Results 41 to 50 of about 6,745 (114)

Oxidative protein biogenesis and redox regulation in the mitochondrial intermembrane space [PDF]

, 2016
Mitochondria are organelles that play a central role in cellular metabolism, as they are responsible for processes such as iron/sulfur cluster biogenesis, respiration and apoptosis.
MacPherson, Lisa, Manganas, Phanee, Tokatlidis, Kostas   +2 more
core   +1 more source

A cellular model of TDP‐43 induces phosphorylated TDP‐43 aggregation with distinct changes in solubility and autophagy dysregulation

The FEBS Journal, EarlyView.
TDP‐43 protein plays a pathological role in sporadic and familial amyotrophic lateral sclerosis (ALS). Here, we developed a cellular model overexpressing TDP‐43 with three mutations linked to familial ALS, termed ‘3X‐TDP‐43’. Mutant 3X‐TDP‐43 expression showed deficits in autophagy flux and colocalization with stress granules.
Matthew B. Dopler, Muhammad I. Abeer, Sanaz Arezoumandan, Keyshawn Cox, Tyler L. Petersen, Esther H. Daniel, Carlton L. Cannon III, Angelica Bautista, Kennedy D. Blancher, Alysia M. Bland, Kylie J. Bond, Dominque A. Davis, Jessica M. Francois, Eliana J. McCray, Justin M. Morgan, Jessica L. Pulliam, Zymir A. Robinson, Mykia J. Taylor, James A. Dowell, Nigel J. Cairns, Michael A. Gitcho   +20 more
wiley   +1 more source

Epidermal proteomics demonstrates Elafin as a psoriasis‐specific biomarker and highlights increased anti‐inflammatory activity around psoriatic plaques

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Epidermal sampling of lesional, perilesional and non‐lesional skin from psoriasis and eczema patients as well as healthy skin was used to perform an in depth proteomic analysis. IL‐36γ known to be expressed in lesional psoriasis skin was outperformed by the protease inhibitor Elafin as a disease‐specific epidermal biomarker.
Anna Berekmeri, Tom Macleod, Isabel Hyde, Gregor Jan Ojak, Caroline Mann, Daniela Kramer, Martin Stacey, Miriam Wittmann   +7 more
wiley   +1 more source

Oxidative protein folding in bacteria [PDF]

, 2002
Ten years ago it was thought that disulphide bond formation in prokaryotes occurred spontaneously. Now two pathways involved in disulphide bond formation have been well characterized, the oxidative pathway, which is responsible for the formation of ...
Andersen, Bader, Bader, Bader, Bader, Bardwell, Bardwell, Bessette, Chen, Chung, Couprie, Crooke, Dailey, Deshmukh, Fong, Gordon, Grauschopf, Guddat, Guddat, Guilhot, Jacob-Dubuisson, James C. A. Bardwell, Jean-Francois Collet, Kadokura, Kamitani, Katzen, Kishigami, Kishigami, Kobayashi, Kobayashi, Kobayashi, Krupp, Martin, McCarthy, Metheringham, Missiakas, Missiakas, Missiakas, Pugsley, Raina, Rietsch, Rietsch, Sauvonnet, Shao, Stafford, Stewart, Sun, Zapun, Zapun, Zheng   +49 more
core   +1 more source

Salivary Proteomics for Detecting Novel Biomarkers of Periodontitis: A Systematic Review

Journal of Periodontal Research, EarlyView.
Untargeted salivary proteomics identified promising biological molecules consistently over‐ or under‐expressed in periodontitis patients compared to periodontally healthy subjects, but further targeted approaches are required for their validation. ABSTRACT Aim Salivary content is regarded as a powerful diagnostic window for oral and systemic diseases ...
Matteo Corana, Giacomo Baima, Giovanni Iaderosa, Francesco Franco, Jianjian Zhang, Giovanni Nicolao Berta, Federica Romano, Mario Aimetti   +7 more
wiley   +1 more source

Matching maternal and paternal experiences underpin molecular thermal acclimation

Molecular Ecology, EarlyView.
Abstract The environment experienced by one generation has the potential to affect the subsequent one through non‐genetic inheritance of parental effects. Since both mothers and fathers can influence their offspring, questions arise regarding how the maternal, paternal and offspring experiences integrate into the resulting phenotype.
L. C. Bonzi, J. M. Donelson, R. K. Spinks, P. L. Munday, T. Ravasi, C. Schunter   +5 more
wiley   +1 more source

Two-dimensional gel electrophoresis in proteomics: A tutorial [PDF]

, 2011
Two-dimensional electrophoresis of proteins has preceded, and accompanied, the birth of proteomics. Although it is no longer the only experimental scheme used in modern proteomics, it still has distinct features and advantages.
##Righetti, ##Righetti, ##Westermeier, #Celis, Afjehi-Sadat, Aicher, Anderson, Appel, Bravo, Bredemeyer, Burre, Cejka, Celis, Chevalier, Chevallet, Chevallet, Chevallet, Corbett, Cécile Lelong, Damerval, Eravci, Garrels, Ghaemmaghami, Gianazza, Gordon, Gorg, Gorg, Gravel, Gronow, Hackett, Harder, Hartinger, Ingolia, Ishigami, Ivanov, John, Karp, Klose, Kondo, Laemmli, Lelong, Lelong, Lovato, Lu, Luche, Luche, Maltese, Mechin, Nakamura, Olsson, Orrick, Perdew, Perluigi, Perrot, Pitarch, Pun, Rabilloud, Rabilloud, Rabilloud, Rabilloud, Rasmussen, Richert, Righetti, Sanchez-Campillo, Semple-Rowland, Seo, Sinha, Sobel, Tannu, Tarroux, Tarroux, Taylor, Thierry Rabilloud, Tuszynski, Viswanathan, Wen, Wildgruber, Wildgruber, Yang, Zhan, Zhou, ⁎Gorg, ⁎Gorg, ⁎Hecker, ⁎Miller, ⁎Miller, ⁎Minden, ⁎Patton, ⁎Petrak, ⁎Rabilloud, ⁎Rabilloud, ⁎Rabilloud, ⁎Righetti, ⁎Wang, ⁎Westermeier, ⁎⁎Aebersold, ⁎⁎Anderson, ⁎⁎Anderson, ⁎⁎Bravo, ⁎⁎Gorg, ⁎⁎James, ⁎⁎MacGillivray, ⁎⁎Matsudaira, ⁎⁎Neuhoff, ⁎⁎O'Farrell, ⁎⁎Rabilloud, ⁎⁎Rosenfeld, ⁎⁎Unlu, ⁎⁎Wilkins   +108 more
core   +3 more sources

Alternative Splicing Regulation in Metabolic Disorders

Obesity Reviews, EarlyView.
ABSTRACT Alternative splicing (AS) is a fundamental mechanism for enhancing transcriptome diversity and regulating gene expression, crucial for various cellular processes and the development of complex traits. This review examines the role of AS in metabolic disorders, including obesity, weight loss, dyslipidemias, and metabolic syndrome.
Dorota Kaminska
wiley   +1 more source

Artificial disulfide isomerases and uses thereof [PDF]

, 2007
The present invention provides artificial enzymes comprising, e.g., an N-terminal domain derived from E. coli FkpA that allows for dimerization and provides a substrate binding region, and a C-terminal thioredoxin domain derived from E.
George M. Georgiou, Laura Segatori
core   +1 more source

Molecular changes in agroinfiltrated leaves of Nicotiana benthamiana expressing suppressor of silencing P19 and coronavirus‐like particles

Plant Biotechnology Journal, EarlyView.
Summary The production of coronavirus disease 2019 vaccines can be achieved by transient expression of the spike (S) protein of severe acute respiratory syndrome coronavirus 2 in agroinfiltrated leaves of Nicotiana benthamiana. Relying on bacterial vector Agrobacterium tumefaciens, this process is favoured by co‐expression of viral silencing suppressor
Louis‐Philippe Hamel, Francis Poirier‐Gravel, Marie‐Ève Paré, Rachel Tardif, Marc‐André Comeau, Pierre‐Olivier Lavoie, Andréane Langlois, Marie‐Claire Goulet, Dominique Michaud, Marc‐André D'Aoust   +9 more
wiley   +1 more source