Results 11 to 20 of about 97,846 (317)
Frontiers in Immunology, 2022 BackgroundProtein disulfide isomerase A3 (PDIA3) is a member of the protein disulfide isomerase (PDI) family that participates in protein folding through its protein disulfide isomerase function.
Zewei Tu +18 more
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Roles of Protein Disulfide Isomerase in Breast Cancer [PDF]
Cancers, 2022 Protein disulfide isomerase (PDI) is the endoplasmic reticulum (ER)’s most abundant and essential enzyme and serves as the primary catalyst for protein folding. Due to its apparent role in supporting the rapid proliferation of cancer cells, the selective blockade of PDI results in apoptosis through sustained activation of UPR pathways. The functions of
Suhui Yang +8 more
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Mechanistic insights on the reduction of glutathione disulfide by protein disulfide isomerase [PDF]
Proceedings of the National Academy of Sciences, 2017 Significance Protein disulfide isomerase (PDI) is a ubiquitous enzyme involved in disulfide bond formation during protein folding. It has been related to neurological diseases (Parkinson or Alzheimer’s) because of unfolded protein response phenomena.
Rui P. P. Neves +2 more
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Inhibition of Protein Disulfide Isomerase in Thrombosis [PDF]
Basic & Clinical Pharmacology & Toxicology, 2016 AbstractThis MiniReview addresses our current understanding of the mechanisms by which protein disulfide isomerase (PDI) mediates thrombus formation and discusses the potential of blocking thrombosis by targeting PDI. Thiol isomerases are ubiquitous oxidoreductases primarily localized to the endoplasmic reticulum (ER) where they serve a critical role ...
Roelof H, Bekendam, Robert, Flaumenhaft
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Functions and mechanisms of protein disulfide isomerase family in cancer emergence [PDF]
Cell & Bioscience, 2022 The endoplasmic reticulum (ER) is a multi-layered organelle that is essential for the synthesis, folding, and structural maturation of almost one-third of the cellular proteome.
Nisa Syakila A. Rahman +5 more
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Protein disulfide isomerase in thrombosis and vascular inflammation [PDF]
Journal of Thrombosis and Haemostasis, 2013 Protein disulfide isomerase (PDI) catalyzes disulfide bond oxidation, reduction and isomerization during protein synthesis in the endoplasmic reticulum (ER). In addition to its critical role in the ER, in vitro and in vivo studies with blocking antibodies and conditional knockout mice have demonstrated that cell surface PDI is required for thrombosis ...
Jaehyung Cho
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Frontiers in Plant Science, 2018 Protein disulfide isomerase (PDI) catalyzes the conversion of thiol-disulfide and plays an important role in various physiological events in animals. A PDI (OaPDI) from a tropical plant was detailed studied and it was found to be involved in response of ...
Zhengrong Zhang +5 more
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Disturbed flow regulates protein disulfide isomerase A1 expression via microRNA-204 [PDF]
Frontiers in PhysiologyRedox processes can modulate vascular pathophysiology. The endoplasmic reticulum redox chaperone protein disulfide isomerase A1 (PDIA1) is overexpressed during vascular proliferative diseases, regulating thrombus formation, endoplasmic reticulum stress ...
Leonardo Y. Tanaka +7 more
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Tannic acid inhibits TNF-α signaling by targeting the protein disulfide isomerase and alleviates symptoms in an imiquimod-induced psoriasis mouse model. [PDF]
Cell Commun SignalJin W +16 more
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Synergies of phosphatidylserine and protein disulfide isomerase in tissue factor activation
Thrombosis and Haemostasis, 2014 Wolfram Ruf, Florian Langer
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