Results 151 to 160 of about 83,408 (297)

Folding of peptides and proteins: role of disulfide bonds, recent developments

Biomolecular Concepts, 2013
Disulfide-containing proteins are ideal models for studies of protein folding as the folding intermediates can be observed, trapped, and separated by HPLC during the folding reaction.
Hidaka Yuji, Shimamoto Shigeru
doaj   +1 more source

Epidermal proteomics demonstrates Elafin as a psoriasis‐specific biomarker and highlights increased anti‐inflammatory activity around psoriatic plaques

Journal of the European Academy of Dermatology and Venereology, Volume 39, Issue 7, Page 1324-1335, July 2025.
Epidermal sampling of lesional, perilesional and non‐lesional skin from psoriasis and eczema patients as well as healthy skin was used to perform an in depth proteomic analysis. IL‐36γ known to be expressed in lesional psoriasis skin was outperformed by the protease inhibitor Elafin as a disease‐specific epidermal biomarker.
Anna Berekmeri, Tom Macleod, Isabel Hyde, Gregor Jan Ojak, Caroline Mann, Daniela Kramer, Martin Stacey, Miriam Wittmann   +7 more
wiley   +1 more source

Distinct roles and actions of protein disulfide isomerase family enzymes in catalysis of nascent-chain disulfide bond formation

iScience, 2021
Summary: The mammalian endoplasmic reticulum (ER) harbors more than 20 members of the protein disulfide isomerase (PDI) family that act to maintain proteostasis.
Chihiro Hirayama, Kodai Machida, Kentaro Noi, Tadayoshi Murakawa, Masaki Okumura, Teru Ogura, Hiroaki Imataka, Kenji Inaba   +7 more
doaj  

Quercetin-3-rutinoside Inhibits Protein Disulfide Isomerase by Binding to Its b′x Domain*

Journal of Biological Chemistry, 2015
Background: Quercetin-3-rutinoside is an inhibitor of protein disulfide isomerase, a potential target for antithrombotic therapy. Results: Quercetin-3-rutinoside induces a compact conformation in PDI and binds to PDI with an IC50 of about 10 μm ...
Lin Lin, Srila Gopal, Anish Sharda, F. Passam, S. Bowley, Jack D. Stopa, Guangpu Xue, C. Yuan, B. Furie, R. Flaumenhaft, Mingdong Huang, B. Furie   +11 more
semanticscholar   +1 more source

Tmx2 Maintains Mitochondrial Function to Support Preimplantation Embryogenesis

The FASEB Journal, Volume 39, Issue 11, 15 June 2025.
TMX2 is a member of the thioredoxin‐related transmembrane protein family. It exhibits specific expression in mouse preimplantation embryos, and its subcellular localization is closely associated with mitochondria. Knockdown of Tmx2 in embryos results in a reduction in mitochondrial number, a decline in mitochondrial membrane potential, and an elevation
Shangrong Zhang, Qing Liu, Siyu Wang, Xiaoyu Zhang, Dingmei Qin, Ruisong Bai, Ji Chen, Zijian Ma, Zhipeng Lin, Yuheng Bi, Huan Liu, Aoxue Sun, Zhongzhi Mo, Hongcheng Wang, Xiaoqing Wu, Yong Liu   +15 more
wiley   +1 more source

The Associations between Immunological Reactivity to the Haptenation of Unconjugated Bisphenol A to Albumin and Protein Disulfide Isomerase with Alpha-Synuclein Antibodies

Toxics, 2019
Patients with Parkinson’s disease (PD) have increased susceptibility to bisphenol A (BPA) exposure since they have an impaired biotransformation capacity to metabolize BPA.
Datis Kharrazian, Martha Herbert, Aristo Vojdani   +2 more
doaj   +1 more source

Review

, 2020
The chalcogen elements oxygen, sulfur, and selenium are essential constituents of side chain functions of natural amino acids. Conversely, no structural and biological function has been discovered so far for the heavier and more metallic tellurium ...
Moroder, L., Musiol, H.
core   +1 more source

Protein disulfide isomerase may facilitate the efflux of nitrite derived S-nitrosothiols from red blood cells

Redox Biology, 2013
Protein disulfide isomerase (PDI) is an abundant protein primarily found in the endoplasmic reticulum and also secreted into the blood by a variety of vascular cells.
Vasantha Madhuri Kallakunta, Anny Slama-Schwok, Bulent Mutus   +2 more
doaj   +1 more source

Enolase 1 (ENO1) and protein disulfide-isomerase associated 3 (PDIA3) regulate Wnt/β-catenin-driven trans-differentiation of murine alveolar epithelial cells

Disease Models & Mechanisms, 2015
The alveolar epithelium represents a major site of tissue destruction during lung injury. It consists of alveolar epithelial type I (ATI) and type II (ATII) cells.
K. Mutze, S. Vierkotten, J. Milošević, O. Eickelberg, M. Königshoff   +4 more
semanticscholar   +1 more source

Quercetin-3-Rutinoside Blocks the Disassembly of Cholera Toxin by Protein Disulfide Isomerase

Toxins, 2019
Protein disulfide isomerase (PDI) is mainly located in the endoplasmic reticulum (ER) but is also secreted into the bloodstream where its oxidoreductase activity is involved with thrombus formation.
Jessica Guyette, Patrick Cherubin, Albert Serrano, Michael Taylor, Faisal Abedin, Morgan O’Donnell, Helen Burress, Suren A. Tatulian, Ken Teter   +8 more
doaj   +1 more source