Results 71 to 80 of about 3,392,726 (209)

Bioactive Natural Products in Cardiovascular Disease: Focus on Thrombotic Events

Phytotherapy Research, EarlyView.
An overview of the role of natural products (NP) in cardiovascular disease prevention, highlighting key mechanisms of action: including antiplatelet, antithrombotic, anti‐inflammatory, and antioxidant effects. Additionally, it illustrates the integration of diet–drug interactions, nutritional epigenetics, and the role of artificial intelligence in ...
Maria Nektaria Magkoulia, Despoina Pantazi   +1 more
wiley   +1 more source

Interactome analyses identify ties of PrP and its mammalian paralogs to oligomannosidic N-glycans and endoplasmic reticulum-derived chaperones. [PDF]

PLoS Pathogens, 2009
The physiological environment which hosts the conformational conversion of the cellular prion protein (PrP(C)) to disease-associated isoforms has remained enigmatic.
Joel C Watts, Hairu Huo, Yu Bai, Sepehr Ehsani, Amy Hye Won Jeon, Tujin Shi, Nathalie Daude, Agnes Lau, Rebecca Young, Lei Xu, George A Carlson, David Williams, David Westaway, Gerold Schmitt-Ulms   +13 more
doaj   +1 more source

Protein Disulfide Isomerase and Host-Pathogen Interaction [PDF]

The Scientific World JOURNAL, 2011
Reactive oxygen species (ROS) production by immunological cells is known to cause damage to pathogens. Increasing evidence accumulated in the last decade has shown, however, that ROS (and redox signals) functionally regulate different cellular pathways in the host-pathogen interaction.
Stolf, Beatriz S., Smyrnias, Ioannis, Lopes, Lucia R., Vendramin, Alcione, Goto, Hiro, Laurindo, Francisco R. M., Shah, Ajay M., Santos, Celio X. C.   +7 more
openaire   +3 more sources

Antibody Conjugates via Disulfide Bridging: Towards therapeutic and diagnostic applications [PDF]

, 2015
Antibodies play a prominent role in chemical and biological research and the largest application of chemical bioconjugation reagents is in the production of antibody conjugates.
Hull, EA
core  

Structure of recombinant Thermoascus aurantiacus xylanase TaXyn10 with an authentic N‐terminal pyroglutamate

Acta Crystallographica Section F, EarlyView.
The high‐resolution structure of the T. aurantiacus xylanase TaXyn10 expressed in Escherichia coli shows that recombinant production combined with split‐intein‐based purification recovers the native fold of TaXyn10 and permits the formation of an N‐terminal pyroglutamate.
Jelena Mijatovic, Uwe Mueller, Manfred S. Weiss, Frank Lennartz   +3 more
wiley   +1 more source

Targeting protein–protein interactions with reversible covalent modalities: Non‐cysteine chemistries

British Journal of Pharmacology, EarlyView.
Abstract Protein–protein interactions (PPIs) are central to diverse cellular functions, and represent a rapidly expanding class of therapeutic targets. Advancements in covalent drug design have enabled small‐molecule drugs to overcome challenges associated with engaging these targets, such as limited durations of action and difficult‐to‐drug (expansive,
Ruchira Basu, Steven Fletcher
wiley   +1 more source

Cell-type specific requirements for thiol/disulfide exchange during HIV-1 entry and infection

Retrovirology, 2012
Background The role of disulfide bond remodeling in HIV-1 infection is well described, but the process still remains incompletely characterized. At present, the data have been predominantly obtained using established cell lines and/or CXCR4-tropic ...
Stantchev Tzanko S, Paciga Mark, Lankford Carla R, Schwartzkopff Franziska, Broder Christopher C, Clouse Kathleen A   +5 more
doaj   +1 more source

Mapping of the ligand-binding site on the b ' domain of human PDI: interaction with peptide ligands and the x-linker region [PDF]

, 2009
PDI (protein disulfide-isomerase) catalyses the formation of native disulfide bonds of secretory proteins in the endoplasmic reticulum. PDI consists of four thioredoxin-like domains, of which two contain redox-active catalytic sites (a and a'), and two ...
Freedman, R. B., Howard, M., Williamson, Richard A., Howard, Mark J., Wallis, A. Katrine, Ruddock, Lloyd W., Sidhu, A., Wallis, A., Williamson, R., Byrne, Lee J., Freedman, Robert B., Ruddock, L., Sidhu, Ateesh, Wallis, Anne Katrine, Byrne, L., Freedman, R.   +15 more
core   +1 more source

Reactive oxygen species, antioxidants and the regulation of plant development

The FEBS Journal, EarlyView.
The regulation of axillary bud outgrowth by the interplay between phytohormone and redox signals. Axillary bud outgrowth is regulated by cellular energy status and the balance between phytohormones, notably abscisic acid (ABA) and gibberellic acid (GA).
Juwita R. Dewi, Christine H. Foyer, Michael J. Considine   +2 more
wiley   +1 more source

The dehydrogenase region of the NADPH oxidase component Nox2 acts as a protein disulfide isomerase (PDI) resembling PDIA3 with a role in the binding of the activator protein p67phox

Frontiers in Chemistry, 2015
The superoxide (O2.-)-generating NADPH oxidase of phagocytes consists of a membrane component, cytochrome b558 (a heterodimer of Nox2 and p22phox), and four cytosolic components, p47phox, p67phox, p40phox, and Rac.
Edna eBechor, Iris eDahan, Tanya eFradin, Yevgeny eBerdichevsky, Anat eZahavi, Meirav eRafalowski, Aya eFederman-Gross, Edgar ePick   +7 more
doaj   +1 more source