Results 51 to 60 of about 1,442,239 (292)
Vein fate determined by flow-based but time-delayed integration of network architecture
eLife, 2023 Veins in vascular networks, such as in blood vasculature or leaf networks, continuously reorganize, grow or shrink, to minimize energy dissipation. Flow shear stress on vein walls has been set forth as the local driver for a vein’s continuous adaptation.
Sophie Marbach +4 more
doaj +1 more source
Identifying the protein folding nucleus using molecular dynamics [PDF]
, 2000 Molecular dynamics simulations of folding in an off-lattice protein model reveal a nucleation scenario, in which a few well-defined contacts are formed with high probability in the transition state ensemble of conformations.
Buldyrev, Sergey V. +3 more
core +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
How membranes shape up for lipid transfer
eLifeThe extraction of a phospholipid called phosphatidic acid from the mitochondrial outer membrane is regulated by the curvature of this membrane.
Takashi Hirashima, Toshiya Endo
doaj +1 more source
Stochastic single-molecule dynamics of synaptic membrane protein domains
, 2016 Motivated by single-molecule experiments on synaptic membrane protein domains, we use a stochastic lattice model to study protein reaction and diffusion processes in crowded membranes.
Haselwandter, Christoph A. +2 more
core +1 more source
USP15 regulates dynamic protein-protein interactions of the spliceosome through deubiquitination of PRP31. [PDF]
, 2017 Post-translational modifications contribute to the spliceosome dynamics by facilitating the physical rearrangements of the spliceosome. Here, we report USP15, a deubiquitinating enzyme, as a regulator of protein-protein interactions for the spliceosome ...
Das, Tanuza +6 more
core +1 more source
Dynamics of protein hydration water [PDF]
Physical Review E, 2015 We present the frequency- and temperature-dependent dielectric properties of lysozyme solutions in a broad concentration regime, measured at subzero temperatures and compare the results with measurements above the freezing point of water and on hydrated lysozyme powder.
Wolf, M. +4 more
openaire +4 more sources
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Characterization of the Transition State of Functional Enzyme Dynamics [PDF]
, 2006 Through characterization of the solvent isotope effect on protein dynamics, we have examined determinants of the rate limitation to enzyme catalysis. A global conformational change in Ribonuclease A limits the overall rate of catalytic turnover.
Kovriguine, Evgueni, Loria, J. Patrick
core +2 more sources
Towards a Stochastic Paradigm: From Fuzzy Ensembles to Cellular Functions
Molecules, 2018 The deterministic sequence → structure → function relationship is not applicable to describe how proteins dynamically adapt to different cellular conditions. A stochastic model is required to capture functional promiscuity, redundant sequence
Monika Fuxreiter
doaj +1 more source