Results 11 to 20 of about 16,988,925 (342)
Dynamics and thermodynamics of protein-ligand interactions [PDF]
, 2012 Complex networks of protein-ligand interactions underpin cellular function and communication. Disease can arise from disruption of these networks through the alteration of protein-ligand interaction affinities, for example by protein mutation or ligand ...
Malham, Richard William
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Functional Dynamics of Proteins [PDF]
Computational and Mathematical Methods in Medicine, 2012 X-ray crystallography captures protein conformational states that are stable enough to be captured. These observable states are simply part of the functional event in the context of protein dynamics. Life at the molecular level has a vibrant nature at physiological temperature, governed by physics laws. Molecular dynamics (MDs) simulations have been
Lee-Wei Yang +4 more
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Cells, 2022 The dopamine transporter (DAT) is a member of the neurotransmitter:sodium symporter (NSS) family, mediating the sodium-driven reuptake of dopamine from the extracellular space thereby terminating dopaminergic neurotransmission.
Ciara Frances Pugh +3 more
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Cells, 2020 Centrioles are microtubule-based cellular structures present in most human cells that build centrosomes and cilia. Proliferating cells have only two centrosomes and this number is stringently maintained through the temporally and spatially controlled ...
Catherine Sullenberger +3 more
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Modern Tools for Rapid Diagnostics of Antimicrobial Resistance
Frontiers in Cellular and Infection Microbiology, 2020 Fast, robust, and affordable antimicrobial susceptibility testing (AST) is required, as roughly 50% of antibiotic treatments are started with wrong antibiotics and without a proper diagnosis of the pathogen. Validated growth-based AST according to EUCAST
Antti Vasala +3 more
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A protein quality control pathway at the mitochondrial outer membrane
eLife, 2020 Maintaining the essential functions of mitochondria requires mechanisms to recognize and remove misfolded proteins. However, quality control (QC) pathways for misfolded mitochondrial proteins remain poorly defined.
Meredith B Metzger +4 more
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Reduced efficacy of a Src kinase inhibitor in crowded protein solution
Nature Communications, 2021 The intracellular compartment is a crowded environment. Here, the authors use molecular dynamics (MD) simulations to assess inhibitor binding to c-Src kinase and show how ligand binding pathways differ in crowded and dilute protein solutions ...
Kento Kasahara +10 more
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The dopamine transporter antiports potassium to increase the uptake of dopamine
Nature Communications, 2022 The dopamine transporter, DAT, controls dopamine signaling by facilitating its reuptake using the Na+ gradient as driving force. Here, the authors uncover that an antiport of K+ ions also contributes to setting the rate of DAT-mediated dopamine clearance.
Solveig G. Schmidt +9 more
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Dynamic Proteins in Bacteria [PDF]
Developmental Cell, 2001 The MinCDE system regulates the position of the division plane in rod-shaped bacteria. New results from Escherichia coli provide insight into how this operates by showing that MinE stimulates the ATPase activity of MinD.
Autret S, Errington J
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