Results 251 to 260 of about 8,703,040 (401)

Optimizing longifolene production in Yarrowia lipolytica via metabolic and protein engineering. [PDF]

Synth Syst Biotechnol
Yao YT, Zhang X, Wang CY, Zhang YH, Li DW, Yang WD, Li HY, Zou LG.   +7 more
europepmc   +1 more source

An autoinhibited state of 53BP1 revealed by small molecule antagonists and protein engineering. [PDF]

Nat Commun, 2023
Cui G, Botuyan MV, Drané P, Hu Q, Bragantini B, Thompson JR, Schuller DJ, Detappe A, Perfetti MT, James LI, Frye SV, Chowdhury D, Mer G.   +12 more
europepmc   +1 more source

Classification of acute myeloid leukemia based on multi‐omics and prognosis prediction value

Molecular Oncology, EarlyView.
The Unsupervised AML Multi‐Omics Classification System (UAMOCS) integrates genomic, methylation, and transcriptomic data to categorize AML patients into three subtypes (UAMOCS1‐3). This classification reveals clinical relevance, highlighting immune and chromosomal characteristics, prognosis, and therapeutic vulnerabilities.
Yang Song, Zhe Wang, Guangji Zhang, Jiangxue Hou, Kaiqi Liu, Shuning Wei, Yan Li, Chunlin Zhou, Dong Lin, Min Wang, Hui Wei, Jianxiang Wang, Tao Cheng, Yingchang Mi   +13 more
wiley   +1 more source

Protein engineering using variational free energy approximation. [PDF]

Nat Commun
Lobzaev E, Herrera MA, Kasprzyk M, Stracquadanio G.   +3 more
europepmc   +1 more source

Engineering protein kinases with distinct nucleotide specificities and inhibitor sensitivities by mutation of a single amino acid

, 1998
Philip Cohen, Michel Goedert
openalex   +1 more source

Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi, Eric Feng, Nicholas R. Rydzewski, Amy K. Taylor, Jamie M. Sperger, Yue Shi, Kyle T. Helzer, Matthew L. Bootsma, Viridiana Carreno, Alex H. Chang, Luke A. Nunamaker, Grace C. Blitzer, Tianfu Andy Shang, Aishwarya Subramanian, Anders Bjartell, Andreas Josefsson, Pernilla Wikström, Emily Feng, Manish Kohli, Rendong Yang, Scott M. Dehm, Eric J. Small, Rahul Aggarwal, David A. Quigley, Joshua M. Lang, Shuang G. Zhao, Martin Sjöström   +26 more
wiley   +1 more source

Identification and Protein Engineering of Galactosidases for the Conversion of Blood Type B to Blood Type O. [PDF]

Chembiochem
Möller C, Terholsen H, Schmöker O, Lê TLA, Wesche J, Schmiade P, Eppendorfer E, Rimkus N, Girbardt B, Böttcher D, Palm GJ, Hoppen J, Lammers M, Greinacher A, Aurich K, Bornscheuer UT.   +15 more
europepmc   +1 more source

Rational protein engineering of a ketoacids decarboxylase for efficient production of 1,2,4-butanetriol from arabinose. [PDF]

Biotechnol Biofuels Bioprod, 2023
Shen X, Xu H, Wang T, Zhang R, Sun X, Yuan Q, Wang J.   +6 more
europepmc   +1 more source

Improvement of the 3'-5' Exonuclease Activity of Taq DNA Polymerase by Protein Engineering in the Active Site

, 1997
Yonghyun Park, Hyeja Choi, Dae Sil Lee, Young Soo Kim   +3 more
openalex   +1 more source

Engineering of the protein environment around the redox‐active TyrZ in photosystem II [PDF]

, 2001
Ronney Wiklund, Gaza F. Salih, Pirkko Mäenpää, Christer Jansson   +3 more
openalex   +1 more source