Dynamics of protein hydration water [PDF]
Physical Review E, 2015 We present the frequency- and temperature-dependent dielectric properties of lysozyme solutions in a broad concentration regime, measured at subzero temperatures and compare the results with measurements above the freezing point of water and on hydrated lysozyme powder.
Wolf, M. +4 more
openaire +4 more sources
Substrate-induced conformational dynamics of the dopamine transporter
Nature Communications, 2019 The dopamine transporter is responsible for termination of neurotransmission through Na+-driven reuptake of neurotransmitter from the extracellular space. Here authors use hydrogen-deuterium exchange mass spectrometry to monitor Na+- and dopamine-induced
Anne Kathrine Nielsen +6 more
doaj +1 more source
gbabbitt/DROIDS-1.0---free-software-project-for-comparative-protein-dynamics: DROIDS 1.20 - software for comparative protein dynamics [PDF]
, 2017 <p>In this final pre-publication version of our code, we have simplified our analysis. We are finding that comparative analysis of atom fluctuation indicates global destabilization of proteins involved in several major human congenital diseases ...
gbabbitt
core +1 more source
Protein Dynamics by Neutron Scattering: The Protein Dynamical Transition [PDF]
Biophysical Journal, 2012 Despite recent extensive efforts, the nature of the dynamics of biological macromolecules still remains unclear. in particular, contradicting models have been proposed for explaining the temperature behavior of the mean square displacement, MSD, and of the characteristic system time, τ.
Benedetto, Antonio +2 more
openaire +1 more source
Protein-induced changes in DNA structure and dynamics observed with noncovalent site-directed spin-labeling and PELDOR [PDF]
, 2012 Site-directed spin labeling and pulsed electron–electron double resonance (PELDOR or DEER) have previously been applied successfully to study the structure and dynamics of nucleic acids. Spin labeling nucleic acids at specific sites requires the covalent
Reginsson, Gunnar Widtfeldt +5 more
core +1 more source
Conformational dynamics of the human serotonin transporter during substrate and drug binding
Nature Communications, 2019 The serotonin transporter (SERT) is responsible for re-uptake of serotonin into the presynaptic neuron and plays a key role in synaptic transmission. Here, the authors use hydrogen-deuterium exchange mass spectrometry to probe the conformational dynamics
Ingvar R. Möller +6 more
doaj +1 more source
Computational Approaches for Protein Dynamics and Function [PDF]
Proteins are fascinating structures that operate at the nanoscale in a complex environment and are involved in an astonishingly wide variety of functions, from ion transport to enzymatic catalysis, metabolism, neurotransmission, and many more functions ...
core +1 more source
Prediction of Functional Sites in SCOP Domains using Dynamics Perturbation Analysis [PDF]
, 2008 Dynamics perturbation analysis (DPA) finds regions in a protein structure where proteins are "ticklish", i.e., where interactions cause a large change in protein dynamics.
Michael E. Wall +2 more
core +2 more sources
Universality in protein residue networks [PDF]
, 2010 Residue networks representing 595 nonhomologous proteins are studied. These networks exhibit universal topological characteristics as they belong to the topological class of modular networks formed by several highly interconnected clusters separated by ...
Estrada, Ernesto +3 more
core +1 more source
Allosteric rescue of catalytically impaired ATP phosphoribosyltransferase variants links protein dynamics to active-site electrostatic preorganisation [PDF]
, 2022 ATP phosphoribosyltransferase catalyses the first step of histidine biosynthesis and is controlled via a complex allosteric mechanism where the regulatory protein HisZ enhances catalysis by the catalytic protein HisGS while mediating allosteric ...
Gemma, Fisher +6 more
core +1 more source