Results 231 to 240 of about 8,703,040 (401)

Protein engineering as a strategy to avoid formation of amyloid fibrils [PDF]

, 2000
Sandra Villegas, Jesús Zurdo, Vladimir V. Filimonov, Francesc Avilés, Christopher M. Dobson, Luís Serrano   +5 more
openalex   +1 more source

Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer

Molecular Oncology, EarlyView.
We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas, Konstantinos Voutetakis, Vivian Kosmidou, Spyridon Tsikalakis, Spyridon Roditis, Konstantinos Pateas, Ryangguk Kim, Kymberleigh Pagel, Stephan Wolf, Gregor Warsow, Antonia Dimitrakopoulou‐Strauss, Georgios N. Zografos, Alexander Pintzas, Johannes Betge, Olga Papadodima, Stefan Wiemann   +15 more
wiley   +1 more source

Improving split-HaloTag through computational protein engineering. [PDF]

Protein Sci
Wilhelm J, Nickel L, Lin YH, Hiblot J, Johnsson K.   +4 more
europepmc   +1 more source

Protein engineering in the computational age: An open source framework for exploring mutational landscapes in silico. [PDF]

Eng Biol, 2023
Bamezai S, Maresca di Serracapriola G, Morris F, Hildebrandt R, Amil MAS, Sporadicate iGEM Team, Ledesma-Amaro R.   +6 more
europepmc   +1 more source

Studies on Structure, Function, and Protein Engineering of Starch-Degrading Enzymes.

, 1999
Birte Svensson, Kristian Sass Bak‐Jensen, Morten T. Jensen, Jørgen Sauer, Tine E. Gottschalk, Kees W. Rodenburg   +5 more
openalex   +2 more sources

Biosynthetic phage display: a novel protein engineering tool combining chemical and genetic diversity [PDF]

, 2000
Mary A. Dwyer, Wuyuan Lu, John J. Dwyer, Anthony A. Kossiakoff   +3 more
openalex   +1 more source

Multiplex single‐cell profiling of putative cancer stem cell markers ALDH1, SOX9, SOX2, CD44, CD133 and CD15 in endometrial cancer

Molecular Oncology, EarlyView.
Cancer stem cells are associated with aggressive disease, but a deep characterization of such markers is lacking in endometrial cancer. This study uses imaging mass cytometry to explore putative cancer stem cell markers in endometrial tumors and corresponding organoid models.
Hilde E. Lien, Marta E. Hjelmeland, Hege F. Berg, Rose M. Gold, Kathrine Woie, Lars A. Akslen, Ingfrid S. Haldorsen, Camilla Krakstad   +7 more
wiley   +1 more source

Benchmarking uncertainty quantification for protein engineering. [PDF]

PLoS Comput Biol
Greenman KP, Amini AP, Yang KK.
europepmc   +1 more source

Somatostatin Inhibits Akt Phosphorylation and Cell Cycle Entry, But Not p42/p44 Mitogen-Activated Protein (MAP) Kinase Activation in Normal and Tumoral Pancreatic Acinar Cells**This research was supported by Grant 970384 (to N.R.) from the Natural Sciences and Engineering Research Council of Canada. [PDF]

, 2001
Stéphanie Charland, Marie‐Josée Boucher, Mathieu Houde, Nathalie Rivard   +3 more
openalex   +1 more source

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

Molecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park, Jae Won Oh, Hyewon Chung, Jung Won Kwon, Yi Rang Na, Kwang Pyo Kim, Seung Hyeok Seok   +6 more
wiley   +1 more source