Molecular dynamics decomposition of temperature-dependent elastic neutron scattering by a protein solution [PDF]
, 2003 Molecular dynamics simulations are performed of bovine pancreatic trypsin inhibitor in a cryosolution over a range of temperatures from 80 to 300 K and the origins identified of elastic dynamic neutron scattering from the solution. The elastic scattering
Smith, Jeremy C. +7 more
core +1 more source
Substrate-induced conformational dynamics of the dopamine transporter
Nature Communications, 2019 The dopamine transporter is responsible for termination of neurotransmission through Na+-driven reuptake of neurotransmitter from the extracellular space. Here authors use hydrogen-deuterium exchange mass spectrometry to monitor Na+- and dopamine-induced
Anne Kathrine Nielsen +6 more
doaj +1 more source
Epigenetic mechanisms to propagate histone acetylation by p300/CBP
Nature Communications, 2023 Histone acetylation is important for the activation of gene transcription but little is known about its direct read/write mechanisms. Here, we report cryogenic electron microscopy structures in which a p300/CREB-binding protein (CBP) multidomain monomer ...
Masaki Kikuchi +8 more
doaj +1 more source
Two domains of Tim50 coordinate translocation of proteins across the two mitochondrial membranes
Life Science Alliance, 2023 Biochemical and genetic experiments identify distinct roles of the two domains of Tim50 in the intermembrane space during translocation of proteins into the mitochondria via the TOM and TIM23 complexes.
Marcel G Genge +7 more
doaj +1 more source
AlphaFold2 models indicate that protein sequence determines both structure and dynamics
Scientific Reports, 2022 AlphaFold 2 (AF2) has placed Molecular Biology in a new era where we can visualize, analyze and interpret the structures and functions of all proteins solely from their primary sequences. We performed AF2 structure predictions for various protein systems,
Haoyang Guo +12 more
semanticscholar +1 more source
Backbone dynamics of complement control protein (CCP) modules reveals mobility in binding surfaces [PDF]
, 2004 The regulators of complement activation (RCA) are critical to health and disease because their role is to ensure that a complement-mediated immune response to infection is proportionate and targeted.
Krystyna Bromek +19 more
core +1 more source
An NMR View of Protein Dynamics in Health and Disease.
Annual Review of Biophysics, 2019 Biological molecules are often highly dynamic, and this flexibility can be critical for function. The large range of sampled timescales and the fact that many of the conformers that are continually explored are only transiently formed and sparsely ...
A. Sekhar, L. Kay
semanticscholar +1 more source
Protein Dynamics by Neutron Scattering: The Protein Dynamical Transition [PDF]
Biophysical Journal, 2012 Despite recent extensive efforts, the nature of the dynamics of biological macromolecules still remains unclear. in particular, contradicting models have been proposed for explaining the temperature behavior of the mean square displacement, MSD, and of the characteristic system time, τ.
Benedetto, Antonio +2 more
openaire +1 more source
Discrete analyses of protein dynamics
Journal of Biomolecular Structure and Dynamics, 2019 Protein structures are highly dynamic macromolecules. This dynamics is often analysed through experimental and/or computational methods only for an isolated or a limited number of proteins.
T. Narwani +10 more
semanticscholar +1 more source
Dynamics in unfolded polypeptide chains as model for elementary steps in protein folding [PDF]
, 2004 This thesis deals with the dynamics of unfolded polypeptide chains as model for the earliest steps in protein folding. Starting from an ensemble of unfolded conformations a folding polypeptide chain has to form specific backbone and side-chain ...
Krieger, Florian
core +1 more source