Results 41 to 50 of about 827,705 (313)
Nature Communications, 2019 The formation of cilia depends on centriole’s distal appendages. Here, the authors use correlative 3D-superresolution, electron microscopy and electron tomography to detail the architecture of distal appendages, to describe the initial stages of ...
Mathew Bowler +9 more
doaj +1 more source
Emergence of behaviour in a self-organized living matter network
eLife, 2022 What is the origin of behaviour? Although typically associated with a nervous system, simple organisms also show complex behaviours. Among them, the slime mold Physarum polycephalum, a giant single cell, is ideally suited to study emergence of behaviour.
Philipp Fleig +3 more
doaj +1 more source
Nature CommunicationsWe describe a modified version of AlphaFold2 that incorporates experimental distance distributions into the network architecture for protein structure prediction.
Tianqi Wu +4 more
doaj +1 more source
Nature Communications, 2022 Iron is an essential mineral in plant physiology. YS1 transporter imports iron–phytosiderophore complex (Fe(III)–DMA) from the soil. Here, the authors describe the cryo-EM structures of barley YS1 in complex with substrate, and a synthetic substrate ...
Atsushi Yamagata +5 more
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Natural Killer Cells in Paediatric Soft Tissue Sarcomas: A Systematic Review
Pediatric Blood &Cancer, EarlyView.ABSTRACT Paediatric soft tissue sarcomas (pSTS) are a rare and heterogeneous group of malignant tumours arising in tissues of mesenchymal origin. The role of natural killer (NK) cells in pSTS remains poorly understood, with evidence fragmented across small preclinical studies and early‐phase clinical trials.
Raya Dean +7 more
wiley +1 more source
Protein Dynamics and its Correlation to Protein Activity and Stability [PDF]
, 2009 The aim of this thesis is to investigate the role of fast protein dynamics (picosecond timescale) in enzyme activity and stability, and specifically to test the hypothesis that enzyme activity and stability are inversely related by their internal ...
Clement, David
core
Pathogenic mutations in the hydrophobic core of the human prion protein can promote structural instability and misfolding [PDF]
, 2010 Transmissible spongiform encephalopathies, or prion diseases, are caused by misfolding and aggregation of the prion protein PrP. These diseases can be hereditary in humans and four of the many disease-associated missense mutants of PrP are in the ...
Valerie Daggett +3 more
core +1 more source
Integrating Protein Dynamics And Enhanced Conformational Ensembles To Better Understand Their Role In Biomolecular Function [PDF]
, 2020 Proteins have been termed the building blocks of life due to their involvement in practically every biological process that occurs in a living organism. For years now, researchers have sought to uncover the underlying mechanisms employed by biomolecules ...
Rodriguez-Bussey, Isela
core +2 more sources
Nature CommunicationsProtein conformational changes are the cornerstone of biological function. While conformers captured experimentally represent metastable states, the pathways connecting them have been elusive for experiments and simulations alike.
Domenico Scaramozzino +2 more
doaj +1 more source
A Bibliometric Analysis of Publications in Uremic Toxins From 1991 to 2024
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Background Uremic toxins are a growing area of research in nephrology, with significant implications in the progression and treatment of chronic kidney disease (CKD) and the management of end‐stage kidney disease (ESKD). This bibliometric analysis aims to evaluate the global research trends, key contributors, and the impact of publications in ...
Yuh‐Shan Ho +7 more
wiley +1 more source