Results 61 to 70 of about 1,442,239 (292)

Cytosolic calcium regulates cytoplasmic accumulation of TDP-43 through Calpain-A and Importin α3

eLife, 2020
Cytoplasmic accumulation of TDP-43 in motor neurons is the most prominent pathological feature in amyotrophic lateral sclerosis (ALS). A feedback cycle between nucleocytoplasmic transport (NCT) defect and TDP-43 aggregation was shown to contribute to ...
Jeong Hyang Park, Chang Geon Chung, Sung Soon Park, Davin Lee, Kyung Min Kim, Yeonjin Jeong, Eun Seon Kim, Jae Ho Cho, Yu-Mi Jeon, C-K James Shen, Hyung-Jun Kim, Daehee Hwang, Sung Bae Lee   +12 more
doaj   +1 more source

Dynamics of protein-protein encounter: a Langevin equation approach with reaction patches

, 2008
We study the formation of protein-protein encounter complexes with a Langevin equation approach that considers direct, steric and thermal forces.
Alberts B., Denitsa Alamanova, Helms V., Hughes B. D., Jakob Schluttig, Smoluchowski M., Ulrich S. Schwarz, Volkhard Helms   +7 more
core   +1 more source

Molecular Dynamics Studies on the Buffalo Prion Protein [PDF]

, 2015
It was reported that buffalo is a low susceptibility species resisting to prion diseases, which are invariably fatal and highly infectious neurodegenerative diseases that affect a wide variety of species.
Chatterjee, Subhojyoti, Wang, Feng, Zhang, Jiapu   +2 more
core   +3 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Structural basis of Gip1 for cytosolic sequestration of G protein in wide-range chemotaxis

Nature Communications, 2018
Gip1 sequesters heterotrimeric G proteins in the cytosolic pool which regulates G protein-coupled receptor signalling for eukaryotic chemotaxis. Here the authors provide the crystal structure of Gip1's G protein-binding region and show that mutations in ...
Takero Miyagawa, Hiroyasu Koteishi, Yoichiro Kamimura, Yukihiro Miyanaga, Kohei Takeshita, Atsushi Nakagawa, Masahiro Ueda   +6 more
doaj   +1 more source

Identification of TCR repertoires in functionally competent cytotoxic T cells cross-reactive to SARS-CoV-2

Communications Biology, 2021
Kanako Shimizu et al. identify HLA-A24 high-binding epitopes in the SARS-CoV-2 spike region and investigate their cross-reactivity with CD8+ T cell receptors.
Kanako Shimizu, Tomonori Iyoda, An Sanpei, Hiroshi Nakazato, Masahiro Okada, Shogo Ueda, Miyuki Kato-Murayama, Kazutaka Murayama, Mikako Shirouzu, Naoko Harada, Michihiro Hidaka, Shin-ichiro Fujii   +11 more
doaj   +1 more source

Probing protein-protein interactions by dynamic force correlated spectroscopy (FCS)

, 2005
We develop a formalism for single molecule dynamic force spectroscopy to map the energy landscape of protein-protein complex ($P_1$$P_2$). The joint distribution $P(\tau_1,\tau_2)$ of unbinding lifetimes $\tau_1$ and $\tau_2$ measurable in a compression ...
A. Ashkin, D. Thirumalai, G. I. Bell, S. Shu, V. Barsegov   +4 more
core   +1 more source

A self-organized model for cell-differentiation based on variations of molecular decay rates [PDF]

, 2012
Systemic properties of living cells are the result of molecular dynamics governed by so-called genetic regulatory networks (GRN). These networks capture all possible features of cells and are responsible for the immense levels of adaptation ...
A Bhattacharjya, A Bossi, A Ciechanover, A Hoffmann, A Visel, AC Gavin, AP Capaldi, AU Viretta, B de Chassey, B Schwanhäusser, CC Guet, CG Langton, D Bratsun, D Das, D Ropers, D Stokić, EL Greer, EM Ozbudak, G Yagil, GM Church, H de Jong, H Kitano, I Shmulevich, J Gertz, J Gsponer, J Paulsson, JE Lee, JH Park, L Glass, L Glass, L Hood, L Pirkkala, M Mitchell, M Ptashne, M Rewieński, MA Beer, Manfred Pöchacker, Manuel Schölling, MB Burg, MJ Amorim, N Kashtan, NM Luscombe, P Smolen, Peter Csermely, R Casey, R Hanel, R Jothi, R Métivier, R Métivier, RP Zinzen, Rudolf Hanel, S Pigolotti, S Semsey, SA Kauffman, SA Vokes, Stefan Thurner, TE Turner, TI Lee, TR Burkard, X Qian, Z Tothova   +60 more
core   +4 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Protein Dynamics by Neutron Scattering: The Protein Dynamical Transition [PDF]

Biophysical Journal, 2012
Despite recent extensive efforts, the nature of the dynamics of biological macromolecules still remains unclear. in particular, contradicting models have been proposed for explaining the temperature behavior of the mean square displacement, MSD, and of the characteristic system time, τ.
Benedetto, Antonio, Migliardo, Federica, Magazù, Salvatore   +2 more
openaire   +1 more source