alysia M. Bland, Kylie J. Bond, Dominque A. Davis, Jessica M. Francois, Eliana J. McCray, Justin M. Morgan, Jessica L. Pulliam, Zymir A. Robinson, Mykia J. Taylor, James A. Dowell, Nigel J. Cairns, Michael A. Gitcho   +20 more
wiley   +1 more source