Results 41 to 50 of about 3,285 (194)

Reticulon1-C modulates protein disulphide isomerase function [PDF]

, 2013
Endoplasmic reticulum (ER) is the primary site for the synthesis and folding of secreted and membrane-bound proteins. Accumulation of unfolded and misfolded proteins in ER underlies a wide range of human neurodegenerative disorders.
Bernardoni, P, Ciriolo, M, Costanzi, A, Di Sano, F, Fazi, B, Filomeni, G, Montagna, C, Nardacci, R, Piacentini, M   +8 more
core   +1 more source

Thiol Isomerases: Enzymatic Mechanisms, Models of Oxidation, and Antagonism by Galloylated Polyphenols

Antioxidants
Thiol isomerases are a family of enzymes that participate in oxidative protein folding. They contain highly reactive vicinal thiols in a CXXC motif within their catalytic domains to mediate thiol-disulfide switching as part of their reductase, oxidase ...
Osamede C. Owegie, Quinn P. Kennedy, Pavel Davizon-Castillo, Moua Yang   +3 more
doaj   +1 more source

Proteins, Processing, and Properties of Adhesive Fluid Condensates Purified from Mussels

Advanced Functional Materials, EarlyView.
Mussels exhibit an unmatched proficiency for adhering to wet surfaces in salty environments—a remarkable ability that could inspire new biomedical and technical glues. The fluid protein condensates used to form the underwater mussel glue are extracted, reconstituted and characterized with advanced spectroscopy and nanomechanical analysis, revealing ...
Mathieu D. Rivard, Max Renner‐Rao, Nahid Hassanpour, Franziska Jehle, Chang‐Sheng Wang, Duy Anh Pham, Daniel J. Jackson, Xavier Banquy, Matthew J. Harrington   +8 more
wiley   +1 more source

Recent advances in vascular thiol isomerases: insights into structures, functions in thrombosis and antithrombotic inhibitor development

Thrombosis Journal
Vascular thiol isomerases (VTIs) encompass proteins such as protein disulfide isomerase (PDI), endoplasmic reticulum protein 5 (ERp5), ERp46, ERp57, ERp72, thioredoxin-related transmembrane protein 1 (TMX1), and TMX4, and play pivotal functions in ...
Longguang Jiang, Cai Yuan, Robert Flaumenhaft, Mingdong Huang   +3 more
doaj   +1 more source

Non-Canonical, Strongly Selective Protein Disulfide Isomerases as Anticancer Therapeutic Targets

Biomolecules
Protein Disulfide Isomerases (PDIs) are emerging targets in anticancer therapy, with several PDI inhibitors demonstrating anticancer efficacy in preclinical models.
Mary E. Law, Zaafir M. Dulloo, Brian Hardy, Ania Kelegama, Reagan Clark, Mariana Rivas Montbrun, Gabriella Antmann, Srihith Nooka, Ronald K. Castellano, Brian K. Law   +9 more
doaj   +1 more source

Importance of disulphide bonds for vaccinia virus L1R protein function

Virology Journal, 2005
L1R, a myristylated late gene product of vaccinia virus, is essential for formation of infectious intracellular mature virions (IMV). In its absence, only viral particles arrested at an immature stage are detected and no infectious progeny virus is ...
Hruby Dennis E, Byrd Chelsea M, Blouch Robert E   +2 more
doaj   +1 more source

Disulfide isomerase ERp57 improves the stability and immunogenicity of H3N2 influenza virus hemagglutinin

Virology Journal, 2020
Background Hemagglutinin (HA), as the surface immunogenic protein, is the most important component of influenza viruses. Previous studies showed that the stability of HA was significant for HA’s immunogenicity, and many efforts have been made to ...
Jialing Wu, Yang Wang, Ying Wei, Zhichao Xu, Xin Tan, Zhihui Wu, Jing Zheng, George Dacai Liu, Yongchang Cao, Chunyi Xue   +9 more
doaj   +1 more source

A point mutation in the Pdia6 gene results in loss of pancreatic β-cell identity causing overt diabetes

Molecular Metabolism, 2021
Objective: Protein disulfide isomerases (PDIs) are oxidoreductases that are involved in catalyzing the formation and rearrangement of disulfide bonds during protein folding.
Nirav Florian Chhabra, Anna–Lena Amend, Aimée Bastidas-Ponce, Sibylle Sabrautzki, Marta Tarquis-Medina, Stephan Sachs, Marina Rubey, Bettina Lorenz-Depiereux, Annette Feuchtinger, Mostafa Bakhti, Heiko Lickert, Gerhard K.H. Przemeck, Martin Hrabě de Angelis   +12 more
doaj   +1 more source

Structural and functional characterization of the oxidoreductase a-DsbA1 from wolbachia pipientis

, 2009
The α-proteobacterium Wolbachia pipientis is a highly successful intracellular endosymbiont of invertebrates that manipulates its host\u27s reproductive biology to facilitate its own maternal transmission. The fastidious nature of Wolbachia and the
Frei, Patrick, Glockshuber, Rudi, Heras, Begoña, Iturbe-Ormaetxe, Iñaki, Jarrott, Russell, Kurz, Mareike, Martin, Jennifer L., O’Neill, Scott L., Shouldice, Stephen R., Wouters, Merridee A.   +9 more
core   +1 more source

Oxidative protein biogenesis and redox regulation in the mitochondrial intermembrane space [PDF]

, 2016
Mitochondria are organelles that play a central role in cellular metabolism, as they are responsible for processes such as iron/sulfur cluster biogenesis, respiration and apoptosis.
MacPherson, Lisa, Manganas, Phanee, Tokatlidis, Kostas   +2 more
core   +1 more source