Results 81 to 90 of about 7,816,364 (345)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Development profile of hemolymph soluble proteins during the larval and pupal stages in Aldrichina grahami

浙江大学学报. 农业与生命科学版, 2004
The development profile of soluble hemolymph proteins was analyzed by the gradient SDS-polyacrylamide gel (5%-20%) electrophoresis during the larval and pupal stages of Aldrichina grahami (Aldrich) which was kept at 24℃.
ZHU Guang-hui, YE Gong-yin, HU Cui
doaj   +1 more source

Cloning of the C-terminal cytoplasmic fragment of the tar protein and effects of the fragment on chemotaxis of Escherichia coli [PDF]

, 1988
A gene encoding only the C-terminal portion of the receptor-transducer protein Tar of Escherichia coli was constructed. The gene product was detected and localized in the cytoplasmic fraction of the cell by immunoblotting with anti-Tar antibodies.
Mutoh, Norihiro, Oosawa, Kenji, Simon, M. I.   +2 more
core   +1 more source

Seed protein electrophoresis of some members of the family fabaceae

, 2014
Seed storage protein profiles of 10 members of the family Fabaceae were assessed using sodium dodecyl sulphate polyacrylamide gel electrophoresis (SDS-PAGE).
G. Alege, N. Abu, C. E. Sunday
semanticscholar   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

METODOLOGIA DE CREARE A PAȘAPOARTELOR ELECTROFORETICE ALE HIBRIZILOR DE PORUMB ȘI FORMELE LOR PARENTALE LA NIVELUL MOLECULELOR PROTEICE

Agricultural Science
The development and use of rapid methods to control the genetic purity of seed material contributes to ensuring the quality of hybrid maize seeds.
Grigorii BATÎRU, Galina COMAROVA, Arcadii ADAMCIUC, Eugen ROTARI, Serghei BOUNEGRU, Dumitru COJOCARI, Alexandr ROTARI   +6 more
doaj   +1 more source

Monoclonal gammopathy missed by capillary zone electrophoresis [PDF]

, 2017
Background: Serum protein electrophoresis is used as a screening test for monoclonal gammopathies. Here, we present a case of a high-concentration monoclonal immunoglobulin (M-protein) that was missed by serum protein electrophoresis on a Capillarys 2 ...
Egger, Florence, Kaelin-Lang, Alain, Nuoffer, Jean-Marc, Schild, Christof   +3 more
core  

Chromosomal control of non-gliadin proteins from the 70% ethanol extract of wheat endosperm

, 1975
The non-gliadin fraction of the 70% ethanol extracts of compensated nulli-tetrasomics and ditelosomics of Triticum aestivum cv. Chinese Spring has been analyzed by combined electrofocusing and electrophoresis.
A. Bozzini, B. L. Johnson, B. L. Johnson, C. Aragoncillo, C. W. Wrigley, C. W. Wrigley, F. Garcia-Olmedo, F. García-Olmedo, J. D. Eastin, K. A. Siddiqui, K. Noda, K. W. Shepherd, M. A. Rodriguez Loperena, Pilar Carbonero, R. A. Orth, R. Riley, R. Solari, R. Solari, W. J. R. Boyd, W. J. R. Boyd   +19 more
core   +1 more source

The role of serum protein electrophoresis in the detection of multiple myeloma: an experience of a corporate hospital.

Journal of clinical and diagnostic research : JCDR, 2012
BACKGROUND Multiple Myeloma (M.M) is a neoplasm of B cell lineage characterized by excessive proliferation of abnormal plasma cells, secreting abnormal immunoglobulin causing monoclonal gammopathy which can be detected by the presence of M protein in ...
Sunita Tripathy
semanticscholar   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source