Results 101 to 110 of about 677,670 (306)

Protein engineering of enzymes involved in lipid modification

, 2018
Isabel Oroz‐Guinea, Katja Zorn, Henrike Brundiek   +2 more
openalex   +2 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Comparative analysis of neutralization assays performed using live SARS-CoV-2 virus and pseudovirus to assess immunogenicity of a bivalent SARS-CoV-2 protein vaccine in humans

Frontiers in Immunology
ObjectivesThe rapid emergence of SARS-CoV-2 prompted accelerated vaccine development, with neutralization assays serving as essential tools to evaluate vaccine-induced immune responses.MethodsA post-hoc analysis of a Phase I/II trial evaluated the ...
Cuige Gao, Jiang Yi, Adam Baidoo, Dongfang Liu, Jing Li, Dongyang Li, Jian Li, Qiang Zhou, Liangzhi Xie, Liangzhi Xie, Liangzhi Xie   +10 more
doaj   +1 more source

Engineering of TIMP‐3 as a LAP‐fusion protein for targeting to sites of inflammation [PDF]

, 2018
Ben M. Alberts, Sandra Sacre, Peter G. Bush, L. Mullen   +3 more
openalex   +1 more source

Modular DNA origami compartments for the engineering of a protein unfolding and degradation pathway [PDF]

, 2023
Barbara Saccà, Jing Huang, Andreas Jaekel, Johannes van den Boom, David Podlesainski, Manar Elnagar, Amelie Heuer‐Jungemann, Markus Kaiser, Hemmo Meyer   +8 more
openalex   +1 more source

Protein Engineering [PDF]

FEBS Letters, 2013
openaire   +2 more sources

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Protein engineering

Current Opinion in Biotechnology, 1991
openaire   +3 more sources

Engineering protein nanocages as carriers for biomedical applications [PDF]

, 2017
Sathyamoorthy Bhaskar, Sierin Lim
openalex   +1 more source