Results 181 to 190 of about 7,315 (215)

Promotion of insulin aggregation by protein disulfide isomerase

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2007
We examined the aggregation of insulin as a result of reduction of disulfide bonds catalyzed by protein disulfide isomerase (PDI) using various techniques. We demonstrated the kinetic correlation between PDI-catalyzed insulin reduction and the aggregate formation, the relationship between aggregation and amyloid formation, and the structural ...
Ryosuke, Maeda, Kazuyoshi, Ado, Naohiro, Takeda, Yoshihiro, Taniguchi   +3 more
openaire   +2 more sources

Coagulation factor XIII serves as protein disulfide isomerase

Thrombosis and Haemostasis, 2009
SummaryTissue transglutaminase was reported to act as protein disulfide isomerase (PDI). We studied whether plasma transglutaminase – coagulation factor XIII (FXIII) – has PDI activity as well. PDI activity was measured by determining the ability to renature reduced-denatured RNase (rdRNase).
Judith, Lahav, Eli, Karniel, Zsuzsa, Bagoly, Vera, Sheptovitsky, Rima, Dardik, Aida, Inbal   +5 more
openaire   +2 more sources

Protein disulfide isomerase mediates glutathione depletion-induced cytotoxicity

Biochemical and Biophysical Research Communications, 2016
Glutathione depletion is a distinct cause underlying many forms of pathogenesis associated with oxidative stress and cytotoxicity. Earlier studies showed that glutamate-induced glutathione depletion in immortalized murine HT22 hippocampal neuronal cells leads to accumulation of reactive oxygen species (ROS) and ultimately cell death, but the precise ...
Kazushi, Okada, Masayuki, Fukui, Bao-Ting, Zhu   +2 more
openaire   +2 more sources

ER calcistorin/protein disulfide isomerase

1996
Abstract ER calcistorin!Protein disulfide isomerase (ECaSt!POJ), identified in the endoplasmic reticulum (ER) of the sea urchin egg, is a high capacity, low affinity Ca2+-binding protein which also has POI activity. The molecule apparently has a dual function of Ca2+storage and POI activity in the ER of the sea urchin egg.
openaire   +1 more source

Protein Disulfide Isomerase

2016
Andrea Shergalis, Nouri Neamati
openaire   +1 more source

Mechanisms, regulation and functions of the unfolded protein response

Nature Reviews Molecular Cell Biology, 2020
Claudio Hetz, Kezhong Zhang, Randal J Kaufman   +2 more
exaly  

Protein disulfide-isomerase.

Methods in enzymology, 1995
R B, Freedman, H C, Hawkins, S H, McLaughlin   +2 more
openaire   +1 more source

Biomolecular condensates at the nexus of cellular stress, protein aggregation disease and ageing

Nature Reviews Molecular Cell Biology, 2021
Simon Alberti, Anthony A Hyman
exaly  

[38] Protein disulfide-isomerase

1995
Robert B. Freedman, Hilary C. Hawkins, Stephen H. McLaughlin   +2 more
openaire   +1 more source

The mechanisms of integral membrane protein biogenesis

Nature Reviews Molecular Cell Biology, 2021
Ramanujan Shankar Hegde, Robert J Keenan
exaly