Results 51 to 60 of about 7,369 (220)

ERdj5 is the ER reductase that catalyzes the removal of non-native disulfides and correct folding of the LDL receptor [PDF]

, 2013
ERdj5 is a member of the protein disulfide isomerase family of proteins localized to the endoplasmic reticulum (ER) of mammalian cells. To date, only a limited number of substrates for ERdj5 are known.
Braakman, Ineke, Bulleid, Neil John, Oka, Ojore Benedict Valentine, Pringle, Marie Anne, Schopp, Isabel Myriam   +4 more
core   +1 more source

Myricetin, the Main Flavonoid in Syzygium cumini Leaf, Is a Novel Inhibitor of Platelet Thiol Isomerases PDI and ERp5

Frontiers in Pharmacology, 2020
BackgroundFlavonoids have been characterized as a prominent class of compounds to treat thrombotic diseases through the inhibition of thiol isomerases. Syzygium cumini is a flavonoid-rich medicinal plant that contains myricetin and gallic acid. Little is
Renato Simões Gaspar, Renato Simões Gaspar, Samira Abdalla da Silva, Jennifer Stapleton, João Lucas de Lima Fontelles, Hiran Reis Sousa, Vinicyus Teles Chagas, Shuruq Alsufyani, Andrés Trostchansky, Jonathan M. Gibbins, Antonio Marcus de Andrade Paes   +10 more
doaj   +1 more source

Molecular characterization and expression profiling of the protein disulfide isomerase gene family in Brachypodium distachyon L. [PDF]

PLoS ONE, 2014
Protein disulfide isomerases (PDI) are involved in catalyzing protein disulfide bonding and isomerization in the endoplasmic reticulum and functions as a chaperone to inhibit the aggregation of misfolded proteins. Brachypodium distachyon is a widely used
Chong Zhu, Nana Luo, Miao He, Guanxing Chen, Jiantang Zhu, Guangjun Yin, Xiaohui Li, Yingkao Hu, Jiarui Li, Yueming Yan   +9 more
doaj   +1 more source

Anterior gradient protein 2 promotes survival, migration and invasion of papillary thyroid carcinoma cells [PDF]

, 2014
Through a transcriptome microarray analysis, we have isolated Anterior gradient protein 2 (AGR2) as a gene up-regulated in papillary thyroid carcinoma (PTC).
Chiappetta, G, Di Maro, G, Jarzab, B, Masullo, M, Monaco, M, Oczko-Wojciechowska, M, Orlandella, FM, Salerno, P, Salvatore, G, Santoro, M, Thomas, G, Unger, K   +11 more
core   +1 more source

AS‐pHopt: An Optimal pH Prediction Model Enhanced by Active Site of Enzymes

Advanced Intelligent Discovery, EarlyView.
To address the low accuracy of enzyme optimal pH (pHopt) prediction, this study develops active site‐based pHopt (AS‐pHopt), a prediction model enhanced by active site information and pseudo‐label prediction. Integrating key structural and physicochemical features affecting enzyme pHopt, AS‐pHopt uses Evolutionary Scale Modeling (ESM)‐2 with active ...
Wenxiang Song, Xinmin Li, Hongbo Yu, Le Xiong, Guixia Liu, Weihua Li, Yun Tang   +6 more
wiley   +1 more source

Oxidative protein biogenesis and redox regulation in the mitochondrial intermembrane space [PDF]

, 2016
Mitochondria are organelles that play a central role in cellular metabolism, as they are responsible for processes such as iron/sulfur cluster biogenesis, respiration and apoptosis.
MacPherson, Lisa, Manganas, Phanee, Tokatlidis, Kostas   +2 more
core   +1 more source

Structural and Biological Insights Into Copper(I) Phosphane Complexes With Boron‐Phenylated Poly(3‐(CF3)Pyrazolyl)‐ and Poly(6‐(CF3)‐2‐pyridyl)‐Borates

Chemistry – A European Journal, EarlyView.
This study reports six new copper(I) complexes with unusual coordination and strong anticancer activity against a panel of human cancer cell lines derived from different solid tumors. The most active compounds outperform cisplatin, even in resistant cells, by inhibiting protein disulfide isomerase and inducing redox stress that triggers non‐apoptotic ...
Vo Quang Huy Phan, Jo’ Del Gobbo, Mukundam Vanga, Deepika V. Karade, Cristina Marzano, Valentina Gandin, Laura Rigon, Carlo Santini, Maura Pellei, H. V. Rasika Dias   +9 more
wiley   +1 more source

Importance of disulphide bonds for vaccinia virus L1R protein function

Virology Journal, 2005
L1R, a myristylated late gene product of vaccinia virus, is essential for formation of infectious intracellular mature virions (IMV). In its absence, only viral particles arrested at an immature stage are detected and no infectious progeny virus is ...
Hruby Dennis E, Byrd Chelsea M, Blouch Robert E   +2 more
doaj   +1 more source

Structural and functional characterization of the oxidoreductase a-DsbA1 from wolbachia pipientis

, 2009
The α-proteobacterium Wolbachia pipientis is a highly successful intracellular endosymbiont of invertebrates that manipulates its host\u27s reproductive biology to facilitate its own maternal transmission. The fastidious nature of Wolbachia and the
Frei, Patrick, Glockshuber, Rudi, Heras, Begoña, Iturbe-Ormaetxe, Iñaki, Jarrott, Russell, Kurz, Mareike, Martin, Jennifer L., O’Neill, Scott L., Shouldice, Stephen R., Wouters, Merridee A.   +9 more
core   +1 more source

Secretopathies emerge as a new class of neurocristopathies

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are a transient embryonic population of cells that give rise to a wide range of structures, including craniofacial cartilage and bone, peripheral neurons and glia, as well as components of the cardiac outflow tract, among others.
Amanda Teixeira, Cassandra Millet‐Boureima, Joshua A. Moore, Loydie A. Jerome‐Majewska   +3 more
wiley   +1 more source