Results 31 to 40 of about 97,846 (317)

Folding of a single domain protein entering the endoplasmic reticulum precedes disulfide formation [PDF]

, 2017
The relationship between protein synthesis, folding and disulfide formation within the endoplasmic reticulum (ER) is poorly understood. Previous studies have suggested pre-existing disulfide links are absolutely required to allow protein folding and ...
Bulleid, Neil J., Pringle, Marie Anne, Robinson, Philip J., Woolhead, Cheryl A.   +3 more
core   +1 more source

Novel Protein Disulfide Isomerase Inhibitor with Anticancer Activity in Multiple Myeloma [PDF]

Cancer Research, 2016
Sergei Vatolin, James G. Phillips, Babal K. Jha, Shravya Govindgari, Jennifer J. Hu, Dale Grabowski, Yvonne Parker, Daniel J. Lindner, Fei Zhong, Clark Distelhorst, Mitchell R. Smith, Claudiu Cotta, Yan Xu, Sujatha Chilakala, Rebecca R. Kuang, Samantha Tall, Frederic J. Reu   +16 more
openalex   +2 more sources

The thiol-disulfide exchange activity of AtPDI1 is involved in the response to abiotic stresses

BMC Plant Biology, 2021
Background Arabidopsis protein disulfide isomerase 1 (AtPDI1) has been demonstrated to have disulfide isomerase activity and to be involved in the stress response.
Ying Lu, Li Yuan, Zhou Zhou, Mengyu Wang, Xiaoyun Wang, Shizhong Zhang, Qinghua Sun   +6 more
doaj   +1 more source

Influence of ellagitannins extracted by pomegranate fruit on disulfide isomerase PDIA3 activity [PDF]

, 2019
Pomegranate fruit is a functional food of high interest for human health due to its wide range of phytochemicals with antioxidant properties are implicated in the prevention of inflammation and cancer. Ellagitannins, such as punicalagin and ellagic acid,
Altieri, Fabio, Cairone, Francesco, Carradori, Simone, Cesa, Stefania, Chichiarelli, Silvia, Giamogante, Flavia, Locatelli, Marcello   +6 more
core   +1 more source

A Protein Disulfide Isomerase Controls Neuronal Migration through Regulation of Wnt Secretion

Cell Reports, 2019
Summary: Appropriate Wnt morphogen secretion is required to control animal development and homeostasis. Although correct Wnt globular structure is essential for secretion, proteins that directly mediate Wnt folding and maturation remain uncharacterized ...
Nanna Torpe, Sandeep Gopal, Oguzhan Baltaci, Lorenzo Rella, Ava Handley, Hendrik C. Korswagen, Roger Pocock   +6 more
doaj   +1 more source

Folding of small disulfide-rich proteins : clarifying the puzzle [PDF]

, 2006
Premi a l'excel·lència investigadora. Àmbit de les Ciències Experimentals. 2008The process by which small proteins fold to their native conformations has been intensively studied over the last few decades.
Apuy, Arolas, Arolas, Arolas, Arolas, Baneyx, Bardwell, Cemazar, Cemazar, Chang, Chang, Chang, Chang, Chang, Chang, Chang, Chang, Chang, Chang, Chang, Chatrenet, Creighton, Creighton, Creighton, Creighton, Creighton, Daggett, Daly, Darby, Dobson, Ellgaard, Francesc X. Aviles, Fuller, Gehrmann, Goldberg, Goldenberg, Heitz, Hogg, Houry, Joan L. Arolas, Jui-Yoa Chang, Klein-Seetharaman, Kortemme, Kuhlman, Laity, Li, Lu, Matagne, Narayan, Narayan, Narayan, Narayan, Onuchic, Permyakov, Ross, Ruoppolo, Ruoppolo, Salamanca, Salvador Ventura, Scheraga, Shimotakahara, Shin, van den Berg, van den Berg, van Mierlo, van Mierlo, Venhudova, Wedemeyer, Weissman, Welker, Welker, Wu, Yang, Zavodszky   +73 more
core   +2 more sources

Reversal of Alpha-Synuclein Fibrillization by Protein Disulfide Isomerase

Frontiers in Cell and Developmental Biology, 2020
Aggregates of α-synuclein contribute to the etiology of Parkinson’s Disease. Protein disulfide isomerase (PDI), a chaperone and oxidoreductase, blocks the aggregation of α-synuclein.
Albert Serrano, Xin Qiao, Jason O. Matos, Lauren Farley, Lucia Cilenti, Bo Chen, Suren A. Tatulian, Ken Teter   +7 more
doaj   +1 more source

A novel reaction of peroxiredoxin 4 towards substrates in oxidative protein folding. [PDF]

PLoS ONE, 2014
Peroxiredoxin 4 (Prx4) is the only endoplasmic reticulum localized peroxiredoxin. It functions not only to eliminate peroxide but also to promote oxidative protein folding via oxidizing protein disulfide isomerase (PDI).
Li Zhu, Kai Yang, Xi'e Wang, Xi Wang, Chih-chen Wang   +4 more
doaj   +1 more source

Immunoproteomic to identify antigens in the intestinal mucosa of Crohn's disease patients. [PDF]

PLoS ONE, 2013
Incidences of Crohn disease (CD) have increased significantly in the last decade. Immunoproteomics are a promising method to identify biomarkers of different diseases. In the present study, we used immunoproteomics to study proteins of intestinal mucosal
Zheng Zhou, Haiyan Liu, Guosheng Gu, Gefei Wang, Wenyong Wu, Changle Zhang, Jianan Ren   +6 more
doaj   +1 more source

Participation of the endoplasmic reticulum protein chaperone thio-oxidoreductase in gonadotropin-releasing hormone receptor expression at the plasma membrane

Brazilian Journal of Medical and Biological Research, 2009
Chaperone members of the protein disulfide isomerase family can catalyze the thiol-disulfide exchange reaction with pairs of cysteines. There are 14 protein disulfide isomerase family members, but the ability to catalyze a thiol disulfide exchange ...
W. Lucca-Junior, J.A. Janovick, P.M. Conn   +2 more
doaj   +1 more source