Results 51 to 60 of about 16,988,925 (342)
Conformational dynamics of the human serotonin transporter during substrate and drug binding
Nature Communications, 2019 The serotonin transporter (SERT) is responsible for re-uptake of serotonin into the presynaptic neuron and plays a key role in synaptic transmission. Here, the authors use hydrogen-deuterium exchange mass spectrometry to probe the conformational dynamics
Ingvar R. Möller +6 more
doaj +1 more source
Spatial and temporal analysis of PCP protein dynamics during neural tube closure
eLife, 2018 Planar cell polarity (PCP) controls convergent extension and axis elongation in all vertebrates. Although asymmetric localization of PCP proteins is central to their function, we understand little about PCP protein localization during convergent ...
Mitchell T. Butler, John B. Wallingford
semanticscholar +1 more source
CHAPTER 1.1. Disulfide Bonds in Protein Folding and Stability [PDF]
, 2018 Disulfide bonds are unique among post-translational modifications, as they add covalent crosslinks to the polypeptide chain. Accordingly, they can exert pronounced effects on protein folding and stability. This is of particular importance for secreted or
Sub Cellular Protein Chemistry +7 more
core +1 more source
Nature Communications, 2019 The formation of cilia depends on centriole’s distal appendages. Here, the authors use correlative 3D-superresolution, electron microscopy and electron tomography to detail the architecture of distal appendages, to describe the initial stages of ...
Mathew Bowler +9 more
doaj +1 more source
Emergence of behaviour in a self-organized living matter network
eLife, 2022 What is the origin of behaviour? Although typically associated with a nervous system, simple organisms also show complex behaviours. Among them, the slime mold Physarum polycephalum, a giant single cell, is ideally suited to study emergence of behaviour.
Philipp Fleig +3 more
doaj +1 more source
Functional protein dynamics in a crystal. [PDF]
Nat Commun, 2023 Abstract Proteins are molecular machines and to understand how they work, we need to understand how they move. New pump-probe time-resolved X-ray diffraction methods open up ways to initiate and observe protein motions with atomistic detail in crystals on biologically relevant timescales.
Klyshko E +6 more
europepmc +6 more sources
Protein Dynamics in Solution by Quantitative Crosslinking/Mass Spectrometry
TIBS -Trends in Biochemical Sciences. Regular ed, 2018 The dynamics of protein structures and their interactions are responsible for many cellular processes. The rearrangements and interactions of proteins, which are often transient, occur in solution and may require a biological environment that is ...
Zhuo A. Chen, J. Rappsilber
semanticscholar +1 more source
Nature CommunicationsWe describe a modified version of AlphaFold2 that incorporates experimental distance distributions into the network architecture for protein structure prediction.
Tianqi Wu +4 more
doaj +1 more source
Nature Communications, 2022 Iron is an essential mineral in plant physiology. YS1 transporter imports iron–phytosiderophore complex (Fe(III)–DMA) from the soil. Here, the authors describe the cryo-EM structures of barley YS1 in complex with substrate, and a synthetic substrate ...
Atsushi Yamagata +5 more
doaj +1 more source
FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source