Results 31 to 40 of about 16,988,925 (342)
Universality in protein residue networks [PDF]
, 2010 Residue networks representing 595 nonhomologous proteins are studied. These networks exhibit universal topological characteristics as they belong to the topological class of modular networks formed by several highly interconnected clusters separated by ...
Estrada, Ernesto +1 more
core +4 more sources
Lasso-grafting of macrocyclic peptide pharmacophores yields multi-functional proteins
Nature Communications, 2021 RaPID (Random non-standard Peptides Integrated Discovery) enables discovery of small macrocyclic peptides binding desired targets. Here, the authors propose lasso-grafting: the RaPID-derived peptides are implanted onto diverse proteins and maintain both ...
Emiko Mihara +12 more
doaj +1 more source
Are Protein Shape-Encoded Lowest-Frequency Motions a Key Phenotype Selected by Evolution?
Applied Sciences, 2023 At the very deepest molecular level, the mechanisms of life depend on the operation of proteins, the so-called “workhorses” of the cell. Proteins are nanoscale machines that transform energy into useful cellular work, such as ion or nutrient transport ...
Laura Orellana
doaj +1 more source
ATLAS: protein flexibility description from atomistic molecular dynamics simulations
Nucleic Acids Research, 2023 Dynamical behaviour is one of the most crucial protein characteristics. Despite the advances in the field of protein structure resolution and prediction, analysis and prediction of protein dynamic properties remains a major challenge, mostly due to the ...
Yann Vander Meersche +4 more
semanticscholar +1 more source
COMPARISONS OF PROTEIN FAMILY DYNAMICS [PDF]
Biocomputing 2008, 2007 Similarities between different protein structures have led to the identification of protein families based upon some measure of structural similarity. Using these similarities one can classify proteins into structural families and higher-order groupings from which inferred function can be transferred.
A. J. Radar, Joshua T. Harrell
openaire +3 more sources
Protein Folding and Macromolecular Dynamics: Fundamental Limits of Length and Time Scales [PDF]
, 2012 In this thesis, physics-based models of protein folding at the secondary and tertiary level are developed to resolve long-standing issues of protein folding kinetics.
Lin, Milo Miaoyu
core +1 more source
Computational approaches for drug design at the Protein-Protein interface [PDF]
, 2010 The ability to design drugs that disrupt formation of protein-protein interfaces is of particular interest to the pharmaceutical industry due to its promise for opening an entire new range of drug targets, many of which have already been well ...
Fuller, Jonathan Christopher
core +6 more sources
Studying protein-protein interactions using peptide arrays [PDF]
, 2010 Screening of arrays and libraries of compounds is well-established as a high-throughput method for detecting and analyzing interactions in both biological and chemical systems. Arrays and libraries can be composed from various types of molecules, ranging
Rito, T. +7 more
core +1 more source
Release factor-dependent ribosome rescue by BrfA in the Gram-positive bacterium Bacillus subtilis
Nature Communications, 2019 In bacteria, the conserved trans-translation system serves as the primary pathway of ribosome rescue, but many species can also use alternative rescue pathways. Here the authors report that in B. subtilis, the rescue factor BrfA binds to non-stop stalled
Naomi Shimokawa-Chiba +6 more
doaj +1 more source
Dynamics of protein hydration water [PDF]
Physical Review E, 2015 We present the frequency- and temperature-dependent dielectric properties of lysozyme solutions in a broad concentration regime, measured at subzero temperatures and compare the results with measurements above the freezing point of water and on hydrated lysozyme powder.
Wolf, M. +4 more
openaire +4 more sources