Results 61 to 70 of about 827,705 (313)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Simulating the Peptide Folding Kinetic Related Spectra Based on the Markov State Model [PDF]

, 2014
Optical spectroscopic tools are used to monitor protein folding/unfolding dynamics after a fast triggering such as the laser induced temperature jump. These techniques provide new opportunities for comparison between theory and simulations and atom-level
Han, KL, Zhuang, Wei, Yang, MJ, Zhang, X, Song, Jian   +4 more
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Predicting the Dynamics of Protein Abundance

Molecular & Cellular Proteomics, 2014
La síntesis de proteínas está finamente regulada en todos los organismos, desde las bacterias hasta los humanos, y su integridad sustenta muchos procesos importantes. La evidencia emergente sugiere que el rango dinámico de abundancia de proteínas es mayor que el observado a nivel de transcripción.
Ahmed M. Mehdi, Ralph Patrick, Timothy L. Bailey, Mikael Bodén   +3 more
openaire   +5 more sources

Profiling of dynamics in protein–lipid–water systems: a time-resolved fluorescence study of a model membrane protein with the label BADAN at specific membrane depths [PDF]

, 2009
Profiles of lipid-water bilayer dynamics were determined from picosecond time-resolved fluorescence spectra of membrane-embedded BADAN-labeled M13 coat protein. For this purpose, the protein was labeled at seven key positions.
Hoek, A., van, Stokkum, I.H.M. van, Ruud B. Spruijt, van Hoek, A., Koehorst, Rob B. M., Hemminga, M.A., Ivo H. M. Stokkum, Spruijt, R.B., van Stokkum, I.H.M., Bart van Oort, van Oort, B.F., Amerongen, H. van, Oort, B.F., van, Herbert van Amerongen, Koehorst, R.B.M., Rob B. M. Koehorst, van Amerongen, H., Laptenok, S., Hoek, A. van, Amerongen, H., van, Ivo H. M. van Stokkum, Stokkum, I.H.M., van, Herbert Amerongen, Arie van Hoek, van Oort, B.F.; id_orcid, Oort, B.F. van, Arie Hoek, van Stokkum, I.H.M.; id_orcid, Marcus A. Hemminga, Bart Oort, Sergey Laptenok   +30 more
core   +1 more source

Towards a Stochastic Paradigm: From Fuzzy Ensembles to Cellular Functions

Molecules, 2018
The deterministic sequence → structure → function relationship is not applicable to describe how proteins dynamically adapt to different cellular conditions. A stochastic model is required to capture functional promiscuity, redundant sequence
Monika Fuxreiter
doaj   +1 more source

Cytosolic calcium regulates cytoplasmic accumulation of TDP-43 through Calpain-A and Importin α3

eLife, 2020
Cytoplasmic accumulation of TDP-43 in motor neurons is the most prominent pathological feature in amyotrophic lateral sclerosis (ALS). A feedback cycle between nucleocytoplasmic transport (NCT) defect and TDP-43 aggregation was shown to contribute to ...
Jeong Hyang Park, Chang Geon Chung, Sung Soon Park, Davin Lee, Kyung Min Kim, Yeonjin Jeong, Eun Seon Kim, Jae Ho Cho, Yu-Mi Jeon, C-K James Shen, Hyung-Jun Kim, Daehee Hwang, Sung Bae Lee   +12 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Dynamic Prestress in a Globular Protein

PLoS Computational Biology, 2012
A protein at equilibrium is commonly thought of as a fully relaxed structure, with the intra-molecular interactions showing fluctuations around their energy minimum. In contrast, here we find direct evidence for a protein as a molecular tensegrity structure, comprising a balance of tensed and compressed interactions, a concept that has been put forward
Scott A. Edwards, Johannes A. Wagner, Frauke Gräter   +2 more
openaire   +5 more sources

Protein Dynamics and Drug Design: The Role of Molecular Simulations [PDF]

, 2010
The motions of proteins underlie all processes in cells, ranging from substrate transport to signal transmission, trafficking, formation of complexes and catalysis.
Morra G, Giulia Morra, Genoni A, Colombo G, Giorgio Colombo, Alessandro Genoni   +5 more
core   +1 more source