Results 201 to 210 of about 708,742 (265)

Rational Protein Engineering to Enhance MHC-Independent T-cell Receptors. [PDF]

Cancer Discov
Chang JF, Landmann JH, Chang TC, Selli ME, Tenzin Y, Warrington JM, Ritchey J, Hsu YS, Slade M, Gupta DK, DiPersio JF, Holehouse AS, Singh N.   +12 more
europepmc   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Critical Assessment of Protein Engineering (CAPE): A Student Challenge on the Cloud. [PDF]

ACS Synth Biol
Fu L, Gao Y, Chen Y, Wang Y, Fang X, Tian S, Dong H, Zhang Y, Chen Z, Wang Z, Hu S, Yi X, Si T.   +12 more
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Identification and Protein Engineering of Galactosidases for the Conversion of Blood Type B to Blood Type O. [PDF]

Chembiochem
Möller C, Terholsen H, Schmöker O, Lê TLA, Wesche J, Schmiade P, Eppendorfer E, Rimkus N, Girbardt B, Böttcher D, Palm GJ, Hoppen J, Lammers M, Greinacher A, Aurich K, Bornscheuer UT.   +15 more
europepmc   +1 more source

Computational epitope profiling and AI-driven protein engineering enable rational design of multi-epitope vaccines against <i>Mycobacterium tuberculosis</i>. [PDF]

Comput Struct Biotechnol J
Li X, Tao X, Zhong M, Wang Y, Xue H, Andongma BT, Chou SH, Wei H, He J, Yang H.   +9 more
europepmc   +1 more source

Structural studies of the IFNλ4 receptor complex using cryoEM enabled by protein engineering. [PDF]

Nat Commun
Grubbe WS, Zhang B, Kauffman A, Byléhn F, Padoł K, Jung HG, Park SB, Priest JM, Özkan E, de Pablo JJ, Liang TJ, Zhao M, Mendoza JL.   +12 more
europepmc   +1 more source

Biosynthesis of Halogenated Tryptophans for Protein Engineering Using Genetic Code Expansion. [PDF]

Chembiochem
Guo Y, Cheng L, Hu Y, Zhang M, Liu R, Wang Y, Jiang S, Xiao H.   +7 more
europepmc   +1 more source

Semirational Protein Engineering Yields Archaerhodopsin-3-Based Fluorescent Genetically Encoded Voltage Indicators with Enhanced Brightness and Red Shifted Absorption Bands. [PDF]

Chem Bio Eng
Nikolaev DM, Metelkina EM, Domskii NA, Osadchy IR, Mereshchenko AS, Bondarev SA, Zhouravleva GA, Shtyrov AA, Panov MS, Ryazantsev MN.   +9 more
europepmc   +1 more source

Chemical Protein Engineering: Backbone Cyclization Rescues Folding of a 183-Residue Truncated Domain of Malaria Parasite Protein PfAMA1. [PDF]

Chemistry
Mannuthodikayil J, Malik V, Kar A, Singh S, Mandal K.   +4 more
europepmc   +1 more source