Results 11 to 20 of about 827,705 (313)
Dynamic Proteins in Bacteria [PDF]
Developmental Cell, 2001 The MinCDE system regulates the position of the division plane in rod-shaped bacteria. New results from Escherichia coli provide insight into how this operates by showing that MinE stimulates the ATPase activity of MinD.
Autret S, Errington J
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The antidepressant drug vilazodone is an allosteric inhibitor of the serotonin transporter
Nature Communications, 2021 Vilazodone (VLZ) is a drug for the treatment of major depressive disorders that targets the serotonin transporter (SERT). Here, the authors combine pharmacology measurements and cryo-EM structural analysis to characterize VLZ binding to SERT and observe ...
Per Plenge +8 more
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FEBS Letters, 1994 Modern NMR has revitalized the study of protein dynamics. Multidimensional spectra and the heteronuclear spectroscopy allow a substantial gain in resolution. Dynamics can be analyzed at individual sites and data on segmental and sequence‐dependent flexibility are accumulating.
Jardetzky, Oleg +1 more
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A dynamical view of protein-protein complexes: Studies by molecular dynamics simulations
Frontiers in Molecular Biosciences, 2022 Protein-protein interactions are at the basis of many protein functions, and the knowledge of 3D structures of protein-protein complexes provides structural, mechanical and dynamical pieces of information essential to understand these functions. Protein-protein interfaces can be seen as stable, organized regions where residues from different partners ...
Martin, Juliette, Frezza, Elisa
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Molecular dynamics as an approach to study prion protein misfolding and the effect of pathogenic mutations [PDF]
, 2011 Computer simulation of protein dynamics offers unique high-resolution information that complements experiment. Using experimentally derived structures of the natively folded prion protein (PrP), physically realistic dynamics and conformational changes ...
Valerie Daggett +3 more
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Glassy dynamics of protein folding [PDF]
Physical Review E, 2000 A coarse grained model of a random polypeptide chain, with only discrete torsional degrees of freedom and Hookean springs connecting pairs of hydrophobic residues is shown to display stretched exponential relaxation under Metropolis dynamics at low temperatures with the exponent $β\simeq 1/4$, in agreement with the best experimental results.
Tuzel, E, Erzan, A
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Protein Folding and Macromolecular Dynamics: Fundamental Limits of Length and Time Scales [PDF]
, 2012 In this thesis, physics-based models of protein folding at the secondary and tertiary level are developed to resolve long-standing issues of protein folding kinetics.
Lin, Milo Miaoyu
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F1000Research, 2019 The Sec translocon provides a polypeptide-conducting channel, which is insulated from the hydrophobic lipidic environment of the membrane, for translocation of hydrophilic passenger polypeptides.
Koreaki Ito +2 more
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Molecular dynamics decomposition of temperature-dependent elastic neutron scattering by a protein solution [PDF]
, 2003 Molecular dynamics simulations are performed of bovine pancreatic trypsin inhibitor in a cryosolution over a range of temperatures from 80 to 300 K and the origins identified of elastic dynamic neutron scattering from the solution. The elastic scattering
Smith, Jeremy C. +7 more
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Backbone dynamics of complement control protein (CCP) modules reveals mobility in binding surfaces [PDF]
, 2004 The regulators of complement activation (RCA) are critical to health and disease because their role is to ensure that a complement-mediated immune response to infection is proportionate and targeted.
Krystyna Bromek +19 more
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