Results 231 to 240 of about 9,762,259 (268)

Optimizing longifolene production in Yarrowia lipolytica via metabolic and protein engineering. [PDF]

Synth Syst Biotechnol
Yao YT, Zhang X, Wang CY, Zhang YH, Li DW, Yang WD, Li HY, Zou LG.   +7 more
europepmc   +1 more source

Protein engineering to overcome limitations of key cytokines in cancer immunotherapy: current approaches and future perspectives. [PDF]

Immunooncol Technol
Salazar U, Cioffi P, Taskoparan B, Moraga I, Mitra S, Vom Berg J.   +5 more
europepmc   +1 more source

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Thermal stability enhancement: Fundamental concepts of protein engineering strategies to manipulate the flexible structure.

International Journal of Biological Macromolecules, 2022
Increasing the temperature by just a few degrees may lead to structural perturbation or unfolding of the protein and consequent loss of function. The concepts of flexibility and rigidity are fundamental for understanding the relationships between ...
Mahdie Rahban, S. Zolghadri, N. Salehi, F. Ahmad, T. Haertlé, N. Rezaei-Ghaleh, L. Sawyer, A. Saboury   +7 more
semanticscholar   +1 more source

Machine Learning for Biologics: Opportunities for Protein Engineering, Developability, and Formulation.

TIPS - Trends in Pharmacological Sciences, 2021
Successful biologics must satisfy multiple properties including activity and particular physicochemical features that are globally defined as developability.
H. Narayanan, F. Dingfelder, A. Butté, Nikolai Lorenzen, M. Sokolov, P. Arosio   +5 more
semanticscholar   +1 more source

Insertions and Deletions (Indels): A Missing Piece of the Protein Engineering Jigsaw.

Biochemistry, 2022
Over the years, protein engineers have studied nature and borrowed its tricks to accelerate protein evolution in the test tube. While there have been considerable advances, our ability to generate new proteins in the laboratory is seemingly limited.
C. Miton, N. Tokuriki
semanticscholar   +1 more source

Protein engineering for electrochemical biosensors.

Current Opinion in Biotechnology, 2022
The development of electrochemical biosensors has gained tremendous attention. Protein engineering has been applied for enhancing properties of native redox enzymes, such as selectivity, sensitivity, and stability required for applicable biosensors. This
Zhiguang Zhu, Haiyan Song, Yuan-Ming Wang, Yi-Heng Zhang   +3 more
semanticscholar   +1 more source

PyPEF - An Integrated Framework for Data-Driven Protein Engineering

Journal of Chemical Information and Modeling, 2021
Data-driven strategies are gaining increased attention in protein engineering due to recent advances in access to large experimental databanks of proteins, next-generation sequencing (NGS), high-throughput screening (HTS) methods, and the development of ...
Niklas E. Siedhoff, Alexander-Maurice Illig, U. Schwaneberg, M. Davari   +3 more
semanticscholar   +1 more source

Sortases: structure, mechanism, and implications for protein engineering.

TIBS -Trends in Biochemical Sciences. Regular ed
Sortase enzymes are critical cysteine transpeptidases on the surface of bacteria that attach proteins to the cell wall and are involved in the construction of bacterial pili.
Jeanine F. Amacher, J. Antos
semanticscholar   +1 more source

Structural bioinformatics-based protein engineering of thermo-stable PETase from Ideonella sakaiensis.

Enzyme and Microbial Technology, 2020
Poly(ethylene terephthalate) (PET), a widely used plastic around the world, causes various environmental and health problems. Several groups have been extensively conducting research to solve these problems through enzymatic degradation of PET at high ...
H. Son, S. Joo, Hogyun Seo, Hye-Young Sagong, Seul Hoo Lee, H. Hong, Kyung-Jin Kim   +6 more
semanticscholar   +1 more source