Results 221 to 230 of about 708,742 (265)
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Engineered Proteins for Bioelectrochemistry
Annual Review of Analytical Chemistry, 2014It is only in the past two decades that excellent protein engineering tools have begun to meet parallel advances in materials chemistry, nanofabrication, and electronics. This is revealing scenarios from which synthetic enzymes can emerge, which were previously impossible, as well as interfaces with novel electrode materials. That means the control of
Muhammad Safwan, Akram +2 more
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Protein Engineering, a Robust Tool to Engineer Novel Functions in Protein
Protein & Peptide Letters, 2023Abstract: Designing effective diagnostics, biotherapeutics, and biocatalysts are a few interesting potential outcomes of protein engineering. Despite being just a few decades old, the discipline of de novo protein designing has provided a foundation for remarkable outcomes in the pharmaceuticals and enzyme industries.
, Nancy +4 more
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Protein engineering of lantibiotics
Antonie van Leeuwenhoek, 1996Whereas protein engineering of enzymes and structural proteins nowadays is an established research tool for studying structure-function relationships of polypeptides and for improving their properties, the engineering of posttranslationally modified peptides, such as the lantibiotics, is just coming of age.
Kuipers, O.P. +17 more
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Protein engineering for thermostability
Trends in Biotechnology, 1990Studies with small, monomeric proteins indicate that, to some extent, the effects of amino acid substitutions can be predicted. However, conformational and other changes may complicate the prediction. Site-directed mutagenesis is leading both to a better understanding of protein stability and to the production of more stable proteins.
Y, Nosoh, T, Sekiguchi
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Engineering therapeutic proteins
Current Opinion in Structural Biology, 2000Many early drug candidates derived from biotechnology failed in clinical trials because of their low affinity/specificity, short half-lives or immunogenicity. Protein engineering techniques have been applied to circumvent some of the problems that hindered these earlier trials, resulting in clinical benefits from a range of engineered antibodies and ...
J, McCafferty, D R, Glover
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Current Opinion in Biotechnology, 1995
Much of the research on integral membrane proteins mirrors that on soluble proteins; however, membrane protein engineering also has its own ends and means, many of which take advantage of the peculiar situation of membrane proteins, whose chains are distributed between one lipidic and two aqueous phases. Extramembrane loops have been shortened, cut, or
J L, Popot, M, Saraste
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Much of the research on integral membrane proteins mirrors that on soluble proteins; however, membrane protein engineering also has its own ends and means, many of which take advantage of the peculiar situation of membrane proteins, whose chains are distributed between one lipidic and two aqueous phases. Extramembrane loops have been shortened, cut, or
J L, Popot, M, Saraste
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Physiology, 2003
Proteins that belong to the ATP-binding cassette superfamily span from bacteria to humans and comprise one of the largest protein families. These proteins are characterized by the presence of two nucleotide-binding domains, and recent studies suggest that association and dissociation of these domains is a common basic molecular mechanism of operation ...
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Proteins that belong to the ATP-binding cassette superfamily span from bacteria to humans and comprise one of the largest protein families. These proteins are characterized by the presence of two nucleotide-binding domains, and recent studies suggest that association and dissociation of these domains is a common basic molecular mechanism of operation ...
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Protein engineering of amylases
Biochemical Society Transactions, 1992Introduction Amylases of varying specificity catalyse the degradation of starch and related oligoand poly-saccharides 111. These enzymes occur widely in plants, animals and micro-organisms and many, in particular those of bacterial or fungal origin, are used in the starch industry.
B, Svensson, M, Søgaard
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Protein engineering of cellulases
Current Opinion in Biotechnology, 2014This review covers the topic of protein engineering of cellulases, mostly after 2009. Two major trends that are identified in this work are: first, the increased importance of results from computational protein engineering to drive ideas in the field, as experimental ideas and results often are still scarce, and, second, the further development of ...
Bommarius, AS Bommarius, Andreas S. +4 more
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Protein engineering of subtilisin
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 2000The serine protease subtilisin is an important industrial enzyme as well as a model for understanding the enormous rate enhancements affected by enzymes. For these reasons along with the timely cloning of the gene, ease of expression and purification and availability of atomic resolution structures, subtilisin became a model system for protein ...
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