Results 221 to 230 of about 9,762,259 (268)

Semi-supervised prediction of protein fitness for data-driven protein engineering. [PDF]

J Cheminform
Olivares-Gil A, Barbero-Aparicio JA, Rodríguez JJ, Díez-Pastor JF, García-Osorio C, Davari MD.   +5 more
europepmc   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

PRIME, a temperature-guided language model revolutionizes protein engineering. [PDF]

Acta Pharm Sin B
Yu Y, Wang Q, Zou Y.
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Protein engineering strategies to optimise recombinant product synthesis and accumulation in Nicotiana benthamiana. [PDF]

Plant Biotechnol J
Harding MD, Sainsbury F.
europepmc   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Results of the Protein Engineering Tournament: An Open Science Benchmark for Protein Modeling and Design. [PDF]

Proteins
Armer C, Kane H, Cortade DL, Redestig H, Estell DA, Yusuf A, Rollins N, Spinner A, Marks D, Brunette TJ, Kelly PJ, DeBenedictis E.   +11 more
europepmc   +1 more source

Enhanced rational protein engineering to reduce viscosity in high-concentration IgG1 antibody solutions. [PDF]

MAbs
Lefevre TJ, Caldwell JG, Gallegos A, Du Q, Houston E, Kaplan G, Esfandiary R.   +6 more
europepmc   +1 more source

An update on thermostable keratinases for protein engineering against feather pollutants. [PDF]

Appl Microbiol Biotechnol
J L BJ, Dhanasingh I.
europepmc   +1 more source

Protein engineering using variational free energy approximation. [PDF]

Nat Commun
Lobzaev E, Herrera MA, Kasprzyk M, Stracquadanio G.   +3 more
europepmc   +1 more source