Results 41 to 50 of about 86,419 (320)

Analysis of the interaction of calcitriol with the disulfide isomerase ERp57 [PDF]

, 2016
Calcitriol, the active form of vitamin D3, can regulate the gene expression through the binding to the nuclear receptor VDR, but it can also display nongenomic actions, acting through a membrane- associated receptor, which has been discovered as the ...
Altieri, Fabio, Cervoni, Laura, Chichiarelli, Silvia, Eufemi, Margherita, Gaucci, Elisa, Grillo, Caterina, Nittari, Giulio, Raimondo, Domenico   +7 more
core   +1 more source

Targeting protein disulfide isomerase with the flavonoid isoquercetin to improve hypercoagulability in advanced cancer.

JCI Insight, 2019
BACKGROUND Protein disulfide isomerase (PDI) is a thiol isomerase secreted by vascular cells that is required for thrombus formation. Quercetin flavonoids inhibit PDI activity and block platelet accumulation and fibrin generation at the site of a ...
J. Zwicker, Benjamin L. Schlechter, Jack D. Stopa, H. Liebman, A. Aggarwal, M. Puligandla, Thomas Caughey, K. Bauer, N. Kuemmerle, E. Wong, T. Wun, M. Mclaughlin, M. Hidalgo, D. Neuberg, B. Furie, R. Flaumenhaft   +15 more
semanticscholar   +1 more source

Binding of Host Cell Surface Protein Disulfide Isomerase by Anaplasma phagocytophilum Asp14 Enables Pathogen Infection

mBio, 2020
Anaplasma phagocytophilum infects neutrophils to cause granulocytic anaplasmosis, an emerging potentially fatal disease and the second-most common tick-borne illness in the United States. Treatment options are limited, and no vaccine exists.
Ryan S. Green, Waheeda A. Naimi, Lee D. Oliver, Nathaniel S. O’Bier, Jaehyung Cho, D. Conrad, Rebecca K. Martin, R. Marconi, J. Carlyon   +8 more
semanticscholar   +1 more source

Immunoproteomic to identify antigens in the intestinal mucosa of Crohn's disease patients. [PDF]

PLoS ONE, 2013
Incidences of Crohn disease (CD) have increased significantly in the last decade. Immunoproteomics are a promising method to identify biomarkers of different diseases. In the present study, we used immunoproteomics to study proteins of intestinal mucosal
Zheng Zhou, Haiyan Liu, Guosheng Gu, Gefei Wang, Wenyong Wu, Changle Zhang, Jianan Ren   +6 more
doaj   +1 more source

Participation of the endoplasmic reticulum protein chaperone thio-oxidoreductase in gonadotropin-releasing hormone receptor expression at the plasma membrane

Brazilian Journal of Medical and Biological Research, 2009
Chaperone members of the protein disulfide isomerase family can catalyze the thiol-disulfide exchange reaction with pairs of cysteines. There are 14 protein disulfide isomerase family members, but the ability to catalyze a thiol disulfide exchange ...
W. Lucca-Junior, J.A. Janovick, P.M. Conn   +2 more
doaj   +1 more source

Murine tissue factor coagulant activity is critically dependent on the presence of an intact allosteric disulfide

Haematologica, 2013
Tissue factor activation (decryption) has been proposed to be dependent on the cysteine 186-cysteine 209 allosteric disulfide in the tissue factor extracellular domain.
Lisa G. van den Hengel, Susanne Osanto, Pieter H. Reitsma, Henri H. Versteeg   +3 more
doaj   +1 more source

Oxidative protein biogenesis and redox regulation in the mitochondrial intermembrane space [PDF]

, 2016
Mitochondria are organelles that play a central role in cellular metabolism, as they are responsible for processes such as iron/sulfur cluster biogenesis, respiration and apoptosis.
MacPherson, Lisa, Manganas, Phanee, Tokatlidis, Kostas   +2 more
core   +1 more source

Protein disulfide isomerase interacts with tau protein and inhibits its fibrillization. [PDF]

PLoS ONE, 2013
BACKGROUND: Tau protein is implicated in the pathogenesis of neurodegenerative disorders such as tauopathies including Alzheimer disease, and Tau fibrillization is thought to be related to neuronal toxicity. Physiological inhibitors of Tau fibrillization
Li-Rong Xu, Xiao-Ling Liu, Jie Chen, Yi Liang   +3 more
doaj   +1 more source

Recognition and ER Quality Control of Misfolded Formylglycine-Generating Enzyme by Protein Disulfide Isomerase

Cell Reports, 2018
Summary: Multiple sulfatase deficiency (MSD) is a fatal, inherited lysosomal storage disorder characterized by reduced activities of all sulfatases in patients.
Lars Schlotawa, Michaela Wachs, Olaf Bernhard, Franz J. Mayer, Thomas Dierks, Bernhard Schmidt, Karthikeyan Radhakrishnan   +6 more
doaj   +1 more source

Protein disulfide isomerase family member 4 promotes triple-negative breast cancer tumorigenesis and radiotherapy resistance through JNK pathway [PDF]

Breast Cancer Res
Jinqiu Tao, Cailin Xue, Meng Cao, Jiahui Ye, Yulu Sun, Hao Chen, Yinan Guan, Wenjie Zhang, Weijie Zhang, Yongzhong Yao   +9 more
openalex   +2 more sources