Results 101 to 110 of about 3,392,726 (209)

Emerging roles of protein disulfide isomerase in cancer

BMB Reports, 2017
The protein disulfide isomerase (PDI) family is a group of multifunctional endoplasmic reticulum (ER) enzymes that mediate the formation of disulfide bonds, catalyze the cysteine-based redox reactions and assist the quality control of client proteins. Recent structural and functional studies have demonstrated that PDI members not only play an essential
Lee, Eunyoug, Lee, Do Hee
openaire   +3 more sources

Oxidative and Antioxidant Systems in Ferroptosis of Cancer: Mechanisms, Regulations, and Therapeutic Targeting

MedComm – Oncology, Volume 5, Issue 3, September 2026.
Ferroptosis is governed by the balance between reactive oxygen species (ROS)‐driven lipid peroxidation and a multi‐tiered antioxidant network. ROS sources include mitochondrial electron transport chain, voltage‐dependent anion channels, NADPH oxidases, and endoplasmic reticulum‐resident oxidoreductases, while antioxidant defenses span the primary GSH ...
Deepak K, Pritam Kumar Roy, Maniklal Shee, Budhaditya Mukherjee, Aoife Ward Gahlawat, Mahitosh Mandal   +5 more
wiley   +1 more source

Protein Disulfide Isomerases Function as the Missing Link Between Diabetes and Cancer. [PDF]

Antioxid Redox Signal, 2022
Jiang H, Thapa P, Hao Y, Ding N, Alshahrani A, Wei Q.   +5 more
europepmc   +1 more source

The multidrug resistance IncA/C transferable plasmid encodes a novel domain swapped dimeric protein disulfide isomerase [PDF]

, 2013
Background: Bacterial IncA/C plasmids distribute antibiotic resistance genes and encode a conserved thioredoxin-fold protein (DsbP). Results: DsbP shuffles incorrect disulfide bonds in misfolded proteins, and its structure diverges from previously ...
Neyer, Simon, Schembri, Mark A., Martin, Jennifer L, Martin, Jennifer L., Premkumar, Lakshmanane, Premkumar, L., Schembri, Mark A, Kurth, Fabian   +7 more
core   +1 more source

Confirmation of the Disulfide Connectivity and Strategies for Chemical Synthesis of the Four-Disulfide-Bond-Stabilized Aspergillus giganteus Antifungal Protein, AFP

, 2023
Emerging fungal infections require new, more efficient antifungal agents and therapies. AFP, a protein from Aspergillus giganteus with four disulfide bonds, is a promising candidate because it selectively inhibits the growth of filamentous fungi. In this
Dorottya Hajdu (3628850), Sascha Jung (556123), Gyula Batta (188166), Györgyi Váradi (1652827), László Galgóczy (14683884), Vera Meyer (436900), Zoltán Kele (1502758), Florentine Marx (3459467), Máté Virágh (14683890), Gábor K. Tóth (1652833), Ádám Fizil (14683887), András Czajlik (1648093)   +11 more
core   +1 more source

Production of the High Value Pharmaceutical Target, Human Granulocyte‐Colony Stimulating Factor, in Nicotiana benthamiana Is Improved by Co‐Expression of the Transcriptional Regulator of the Unfolded Protein Response, bZIP60

Plant Biotechnology Journal, EarlyView.
Nazgul Wagner, Konstantin Musiychuk, Stephen Tottey, Jukka Kervinen, Hong Bi, Stephen J. Streatfield, Rainer Fischer, Vidadi Yusibov   +7 more
wiley   +1 more source

Nitric Oxide in Cancer: Mechanisms, Dual Role, and Therapeutic Strategies

MedComm – Oncology, Volume 5, Issue 3, September 2026.
Nitric oxide exerts concentration‐dependent dual roles in cancer, functioning as either a tumor promoter or suppressor. This review comprehensively examines NO's multifaceted regulation of tumor biology, including S‐nitrosylation signaling, metabolic reprogramming, immunemodulation, and therapy resistance, and highlights emerging therapeutic strategies
Jia Shao, Honghua Zhang, Jingyu Chen, Ziyu Qian, Ning Zhang, Yihua Zhang, Hui Ye, Jianbing Wu, Zhangjian Huang   +8 more
wiley   +1 more source

Ero1-PDI interactions, the response to redox flux and the implications for disulfide bond formation in the mammalian endoplasmic reticulum [PDF]

, 2013
The protein folding machinery of the endoplasmic reticulum (ER) ensures that proteins entering the eukaryotic secretory pathway acquire appropriate post-translational modifications and reach a stably folded state.
Sitia, R., Benham, A.M., Van Lith, M., Braakman, I., Lith, M. van, van Lith M, Braakman I., Benham AM, Cellular Protein Chemistry, SITIA , ROBERTO, Sub Cellular Protein Chemistry, Dep Scheikunde, Chemie van glyco-conjugaten   +12 more
core   +2 more sources

Edible Insect Allergens: An Emerging Food Safety Challenge

Sustainable Food Proteins, Volume 4, Issue 3, September 2026.
Allergic responses to edible insects arise via two main pathways: cross‐reactivity with homologous arthropod allergens and primary sensitization to edible insect proteins, both leading to IgE‐mediated immune activation. ABSTRACT Edible insects are increasingly promoted as sustainable protein sources; however, their allergenic potential remains a ...
Changqi Liu, Cassandra Maya, John J. Love, Huilian Che, Ke Chen, Jing Zhao   +5 more
wiley   +1 more source

Quantifying Changes in the Cellular Thiol-Disulfide Status during Differentiation of B Cells into Antibody-Secreting Plasma Cells [PDF]

, 2013
Plasma cells produce and secrete massive amounts of disulfide-containing antibodies. To accommodate this load on the secretory machinery, the differentiation of resting B cells into antibody-secreting plasma cells is accompanied by a preferential ...
Winther, J.R., Ineke Braakman, Braakman, I., Hansen, R.E., Cellular Protein Chemistry, Otsu, M., Otsu, Mieko, Hansen, Rosa Rebecca Erritzøe, Sub Cellular Protein Chemistry, Mieko Otsu, Winther, Jakob R., Braakman, Ineke, Rosa E. Hansen, Jakob R. Winther   +13 more
core   +1 more source