Results 71 to 80 of about 16,988,925 (342)
Vein fate determined by flow-based but time-delayed integration of network architecture
eLife, 2023 Veins in vascular networks, such as in blood vasculature or leaf networks, continuously reorganize, grow or shrink, to minimize energy dissipation. Flow shear stress on vein walls has been set forth as the local driver for a vein’s continuous adaptation.
Sophie Marbach +4 more
doaj +1 more source
Electric Fields and Fast Protein Dynamics in Enzymes
Journal of Physical Chemistry Letters, 2017 In recent years, there has been much discussion regarding the origin of enzymatic catalysis and whether including protein dynamics is necessary for understanding catalytic enhancement.
I. Zoi, D. Antoniou, S. Schwartz
semanticscholar +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Predicting the Dynamics of Protein Abundance
Molecular & Cellular Proteomics, 2014 La síntesis de proteínas está finamente regulada en todos los organismos, desde las bacterias hasta los humanos, y su integridad sustenta muchos procesos importantes. La evidencia emergente sugiere que el rango dinámico de abundancia de proteínas es mayor que el observado a nivel de transcripción.
Ahmed M. Mehdi +3 more
openaire +5 more sources
Protein-induced changes in DNA structure and dynamics observed with noncovalent site-directed spin-labeling and PELDOR [PDF]
, 2012 Site-directed spin labeling and pulsed electron–electron double resonance (PELDOR or DEER) have previously been applied successfully to study the structure and dynamics of nucleic acids. Spin labeling nucleic acids at specific sites requires the covalent
Reginsson, Gunnar Widtfeldt +5 more
core +1 more source
Towards a Stochastic Paradigm: From Fuzzy Ensembles to Cellular Functions
Molecules, 2018 The deterministic sequence → structure → function relationship is not applicable to describe how proteins dynamically adapt to different cellular conditions. A stochastic model is required to capture functional promiscuity, redundant sequence
Monika Fuxreiter
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Hsp90 Breaks the Deadlock of the Hsp70 Chaperone System [PDF]
, 2018 Protein folding in the cell requires ATP-driven chaperone machines such as the conserved Hsp70 and Hsp90. It is enigmatic how these machines fold proteins.
Mayer, Matthias +5 more
core +2 more sources
Cytosolic calcium regulates cytoplasmic accumulation of TDP-43 through Calpain-A and Importin α3
eLife, 2020 Cytoplasmic accumulation of TDP-43 in motor neurons is the most prominent pathological feature in amyotrophic lateral sclerosis (ALS). A feedback cycle between nucleocytoplasmic transport (NCT) defect and TDP-43 aggregation was shown to contribute to ...
Jeong Hyang Park +12 more
doaj +1 more source
Ab initio characterization of protein molecular dynamics with AI2BMD
NatureBiomolecular dynamics simulation is a fundamental technology for life sciences research, and its usefulness depends on its accuracy and efficiency1, 2–3. Classical molecular dynamics simulation is fast but lacks chemical accuracy4,5.
Tong Wang +14 more
semanticscholar +1 more source