Results 101 to 110 of about 43,163 (273)

A Fungal Cysteine‐Rich Protein SsSCP Activates Immune Responses and Confers Broad‐Spectrum Disease Resistance in Tomato

Plant Biotechnology Journal, EarlyView.
ABSTRACT Plant immune systems recognise pathogen‐derived molecular patterns to activate defence responses, yet the mechanisms underlying fungal pattern recognition in crops remain largely unclear. Here, we characterise the cysteine‐rich secretory protein SsSCP from the broad‐host‐range fungal pathogen Sclerotinia sclerotiorum as a potent elicitor of ...
Liyuan Zhang, Yuan Wang, Yuhang Liu, Jinwen Yang, Kaihao Zhang, Chengzhang Du, Jiajing Xiao, Ling Qing, Xinhua Sun   +8 more
wiley   +1 more source

Mechanisms of Disulfide Bond Formation in Nascent Polypeptides Entering the Secretory Pathway

Cells, 2020
Disulfide bonds are an abundant feature of proteins across all domains of life that are important for structure, stability, and function. In eukaryotic cells, a major site of disulfide bond formation is the endoplasmic reticulum (ER).
Philip J. Robinson, Neil J. Bulleid
doaj   +1 more source

The Interplay between Chemistry and Mechanics in the Transduction of a Mechanical Signal into a Biochemical Function [PDF]

, 2007
There are many processes in biology in which mechanical forces are generated. Force-bearing networks can transduce locally developed mechanical signals very extensively over different parts of the cell or tissues.
Ainavarapu, Alon, Altmann, Baker, Barakat, Barsegov, Becker, Bell, Best, Best, Bhasin, Braun, Brockwell, Brooks, Brooks, Bruno Samorì, Bryant, Bustamante, Bustanji, Bustanji, Cao, Carl, Carrion-Vazquez, Carson, Chang, Chtcheglova, Cieplak, Cluzel, De Keulenaer, De Los Rios, Dembo, Dettmann, Dietz, Discher, Doggett, Doggett, Dudko, Ericson, Evans, Evans, Evans, Evans, Evans, Evans, Fantner, Fantner, Fenouillet, Fernandez, Finger, Fisher, Fisher, Fowler, Francesco Valle, Fritz, Gao, Grandi, Guo, Heslot, Higgins, Hotchkiss, Hsiai, Hummer, Hyeon, Jackson, Jiang, Julien, Kawakami, Kellermayer, Kozuka, Kung, Lambert-Vidmar, Lawler, Lawrence, Lay, Lee, Lenne, Li, Li, Li, Li, Li, Li, Lincoln, Liphardt, Liphardt, Lou, Lou, Makarov, Marshall, Marszalek, Massimo Sandal, Matouschek, Matthias, Merkel, Mohamed, Morrow, Neupert, Oberhauser, Oberhauser, Pereverzev, Prajapati, Prakash, Qin, Rief, Rief, Rief, Rief, Ritort, Rouzina, Rubartelli, Rubenstein, Samori, Samori, Sandal, Sarasa-Renedo, Sarkar, Sato, Schnepel, Schulze, Schwaiger, Sengupta, Shimaoka, Smith, Smith, Smith, Smith, Stathakis, Stetefeld, Terada, Thirumalai, Thomas, Thomas, Thompson, Viani, Vladescu, Vogel, Vogel, Vologodskii, Waite, Welsh, West, Wiita, Wilcox, Williams, Xie, Xie, Yago, Yan, Yersin, Yoshimori, Yuan, Zhu, Ziegler   +152 more
core   +1 more source

Quiescin Sulfhydryl Oxidase‐Like 1 Positively Regulates Seed Dormancy in Rice

Plant Biotechnology Journal, EarlyView.
ABSTRACT Seed dormancy is an adaptive strategy that enables plants to survive adverse environmental conditions. In agricultural contexts, an optimal level of dormancy is essential: Insufficient dormancy can result in preharvest sprouting, while excessive dormancy may lead to uneven germination and poor stand establishment in subsequent crops.
Tengfei Ma, Qian Wang, Tao Wu, Qixian Hao, Yunshuai Huang, Changling Mou, Rong Miao, Jie Lan, Fulin Zhang, Ping Wang, Ziyan Zhu, Kunhao Li, Jiawei Song, Chen Hu, Yingying Chen, Boliang Lu, Yiwan Wu, Shijia Liu, Ling Jiang, Jianmin Wan   +19 more
wiley   +1 more source

Natural Products Targeting Protein Disulfide Isomerases: New Frontiers for Diabetes, Cancer, and Coagulation

Food Frontiers
The protein disulfide isomerase (PDI) family comprises 21 members that have oxidase, reductase, isomerase, and foldase activities essential for human health and disease. Protein disulfide isomerase A4 (PDIA4) is the largest member in this family.
Yi‐San Lee, Catherine Ortega, Tien‐Fen Kuo, Greta Yang, Wen‐Chin Yang   +4 more
doaj   +1 more source

Improving End‐Use Quality Through Introducing Cysteines Into the Central Repeat Domain of High‐Molecular‐Weight Glutenin Subunit 1Dx2 in Bread Wheat

Plant Biotechnology Journal, EarlyView.
ABSTRACT In bread wheat (Triticum aestivum L.), cysteine (Cys) residues within the N‐ and C‐termini of high‐molecular‐weight glutenin subunits (HMW‐GSs) critically influence dough quality. However, the functional significance of Cys residue in their central repeat domain (CRD) remains unclear.
Bo Wei, Lujun Zhang, Renchun Fan, Qi Zhang, Jiazhu Sun, Changbin Yin, Dongcheng Liu, Xiukun Liu, Aifeng Liu, Yuling Jiao, Caixia Gao, Xu Jia, Xianping Wang, Aimin Zhang, Xinyou Cao, Daowen Wang, Xiangqi Zhang   +16 more
wiley   +1 more source

A humanized monoclonal antibody that inhibits platelet-surface ERp72 reveals a role for ERp72 in thrombosis [PDF]

, 2017
Background: Within the endoplasmic reticulum, thiol isomerase enzymes modulate the formation and rearrangement of disulphide bonds in newly folded proteins entering the secretory pathway to ensure correct protein folding.
Bicknell, A. B., Flora, G. D., Gibbins, J. M., Holbrook, L., Sahli, K., Sandhar, G. K., Sasikumar, P., Schenk, M. P., Stainer, A. R.   +8 more
core   +1 more source

Engineering Marker‐Free Lettuce Chloroplast Genome to Express Functional Glucagon‐Like Peptide‐1 Receptor Agonists Exenatide and Lixisenatide

Plant Biotechnology Journal, EarlyView.
Engineering of marker‐free lettuce chloroplast genome to express CTB‐Exenatide and CTB‐Lixisenatide for oral delivery. Upper panel: Chemically synthesised exenatide or lixisenatide require expensive production, purification, refrigeration and invasive delivery methods.
Rahul Singh, Henry Daniell
wiley   +1 more source

Protein Disulfide Isomerase Modulates the Activation of Thyroid Hormone Receptors

Frontiers in Endocrinology, 2019
Thyroid hormone receptors (TRs) are responsible for mediating thyroid hormone (T3 and T4) actions at a cellular level. They belong to the nuclear receptor (NR) superfamily and execute their main functions inside the cell nuclei as hormone-regulated ...
Jessica L. O. Campos, Jessica L. O. Campos, Tabata R. Doratioto, Tabata R. Doratioto, Natalia B. Videira, Natalia B. Videira, Helder V. Ribeiro Filho, Helder V. Ribeiro Filho, Fernanda A. H. Batista, Juliana Fattori, Nathalia de C. Indolfo, Nathalia de C. Indolfo, Marcel Nakahira, Marcio C. Bajgelman, Aleksandra Cvoro, Francisco R. M. Laurindo, Paul Webb, Ana Carolina M. Figueira   +17 more
doaj   +1 more source

Protein disulphide isomerase-induced refolding of sonochemically prepared Ribonuclease A microspheres [PDF]

, 2012
The present communication describes for the first time the development of Ribonuclease A (RNase A) microspheres using the sonochemical method followed by an enzymatic treatment with protein disulphide isomerase (PDI).
Donelli, Ilaria, Fernandes, Margarida M., Ferreira, Helena, Freddi, G., Paulo, Artur Cavaco, Silva, Raquel   +5 more
core   +1 more source