Results 201 to 210 of about 1,300,384 (288)

Protein modelling for enzyme engineering [PDF]

, 2017
Guallar, Victor, Santiago, Gerard
core  

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Correction: Phosphoglycerate dehydrogenase promotes pancreatic cancer development by interacting with eIF4A1 and eIF4E

Journal of Experimental & Clinical Cancer Research
Xuhui Ma, Boya Li, Jie Liu, Yan Fu, Yongzhang Luo   +4 more
doaj   +1 more source

Resolution of physics and deep learning-based protein engineering filters: A case study with a lipase for industrial substrate hydrolysis. [PDF]

PLoS One
Gardiner S, Dollinger P, Kovacic F, Pietruszka J, Ess DH, Jaeger KE, Schröder GF, Della Corte D.   +7 more
europepmc   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Protein engineering to overcome limitations of key cytokines in cancer immunotherapy: current approaches and future perspectives. [PDF]

Immunooncol Technol
Salazar U, Cioffi P, Taskoparan B, Moraga I, Mitra S, Vom Berg J.   +5 more
europepmc   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Optimizing longifolene production in Yarrowia lipolytica via metabolic and protein engineering. [PDF]

Synth Syst Biotechnol
Yao YT, Zhang X, Wang CY, Zhang YH, Li DW, Yang WD, Li HY, Zou LG.   +7 more
europepmc   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Protein engineering using variational free energy approximation. [PDF]

Nat Commun
Lobzaev E, Herrera MA, Kasprzyk M, Stracquadanio G.   +3 more
europepmc   +1 more source