Results 21 to 30 of about 16,988,925 (342)
Developing a peptide to disrupt cohesin head domain interactions
iScience, 2023 Summary: Cohesin mediates the 3-D structure of chromatin and is involved in maintaining genome stability and function. The cohesin core comprises Smc1 and Smc3, elongated-shaped proteins that dimerize through globular domains at their edges, called head ...
Maria Elias +9 more
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Prediction of disordered regions in proteins with recurrent Neural Networks and protein dynamics
bioRxiv, 2020 The role of intrinsically disordered protein regions (IDRs) in cellular processes has become increasingly evident over the last years. These IDRs continue to challenge structural biology experiments because they lack a well-defined conformation, and ...
Gabriele Orlando +4 more
semanticscholar +1 more source
The antidepressant drug vilazodone is an allosteric inhibitor of the serotonin transporter
Nature Communications, 2021 Vilazodone (VLZ) is a drug for the treatment of major depressive disorders that targets the serotonin transporter (SERT). Here, the authors combine pharmacology measurements and cryo-EM structural analysis to characterize VLZ binding to SERT and observe ...
Per Plenge +8 more
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A Simple and Scalable Strategy for Analysis of Endogenous Protein Dynamics
Scientific Reports, 2020 The ability to analyze protein function in a native context is central to understanding cellular physiology. This study explores whether tagging endogenous proteins with a reporter is a scalable strategy for generating cell models that accurately ...
Marie K. Schwinn +4 more
semanticscholar +1 more source
FEBS Letters, 1994 Modern NMR has revitalized the study of protein dynamics. Multidimensional spectra and the heteronuclear spectroscopy allow a substantial gain in resolution. Dynamics can be analyzed at individual sites and data on segmental and sequence‐dependent flexibility are accumulating.
Jardetzky, Oleg +1 more
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A dynamical view of protein-protein complexes: Studies by molecular dynamics simulations
Frontiers in Molecular Biosciences, 2022 Protein-protein interactions are at the basis of many protein functions, and the knowledge of 3D structures of protein-protein complexes provides structural, mechanical and dynamical pieces of information essential to understand these functions. Protein-protein interfaces can be seen as stable, organized regions where residues from different partners ...
Martin, Juliette, Frezza, Elisa
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Molecular dynamics as an approach to study prion protein misfolding and the effect of pathogenic mutations [PDF]
, 2011 Computer simulation of protein dynamics offers unique high-resolution information that complements experiment. Using experimentally derived structures of the natively folded prion protein (PrP), physically realistic dynamics and conformational changes ...
Valerie Daggett +3 more
core +1 more source
Glassy dynamics of protein folding [PDF]
Physical Review E, 2000 A coarse grained model of a random polypeptide chain, with only discrete torsional degrees of freedom and Hookean springs connecting pairs of hydrophobic residues is shown to display stretched exponential relaxation under Metropolis dynamics at low temperatures with the exponent $β\simeq 1/4$, in agreement with the best experimental results.
Tuzel, E, Erzan, A
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F1000Research, 2019 The Sec translocon provides a polypeptide-conducting channel, which is insulated from the hydrophobic lipidic environment of the membrane, for translocation of hydrophilic passenger polypeptides.
Koreaki Ito +2 more
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A Dynamical Approach to Protein Folding [PDF]
Journal of Biological Physics, 2001 In this paper we show that a dynamical description of the protein folding process provides an effective representation of equilibrium properties and it allows for a direct investigation of the mechanisms ruling the approach towards the native configuration.
A. TORCINI, LIVI, ROBERTO, A. POLITI
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