Roles of Protein Disulfide Isomerase in Breast Cancer [PDF]
Cancers, 2022 Protein disulfide isomerase (PDI) is the endoplasmic reticulum (ER)’s most abundant and essential enzyme and serves as the primary catalyst for protein folding. Due to its apparent role in supporting the rapid proliferation of cancer cells, the selective blockade of PDI results in apoptosis through sustained activation of UPR pathways. The functions of
Yanyuan Wu, Suhui Yang
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Mechanistic insights on the reduction of glutathione disulfide by protein disulfide isomerase [PDF]
Proceedings of the National Academy of Sciences, 2017 Significance Protein disulfide isomerase (PDI) is a ubiquitous enzyme involved in disulfide bond formation during protein folding. It has been related to neurological diseases (Parkinson or Alzheimer’s) because of unfolded protein response phenomena.
Rui P. P. Neves +2 more
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The human protein disulfide isomerase gene family [PDF]
Human Genomics, 2012 Enzyme-mediated disulfide bond formation is a highly conserved process affecting over one-third of all eukaryotic proteins. The enzymes primarily responsible for facilitating thiol-disulfide exchange are members of an expanding family of proteins known ...
Galligan James J, Petersen Dennis R
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Dual roles for a tick protein disulfide isomerase during the life cycle of the Lyme disease agent [PDF]
mBioThe protein disulfide isomerase (PDI) family is a group of enzymes that have thiol-disulfide oxidoreductase, disulfide isomerase, and redox-dependent chaperone activities.
Xiaotian Tang +5 more
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Unveiling the thioredoxin fold: a systematic review and bioinformatic analysis of protein disulfide isomerase and Dsb family proteins [PDF]
Frontiers in BioinformaticsIntroductionProtein Disulfide Isomerases (PDIs) and bacterial Dsb proteins are key members of the thioredoxin-fold superfamily, essential for oxidative protein folding in eukaryotic and prokaryotic systems, respectively.
Daniel Cuevas Ortiz +8 more
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Protein disulfide isomerase is essential for osteoblast differentiation in mice [PDF]
Communications BiologyProtein disulfide isomerase (PDI) is an oxidoreductase responsible for the formation, reduction and isomerization of disulfide bonds of nascent proteins in endoplasmic reticulum (ER).
Yue Lu +5 more
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Autodegradation of Protein Disulfide Isomerase [PDF]
Bioscience, Biotechnology, and Biochemistry, 1999 Protein disulfide isomerase (PDI) and its degradation products were found in HepG2, COS-1, and CHO-K1 cells. Whether or not the products were formed through autodegradation of PDI was examined, since PDI contains the CGHC motif, which is the active center of proteolytic activity in ER-60 protease.
URADE, Reiko +4 more
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Exacerbated expansive vascular remodeling due to disturbed flow in male mice overexpressing protein disulfide isomerase-A1. [PDF]
Physiol RepAbstract Vascular expansive remodeling is involved in atherosclerosis/restenosis; however, its mechanisms need further investigation. Protein‐disulfide isomerase (PDIA1), a redox chaperone from the endoplasmic reticulum and cell surface, supports vascular smooth muscle mechanoadaptation.
de Souza JMF +5 more
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PDI-Regulated Disulfide Bond Formation in Protein Folding and Biomolecular Assembly
Molecules, 2020 Disulfide bonds play a pivotal role in maintaining the natural structures of proteins to ensure their performance of normal biological functions. Moreover, biological molecular assembly, such as the gluten network, is also largely dependent on the ...
Jiahui Fu +3 more
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Frontiers in Immunology, 2022 BackgroundProtein disulfide isomerase A3 (PDIA3) is a member of the protein disulfide isomerase (PDI) family that participates in protein folding through its protein disulfide isomerase function.
Zewei Tu +18 more
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