Results 121 to 130 of about 3,392,726 (209)

Combating ageing beyond the cell: Emerging roles of extracellular proteostasis

The FEBS Journal, Volume 293, Issue 18, Page 5558-5584, September 2026.
Ageing challenges the body's ability to maintain a stable and functional proteome, leading to protein damage and aggregation both inside and outside cells. This review focuses on the less well understood mechanisms of extracellular protein quality control and how they become disrupted in ageing, particularly in neurodegenerative diseases.
Siddharth R. Venkatesh, Ivan Gallotta, Bolanle F. Olabiyi, Yoon Hee Choi, Sarah Inglesfield, Janet R. Kumita, Collin Y. Ewald, Della C. David   +7 more
wiley   +1 more source

Exacerbated expansive vascular remodeling due to disturbed flow in male mice overexpressing protein disulfide isomerase‐A1

Physiological Reports, Volume 14, Issue 17, September 2026.
Abstract Vascular expansive remodeling is involved in atherosclerosis/restenosis; however, its mechanisms need further investigation. Protein‐disulfide isomerase (PDIA1), a redox chaperone from the endoplasmic reticulum and cell surface, supports vascular smooth muscle mechanoadaptation.
Júlia Martins Felipe de Souza, Tiphany Coralie De Bessa, Amanda de Almeida Silva, Carolina Gonçalves Fernandes, Leonardo Yuji Tanaka, Francisco Rafael Martins Laurindo   +5 more
wiley   +1 more source

The atypical thiol-disulfide exchange protein alpha-DsbA2 from Wolbachia pipientis is a homotrimeric disulfide isomerase

, 2019
Disulfide-bond-forming (DSB) oxidative folding enzymes are master regulators of virulence that are localized to the periplasm of many Gram-negative bacteria.
Whitten, Andrew E., Walden, Patricia M, Whitten, Andrew E, Halili, Maria A, Martin, Jennifer L, Halili, Maria A., Martin, Jennifer L., Premkumar, Lakshmanane, King, Gordon J., King, Gordon J, Heras, Begona, Walden, Patricia M.   +11 more
core   +1 more source

Protein disulfide isomerase-9 interacts with the lumenal region of the transmembrane endoplasmic reticulum stress sensor kinase, IRE1, to modulate the unfolded protein response in Arabidopsis

Frontiers in Plant Science
Environmental stressors disrupt secretory protein folding and proteostasis in the endoplasmic reticulum (ER), leading to ER stress. The unfolded protein response (UPR) senses ER stress and restores proteostasis by increasing the expression of ER-resident
Rina Carrillo, Kaela Iwai, Alena Albertson, Gabrielle Dang, David A. Christopher   +4 more
doaj   +1 more source

Protein disulfide isomerase is essential for spermatogenesis in mice

JCI Insight
Spermatogenesis requires precise posttranslational control in the endoplasmic reticulum (ER), but the mechanism remains largely unknown. The protein disulfide isomerase (PDI) family is a group of thiol oxidoreductases responsible for catalyzing the disulfide bond formation of nascent proteins. In this study, we generated 14 strains
Yaqiong Zhang, Aizhen Yang, Zhenzhen Zhao, Fengwu Chen, Xiaofeng Yan, Yue Han, Depei Wu, Yi Wu   +7 more
openaire   +2 more sources

Studies of protein post-translational modifications using high resolution tandem mass spectrometry [PDF]

Electron capture dissociation (ECD) is a powerful and superior tandem mass spectrometry (MS) fragmentation technique in the study of protein post-translational modifications (PTMs) due to its unique features of preserving labile modifications and ...
Li, Huilin
core  

Asparagine614 Determines the Transport and Function of the Murine Anti-Aging Protein Klotho

Cells
Klotho is an anti-aging protein whose deletion significantly reduces lifespan in mice, while its over-expression increases lifespan. Klotho is a type-I transmembrane protein that is N-glycosylated at eight positions within its ectodomain.
Zahra Fanaei-Kahrani, Christoph Kaether
doaj   +1 more source

Phenylhydrazone-based endoplasmic reticulum proteostasis regulator compounds with enhanced biological activity

eLife
Pharmacological enhancement of endoplasmic reticulum (ER) proteostasis is an attractive strategy to mitigate pathology linked to etiologically diverse protein misfolding diseases.
Gabriel M Kline, Lisa Boinon, Adrian Guerrero, Sergei Kutseikin, Gabrielle Cruz, Marnie P Williams, Ryan J Paxman, William E Balch, Jeffery W Kelly, Tingwei Mu, R Luke Wiseman   +10 more
doaj   +1 more source

Protein disulfide isomerases are promising targets for predicting the survival and tumor progression in glioma patients. [PDF]

Aging (Albany NY), 2020
Peng Z, Chen Y, Cao H, Zou H, Wan X, Zeng W, Liu Y, Hu J, Zhang N, Xia Z, Liu Z, Cheng Q.   +11 more
europepmc   +1 more source

The leader of the capsid protein from Feline calicivirus must be palmitoylated and form oligomers through disulfide bonds for efficient viral replication

Journal of Virology
Feline calicivirus (FCV), a member of the genus Vesivirus and a model for studying members of the family Caliciviridae, has been used to understand the biology and viral replication of etiological agents of medical and veterinary importance.
Yoatzin Peñaflor-Téllez, Jaury Gómez de la Madrid, Erick Ignacio Monge-Celestino, Carolina Pérez-Ibáñez, Randy Seir Llanas Vázquez, Sharon Itzel Sosa Mondragon, Carlos Emilio Miguel-Rodríguez, Ana Lorena Gutiérrez-Escolano   +7 more
doaj   +1 more source