Results 61 to 70 of about 3,392,726 (209)

Secretopathies emerge as a new class of neurocristopathies

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are a transient embryonic population of cells that give rise to a wide range of structures, including craniofacial cartilage and bone, peripheral neurons and glia, as well as components of the cardiac outflow tract, among others.
Amanda Teixeira, Cassandra Millet‐Boureima, Joshua A. Moore, Loydie A. Jerome‐Majewska   +3 more
wiley   +1 more source

Structural, functional and proteomic changes of proteins during rice yellowing

Food Chemistry: X
High temperature storage (40 °C, 60 % relative humidity, 6 months) induces rice yellowing and affects protein properties. Physiochemical analysis revealed increased disulfide bonds, particle size, and surface hydrophobicity in yellowed rice protein ...
Yuqian Liu, Yanan Qv, Jingyu Sun, Xiao Zheng, Victoria Anthony Uyanga, Yawen Wang, Yu Cui, Caiyun Tang, Jinguang Liu, Yilun Chen   +9 more
doaj   +1 more source

Lung epithelial protein disulfide isomerase A3 (PDIA3) plays an important role in influenza infection, inflammation, and airway mechanics

Redox Biology, 2019
Protein disulfide isomerases (PDI) are a family of redox chaperones that catalyze formation or isomerization of disulfide bonds in proteins. Previous studies have shown that one member, PDIA3, interacts with influenza A virus (IAV) hemagglutinin (HA ...
Nicolas Chamberlain, Bethany R. Korwin-Mihavics, Emily M. Nakada, Sierra R. Bruno, David E. Heppner, David G. Chapman, Sidra M. Hoffman, Albert van der Vliet, Benjamin T. Suratt, Oliver Dienz, John F. Alcorn, Vikas Anathy   +11 more
doaj   +1 more source

A point mutation in the Pdia6 gene results in loss of pancreatic β-cell identity causing overt diabetes

Molecular Metabolism, 2021
Objective: Protein disulfide isomerases (PDIs) are oxidoreductases that are involved in catalyzing the formation and rearrangement of disulfide bonds during protein folding.
Nirav Florian Chhabra, Anna–Lena Amend, Aimée Bastidas-Ponce, Sibylle Sabrautzki, Marta Tarquis-Medina, Stephan Sachs, Marina Rubey, Bettina Lorenz-Depiereux, Annette Feuchtinger, Mostafa Bakhti, Heiko Lickert, Gerhard K.H. Przemeck, Martin Hrabě de Angelis   +12 more
doaj   +1 more source

S100A9 promotes pulmonary arterial hypertension by regulating mitochondria–endoplasmic reticulum interaction‐mediated inflammatory injury of endothelial cells

Interdisciplinary Medicine, EarlyView.
Macrophage‐derived S100 calcium‐binding protein A9 (S100A9) promotes the pathological progression of pulmonary arterial hypertension (PAH). S100A9 upregulates the interaction between signal‐transducing adaptor protein 2 and leucine‐rich repeat kinase 2, thereby regulating mitochondria–endoplasmic reticulum (ER) contact.
Chen Gong, Long Chen, Yiting Zhao, Xiaohe Wang, Qiang Yuan, Xiaofeng Fang, Liuyi Li, Yinbo Xu, Shumei Jiang, Guangwen Xu, Ke Meng, Delong Wang, Kangli Cao, Jianlong Sheng, Liling Guo, Shichun Shen   +15 more
wiley   +1 more source

Disulfide isomerase ERp57 improves the stability and immunogenicity of H3N2 influenza virus hemagglutinin

Virology Journal, 2020
Background Hemagglutinin (HA), as the surface immunogenic protein, is the most important component of influenza viruses. Previous studies showed that the stability of HA was significant for HA’s immunogenicity, and many efforts have been made to ...
Jialing Wu, Yang Wang, Ying Wei, Zhichao Xu, Xin Tan, Zhihui Wu, Jing Zheng, George Dacai Liu, Yongchang Cao, Chunyi Xue   +9 more
doaj   +1 more source

WTAP‐Mediated m6A Modification of TXNDC5 mRNA Promotes Cervical Carcinogenesis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT WT1‐associated protein (WTAP), a core component of the methyltransferase complex, is involved in various tumor pathological processes, but its specific mechanism in cervical cancer (CC) remains unclear. This study, based on single‐cell transcriptomic data (including 3 CC and 2 normal tissues), constructed a CC microenvironment cell atlas ...
Ling Chen, Nuo‐Xin Hu, Zhao‐Ying Chen, Ke‐An Zhu, Wei Huang   +4 more
wiley   +1 more source

AGR2-mediated cell-cell communication controls the antiviral immune response by promoting the thiol oxidation of TRAF3

Redox Biology
Protein disulfide isomerases (PDIs) are essential catalysts for the formation and isomerization of disulfide bonds in diverse substrate proteins and exert multiple functions under pathophysiological conditions.
Mengqi Jia, Xiaojing Chen, Wenxue Guo, Dapeng Ma, Peng Wang, Huanmin Niu, Changhong Liu, Xianjuan Lin, QiQi Lu, Jing Wang, Xiaoxue Zheng, Qi Sun, Chengjiang Gao, Huiqing Yuan   +13 more
doaj   +1 more source

Variation in the Subcellular Localization and Protein Folding Activity among Arabidopsis thaliana Homologs of Protein Disulfide Isomerase

Biomolecules, 2013
Protein disulfide isomerases (PDIs) catalyze the formation, breakage, and rearrangement of disulfide bonds to properly fold nascent polypeptides within the endoplasmic reticulum (ER). Classical animal and yeast PDIs possess two catalytic thioredoxin-like
Christen Y. L. Yuen, David A. Christopher, Kristie O. Matsumoto   +2 more
doaj   +1 more source

Recent Advances (2023–2025) of Capillary Electrophoresis‐Mass Spectrometry (CE‐MS) for Top‐Down Proteomics

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Top‐down proteomics (TDP) characterizes proteoforms in cells, tissues, and biofluids, in discovery mode and on a global scale, requiring analytical tools with high peak capacity for proteoform separation and high sensitivity for proteoform detection, given the extremely high proteoform complexity and wide proteoform concentration dynamic range.
Guijie Zhu, David A. Alvarez Rodriguez, Noah Gould, Alexander R. Ivanov, Kevin Jooß, Liangliang Sun   +5 more
wiley   +1 more source