Results 191 to 200 of about 8,269,032 (242)

High-Temperature Tolerance Protein Engineering through Deep Evolution. [PDF]

Biodes Res
Chu H, Tian Z, Hu L, Zhang H, Chang H, Bai J, Liu D, Lu L, Cheng J, Jiang H.   +9 more
europepmc   +1 more source

Structural basis of nearest-neighbor cooperativity in the ring-shaped gene regulatory protein TRAP from protein engineering and cryo-EM. [PDF]

Proc Natl Acad Sci U S A
Li W, Yang H, Stachowski K, Norris AS, Lichtenthal K, Kelly S, Gollnick P, Wysocki VH, Foster MP.   +8 more
europepmc   +1 more source

Zero-shot prediction of mutation effects with multimodal deep representation learning guides protein engineering. [PDF]

Cell Res
Cheng P, Mao C, Tang J, Yang S, Cheng Y, Wang W, Gu Q, Han W, Chen H, Li S, Chen Y, Zhou J, Li W, Pan A, Zhao S, Huang X, Zhu S, Zhang J, Shu W, Wang S.   +19 more
europepmc   +1 more source

Protein engineering of transaminase facilitating enzyme cascade reaction for the biosynthesis of azasugars. [PDF]

iScience
Zhu Y, Chen P, Dong Q, Li Q, Liu D, Liu T, Liu W, Sun Y.   +7 more
europepmc   +1 more source

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Protein engineering

Current Opinion in Biotechnology, 1992
Ten years of protein engineering have seen the synthesis of novel therapeutic agents and the analysis of the structure, activity, specificity, stability and folding pathways of proteins. It is hoped that protein engineering will eventually lead to the design of novel catalytic sites on either novel or existing proteins.
R B, Freedman, R, Wetzel
  +8 more sources

Insertions and Deletions (Indels): A Missing Piece of the Protein Engineering Jigsaw.

Biochemistry, 2022
Over the years, protein engineers have studied nature and borrowed its tricks to accelerate protein evolution in the test tube. While there have been considerable advances, our ability to generate new proteins in the laboratory is seemingly limited.
C. Miton, N. Tokuriki
semanticscholar   +1 more source

PyPEF - An Integrated Framework for Data-Driven Protein Engineering

Journal of Chemical Information and Modeling, 2021
Data-driven strategies are gaining increased attention in protein engineering due to recent advances in access to large experimental databanks of proteins, next-generation sequencing (NGS), high-throughput screening (HTS) methods, and the development of ...
Niklas E. Siedhoff, Alexander-Maurice Illig, U. Schwaneberg, M. Davari   +3 more
semanticscholar   +1 more source

Protein engineering of ribonucleases

Biochimie, 1998
Natural bovine seminal RNase possesses a potent antitumor action. We have mutagenized monomeric bovine pancreatic RNase A, devoid of any cytotoxic action, to insert residues present at corresponding positions in the subunit of dimeric, antitumor, seminal RNase.
CAFARO, VALERIA, BRACALE, AURORA, Formiggini F., NOTOMISTA, EUGENIO, D'ALESSIO, GIUSEPPE, DI DONATO, ALBERTO   +5 more
openaire   +7 more sources

Protein engineering for thermostability [PDF]

Trends in Biotechnology, 1990
Studies with small, monomeric proteins indicate that, to some extent, the effects of amino acid substitutions can be predicted. However, conformational and other changes may complicate the prediction. Site-directed mutagenesis is leading both to a better understanding of protein stability and to the production of more stable proteins.
Yoshiaki Nosoh, Takeshi Sekiguchi
openaire   +2 more sources