Results 231 to 240 of about 1,300,384 (288)

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Chemical Protein Engineering: Backbone Cyclization Rescues Folding of a 183-Residue Truncated Domain of Malaria Parasite Protein PfAMA1. [PDF]

Chemistry
Mannuthodikayil J, Malik V, Kar A, Singh S, Mandal K.   +4 more
europepmc   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Beyond small molecules: advancing MYC-targeted cancer therapies through protein engineering. [PDF]

Transcription
Edaibis R, Akel R, Shin JA.
europepmc   +1 more source

A systematic analysis of regression models for protein engineering. [PDF]

PLoS Comput Biol
Michael R, Kæstel-Hansen J, Mørch Groth P, Bartels S, Salomon J, Tian P, Hatzakis NS, Boomsma W.   +7 more
europepmc   +1 more source

Metabolic reprogramming and computation-aided protein engineering for high-level de novo biosynthesis for 2-phenylethanol in <i>Pichia pastoris</i>. [PDF]

Synth Syst Biotechnol
Sun L, Liu S, Sun R, Li J, Yu A, Wong A, Lin L, Zhang C.   +7 more
europepmc   +1 more source

The Protein Engineering of Zearalenone Hydrolase Results in a Shift in the pH Optimum of the Relative Activity of the Enzyme. [PDF]

Toxins (Basel)
Dotsenko A, Sinelnikov I, Zorov I, Denisenko Y, Rozhkova A, Shcherbakova L.   +5 more
europepmc   +1 more source

New advances in protein engineering for industrial applications: Key takeaways. [PDF]

Open Life Sci
Ndochinwa GO, Wang QY, Okoro NO, Amadi OC, Nwagu TN, Nnamchi CI, Moneke AN, Odiba AS.   +7 more
europepmc   +1 more source

Improving Downstream Process Related Manufacturability Based on Protein Engineering-A Feasibility Study. [PDF]

Eng Life Sci
Capito F, Wong TH, Faust C, Brand K, Dittrich W, Sommerfeld M, Tiwari G, Langer T.   +7 more
europepmc   +1 more source