Results 61 to 70 of about 8,269,032 (242)

Phage-assisted evolution and protein engineering yield compact, efficient prime editors

Cell, 2023
Jordan L. Doman, Smriti Pandey, M. Neugebauer, Meirui An, Jessie R. Davis, Peyton B. Randolph, A. McElroy, Xin D. Gao, Aditya Raguram, M. Richter, Kelcee A. Everette, Samagya Banskota, Kathryn Tian, Y. A. Tao, J. Tolar, Mark J. Osborn, David R. Liu   +16 more
semanticscholar   +1 more source

Unified rational protein engineering with sequence-only deep representation learning

bioRxiv, 2019
Rational protein engineering requires a holistic understanding of protein function. Here, we apply deep learning to unlabelled amino acid sequences to distill the fundamental features of a protein into a statistical representation that is semantically ...
E. C. Alley, Grigory Khimulya, Surojit Biswas, Mohammed Alquraishi, George M. Church   +4 more
semanticscholar   +1 more source

Human acid sphingomyelinase structures provide insight to molecular basis of Niemann–Pick disease

Nature Communications, 2016
Genetic alterations in the protein acid sphingomyelinase (ASM) lead to ASM deficiency and have been associated with Niemann–Pick disease. Here, the authors report the crystal structures of ASM alone and bound to its product, and discuss the catalytic ...
Yan-Feng Zhou, Matthew C. Metcalf, Scott C. Garman, Tim Edmunds, Huawei Qiu, Ronnie R. Wei   +5 more
doaj   +1 more source

Adaptive machine learning for protein engineering [PDF]

Current Opinion in Structural Biology, 2021
Brian L. Hie, Kevin Kaichuang Yang
semanticscholar   +1 more source

Protein Engineering for Nicotinamide Coenzyme Specificity in Oxidoreductases: Attempts and Challenges

Frontiers in Microbiology, 2018
Oxidoreductases are ubiquitous enzymes that catalyze an extensive range of chemical reactions with great specificity, efficiency, and selectivity. Most oxidoreductases are nicotinamide cofactor-dependent enzymes with a strong preference for NADP or NAD ...
A. Chánique, Loreto P. Parra
semanticscholar   +1 more source

Protein Sensing with Engineered Protein Nanopores [PDF]

, 2012
The use of nanopores is a powerful new frontier in single-molecule sciences. Nanopores have been used effectively in exploring various biophysical features of small polypeptides and proteins, such as their folding state and structure, ligand interactions, and enzymatic activity.
Mohammad M. Mohammad, Liviu Movileanu
openaire   +3 more sources

Correction: Galectins use N-glycans of FGFs to capture growth factors at the cell surface and fine-tune their signaling

Cell Communication and Signaling, 2023
Aleksandra Gedaj, Dominika Zukowska, Natalia Porebska, Marta Pozniak, Mateusz Krzyscik, Aleksandra Czyrek, Daniel Krowarsch, Malgorzata Zakrzewska, Jacek Otlewski, Lukasz Opalinski   +9 more
doaj   +1 more source

Preclinical Characterization of Efficacy and Pharmacodynamic Properties of Finotonlimab, a Humanized Anti-PD-1 Monoclonal Antibody

Pharmaceuticals
Background/Objectives: Finotonlimab (SCTI10A) is a humanized anti-PD-1 antibody tested in Phase III trials for several solid tumor types. Methods: This study characterized the in vitro and in vivo efficacy, Fc-mediated effector function, and non-clinical
Yunqi Yao, Xiaoning Yang, Jing Li, Erhong Guo, Huiyu Wang, Chunyun Sun, Zhangyong Hong, Xiao Zhang, Jilei Jia, Rui Wang, Juan Ma, Yaqi Dai, Mingjing Deng, Chulin Yu, Lingling Sun, Liangzhi Xie   +15 more
doaj   +1 more source

Combining chemistry and protein engineering for new-to-nature biocatalysis

Nature Synthesis, 2022
David C. Miller, S. Athavale, F. Arnold
semanticscholar   +1 more source

Persistent spectral theory-guided protein engineering

bioRxiv, 2022
Yuchi Qiu, Guo-Wei Wei
semanticscholar   +1 more source