Results 81 to 90 of about 3,392,726 (209)

The Role of Oxidative Stress in Periodontitis

Journal of Periodontal Research, EarlyView.
Oxidative stress is involved in multiple chemical reactions that take place in different intracellular organelles: mitochondria, rough endoplasmic reticulum, peroxisomes, autophagy, and aging, and can be influenced by exogenous factors: nutrition, physical activity, psychological status, environmental conditions, microbiome, and drugs.
Pedro Bullon, Francesca Giampieri, Beatriz Bullon, Maurizio Battino   +3 more
wiley   +1 more source

Protein disulfide isomerase MoPdi1 regulates fungal development, virulence, and endoplasmic reticulum homeostasis in Magnaporthe oryzae

Journal of Integrative Agriculture
Rice blast, caused by Magnaporthe oryzae, is a fungal disease that causes devastating damage to rice production worldwide. During infection, pathogens secrete effector proteins that modulate plant immunity.
Yu Wang, Xiaoru Kang, Xinyue Cui, Jinmei Hu, Yuemin Pan, Yizhen Deng, Shulin Zhang   +6 more
doaj   +1 more source

Stability and Conformational Resilience of Protein Disulfide Isomerase

Biochemistry, 2019
Protein disulfide isomerase (PDI) is a redox-dependent protein with oxidoreductase and chaperone activities. It is a U-shaped protein with an abb'xa' structural organization in which the a and a' domains have CGHC active sites, the b and b' domains are involved with substrate binding, and x is a flexible linker. PDI exhibits substantial flexibility and
Jessica Guyette, Baggio Evangelista, Suren A. Tatulian, Ken Teter   +3 more
openaire   +3 more sources

Staphylococcal extracellular adherence protein induces platelet activation by stimulation of thiol isomerases

, 2012
OBJECTIVE: Staphylococcus aureus can induce platelet aggregation. The rapidity and degree of this correlates with the severity of disseminated intravascular coagulation, and depends on platelet peptidoglycans.
Peters, Georg, Judith Lahav, Müller, Anja, Tina Schifferdecker, Joachim Roth, Kerstin Jurk, Bertling, Anne, Stanley, Ronald G., Anne Bertling, Muzaffar Hussain, Pohl, Silke, Roth, Joachim, Beate E. Kehrel, Schifferdecker, Tina, Ronald G. Stanley, Lahav, Judith, Anja Müller, Kehrel, Beate E., Lisa Holbrook, Jonathan M. Gibbins, Niemann, Silke, Jurk, Kerstin, Hussain, Muzaffar, Hussain, Muzaffar S., Silke Niemann, Silke Pohl, Brodde, Martin F., Gibbins, Jonathan M., Christine Heilmann, Martin F. Brodde, Georg Peters, Holbrook, Lisa, Heilmann, Christine   +32 more
core   +1 more source

Decoding PDI diversity: Insights into structure, domains, and functionality in sorghum

Computational and Structural Biotechnology Journal
Proteins play indispensable roles in cellular function, acting as both structural components and catalysts for essential biological processes. Their proper folding into three-dimensional structures is critical for functionality. To ensure correct folding,
Carla F. López-Gómez, Marc T. Morris, Karen Massel, Millicent Smith, Peter Crisp, Gerhard Schenk, Ian D. Godwin   +6 more
doaj   +1 more source

Process Intensification for an Insect Antimicrobial Peptide Elastin-Like Polypeptide Fusion Produced in Redox-Engineered Escherichia coli

Frontiers in Bioengineering and Biotechnology, 2019
Peptides and proteins containing disulfide bonds can be produced in Escherichia coli by targeting the oxidizing periplasm, co-expressing isomerases or chaperons, refolding from inclusion bodies, or by using redox-engineered E. coli strains.
Mathias Joachim, Mathias Joachim, Nicolas Maguire, Johannes Schäfer, Doreen Gerlach, Peter Czermak, Peter Czermak, Peter Czermak   +7 more
doaj   +1 more source

Compact Conformations of Human Protein Disulfide Isomerase

PLoS ONE, 2014
Protein disulfide isomerase (PDI) composed of four thioredoxin-like domains a, b, b', and a', is a key enzyme catalyzing oxidative protein folding in the endoplasmic reticulum. Large scale molecular dynamics simulations starting from the crystal structures of human PDI (hPDI) in the oxidized and reduced states were performed.
Shang Yang, Xi Wang, Lei Cui, Xiang Ding, Lili Niu, Fuquan Yang, Chao Wang, Chih-Chen Wang, Jizhong Lou   +8 more
openaire   +4 more sources

Transcriptomic and proteomic signatures underlying nymphal adaptation and foam production in the forage pest Mahanarva spectabilis

Insect Molecular Biology, Volume 35, Issue 5, Page 556-575, October 2026.
RNA‐seq and Batelli gland proteomics of fifth‐instar Mahanarva spectabilis nymphs reveal transcripts and proteins associated with xylem feeding, foam production and environmental interaction. Functional annotation identified genes involved in osmoregulation, detoxification, chemosensation and stress responses, while proteomic analysis confirmed ...
Monique da Silva Bonjour, Angelo José Rinaldi, Eulálio Gutemberg Dias dos Santos, Gabriely Teixeira Bhering Faria, Ana Márcia Escocard de Azevedo Manhães, Jorge Fernando Pereira, Alexander Machado Auad, Maria Goreti de Almeida Oliveira, Humberto Josué de Oliveira Ramos   +8 more
wiley   +1 more source

Relaxin‐2: Shaping the Proteomic Landscape of Skeletal Muscle Physiology, Glucose Trafficking, and Mitochondrial Function in Rat

The FASEB Journal, Volume 40, Issue 18, 30 September 2026.
Cardioprotective hormone relaxin‐2 showed relevant effects on rat skeletal muscle by altering proteins linked to muscle function, regeneration, differentiation, mitochondrial function, glucose metabolism, and structural integrity and organization. Specifically, relaxin‐2 reduced the expression of 95 proteins, increased 32, and elicited unique proteins ...
Xocas Vázquez‐Abuín, Lucía Gómez‐Cibeira, Javier García‐Seara, Pablo de la Fuente‐López, Carlos Minguito‐Carazo, Susana B. Bravo, Manuel Otero‐Santiago, Oreste Gualillo, José Ramón González‐Juanatey, Francisca Lago, Sandra Feijóo‐Bandín, Alana Aragón‐Herrera   +11 more
wiley   +1 more source

Quantitative interactome mapping of skeletal muscle insulin resistance

Molecular Systems Biology
Protein-protein interactions (PPIs) are dynamic and critical to adaptive homeostasis. While there have been massive efforts to catalogue proteome-wide PPIs, global quantification of changes remains a challenge.
Yaan-Kit Ng, Ronnie Blazev, Julian P H Wong, Nichollas E Scott, Jeffrey Molendijk, Benjamin L Parker   +5 more
doaj   +1 more source