Results 61 to 70 of about 83,411 (273)

Activation of the Unfolded Protein Response via Inhibition of Protein Disulfide Isomerase Decreases the Capacity for DNA Repair to Sensitize Glioblastoma to Radiotherapy.

Cancer Research, 2019
Patients with glioblastoma multiforme (GBM) survive on average 12 to 14 months after diagnosis despite surgical resection followed by radiotheraphy and temozolomide therapy.
Yajing Liu, W. Ji, Andrea G Shergalis, Jiaqi Xu, Amy M. Delaney, A. Calcaterra, Anupama Pal, M. Ljungman, N. Neamati, A. Rehemtulla   +9 more
semanticscholar   +1 more source

Influence of ellagitannins extracted by pomegranate fruit on disulfide isomerase PDIA3 activity [PDF]

, 2019
Pomegranate fruit is a functional food of high interest for human health due to its wide range of phytochemicals with antioxidant properties are implicated in the prevention of inflammation and cancer. Ellagitannins, such as punicalagin and ellagic acid,
Altieri, Fabio, Cairone, Francesco, Carradori, Simone, Cesa, Stefania, Chichiarelli, Silvia, Giamogante, Flavia, Locatelli, Marcello   +6 more
core   +1 more source

The transmembrane protein disulfide isomerase TMX1 negatively regulates platelet responses.

Blood, 2019
Secreted platelet protein disulfide isomerases, PDI, ERp57, ERp5, and ERp72, have important roles as positive regulators of platelet function and thrombosis.
Zhenzhen Zhao, Yi Wu, Junsong Zhou, Fengwu Chen, Aizhen Yang, D. Essex   +5 more
semanticscholar   +1 more source

The Interplay between Chemistry and Mechanics in the Transduction of a Mechanical Signal into a Biochemical Function [PDF]

, 2007
There are many processes in biology in which mechanical forces are generated. Force-bearing networks can transduce locally developed mechanical signals very extensively over different parts of the cell or tissues.
Ainavarapu, Alon, Altmann, Baker, Barakat, Barsegov, Becker, Bell, Best, Best, Bhasin, Braun, Brockwell, Brooks, Brooks, Bruno Samorì, Bryant, Bustamante, Bustanji, Bustanji, Cao, Carl, Carrion-Vazquez, Carson, Chang, Chtcheglova, Cieplak, Cluzel, De Keulenaer, De Los Rios, Dembo, Dettmann, Dietz, Discher, Doggett, Doggett, Dudko, Ericson, Evans, Evans, Evans, Evans, Evans, Evans, Fantner, Fantner, Fenouillet, Fernandez, Finger, Fisher, Fisher, Fowler, Francesco Valle, Fritz, Gao, Grandi, Guo, Heslot, Higgins, Hotchkiss, Hsiai, Hummer, Hyeon, Jackson, Jiang, Julien, Kawakami, Kellermayer, Kozuka, Kung, Lambert-Vidmar, Lawler, Lawrence, Lay, Lee, Lenne, Li, Li, Li, Li, Li, Li, Lincoln, Liphardt, Liphardt, Lou, Lou, Makarov, Marshall, Marszalek, Massimo Sandal, Matouschek, Matthias, Merkel, Mohamed, Morrow, Neupert, Oberhauser, Oberhauser, Pereverzev, Prajapati, Prakash, Qin, Rief, Rief, Rief, Rief, Ritort, Rouzina, Rubartelli, Rubenstein, Samori, Samori, Sandal, Sarasa-Renedo, Sarkar, Sato, Schnepel, Schulze, Schwaiger, Sengupta, Shimaoka, Smith, Smith, Smith, Smith, Stathakis, Stetefeld, Terada, Thirumalai, Thomas, Thomas, Thompson, Viani, Vladescu, Vogel, Vogel, Vologodskii, Waite, Welsh, West, Wiita, Wilcox, Williams, Xie, Xie, Yago, Yan, Yersin, Yoshimori, Yuan, Zhu, Ziegler   +152 more
core   +1 more source

Oxidative protein biogenesis and redox regulation in the mitochondrial intermembrane space [PDF]

, 2016
Mitochondria are organelles that play a central role in cellular metabolism, as they are responsible for processes such as iron/sulfur cluster biogenesis, respiration and apoptosis.
MacPherson, Lisa, Manganas, Phanee, Tokatlidis, Kostas   +2 more
core   +1 more source

Oxidative Protein-Folding Systems in Plant Cells

International Journal of Cell Biology, 2013
Plants are unique among eukaryotes in having evolved organelles: the protein storage vacuole, protein body, and chloroplast. Disulfide transfer pathways that function in the endoplasmic reticulum (ER) and chloroplasts of plants play critical roles in the
Yayoi Onda
doaj   +1 more source

The thiosemicarbazone Me2NNMe2 induces paraptosis by disrupting the ER thiol redox homeostasis based on protein disulfide isomerase inhibition

Cell Death and Disease, 2018
Due to their high biological activity, thiosemicarbazones have been developed for treatment of diverse diseases, including cancer, resulting in multiple clinical trials especially of the lead compound Triapine.
Sonja Hager, Katharina Korbula, Björn Bielec, M. Grusch, C. Pirker, M. Schosserer, L. Liendl, Magdalena Lang, J. Grillari, K. Nowikovsky, Veronika F. S. Pape, T. Mohr, G. Szakács, B. Keppler, W. Berger, C. Kowol, P. Heffeter   +16 more
semanticscholar   +1 more source

Pre-expression of a sulfhydryl oxidase significantly increases the yields of eukaryotic disulfide bond containing proteins expressed in the cytoplasm of E.coli

Microbial Cell Factories, 2011
Background Disulfide bonds are one of the most common post-translational modifications found in proteins. The production of proteins that contain native disulfide bonds is challenging, especially on a large scale.
Enlund Eveliina, Salo Kirsi EH, Hatahet Feras, Nguyen Van, Zhang Chi, Ruddock Lloyd W   +5 more
doaj   +1 more source

Orphan proteins of unknown function in the mitochondrial intermembrane space proteome: new pathways and metabolic cross-talk [PDF]

, 2016
The mitochondrial intermembrane space (IMS) is involved in protein transport, lipid homeostasis and metal ion exchange, while further acting in signalling pathways such as apoptosis.
Manganas, Phanee, Nuebel, Esther, Tokatlidis, Konstantinos   +2 more
core   +1 more source

The Unfolded Protein Response and the Role of Protein Disulfide Isomerase in Neurodegeneration

Front. Cell Dev. Biol., 2016
The maintenance and regulation of proteostasis is a critical function for post-mitotic neurons and its dysregulation is increasingly implicated in neurodegenerative diseases. Despite having different clinical manifestations, these disorders share similar
E. Perri, Colleen J. Thomas, S. Parakh, D. Spencer, J. Atkin   +4 more
semanticscholar   +1 more source