Results 111 to 120 of about 677,670 (306)

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Protein engineering

Current Opinion in Biotechnology, 1996
, de Vos AM, , Plückthun
openaire   +3 more sources

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Engineering RNA‐binding proteins for biology [PDF]

, 2013
Yu Chen, Gabriele Varani
openalex   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Enhancing Paenibacillus sp. Cold-Active Acetyl Xylan Esterase Activity through Semi-Rational Protein Engineering [PDF]

Keunho Ji, Sondavid Nandanwar, So Yeon Jeon, Gyu Ri Yang, Lixiao Liu, Hyun‐Myung Oh, Hak Jun Kim   +6 more
openalex   +1 more source

The Generation and Exploitation of Protein Mutability Landscapes for Enzyme Engineering [PDF]

, 2016
Jan‐Ytzen van der Meer, Lieuwe Biewenga, Gerrit J. Poelarends   +2 more
openalex   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Pharmacological profiling of Camellia sinensis and Rosa damascena extracts based gel formulation: highlighting its in vitro efficacy in diabetes management

Discover Applied Sciences
Camellia sinensis and Rosa damascena are a rich source of antioxidants with abundant catechins acting as a radical scavenger by preventing cell damage caused by oxidants.
Sujatha Elangovan, Prasanna Srinivasan Ramalingam, Kuriti Sowmya, Sivakumar Arumugam   +3 more
doaj   +1 more source

Arming Technology in Yeast—Novel Strategy for Whole-cell Biocatalyst and Protein Engineering [PDF]

, 2013
Kouichi Kuroda, Mitsuyoshi Ueda
openalex   +1 more source