Results 41 to 50 of about 9,762,259 (268)
CatalystsProtein engineering has emerged as a transformative field in industrial biotechnology, enabling the optimization of enzymes to meet stringent industrial demands for stability, specificity, and efficiency.
Konstantinos Grigorakis +2 more
semanticscholar +1 more source
Artificial intelligence-powered biofoundries for protein engineering and metabolic engineering.
Current Opinion in BiotechnologySynthetic biology is rapidly evolving through the integration of artificial intelligence (AI) and automated biofoundries. This convergence accelerates the design-build-test-learn cycle, shifting protein engineering and metabolic engineering from labor ...
Jun-Yu Chen +4 more
semanticscholar +1 more source
Interpretable and explainable predictive machine learning models for data-driven protein engineering
bioRxivProtein engineering using directed evolution and (semi)rational design has emerged as a powerful strategy for optimizing and enhancing enzymes or proteins with desired properties.
David Medina-Ortiz +3 more
semanticscholar +1 more source
Protein engineering for improving and diversifying natural products biosynthesis
Trends in Biotechnology, 2020 Proteins found in nature have traditionally been the most frequently used biocatalysts to produce numerous natural products ranging from commodity chemicals to pharmaceuticals. Protein engineering has emerged as a powerful biotechnological toolbox in the
Chenyi Li +4 more
semanticscholar +1 more source
A novel one-step approach for the construction of yeast surface display Fab antibody libraries
Microbial Cell Factories, 2018 Background Yeast surface display (YSD) has proven to be a versatile platform technology for antibody discovery. However, the construction of antibody Fab libraries typically is a tedious three-step process that involves the generation of heavy chain as ...
Simon Rosowski +10 more
doaj +1 more source
Nature Communications, 2022 Peptide fragments derived from the interfaces of protein-protein interactions (PPIs) provide useful templates for designing small molecule PPI inhibitors.
Xiyao Cheng +8 more
doaj +1 more source
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Introduction This study investigated the safety and efficacy of single‐needle Rheocarna therapy for chronic limb‐threatening ischemia (CLTI) with wounds. Methods Six patients with CLTI involving ulcers unresponsive to revascularization underwent single‐needle Rheocarna treatment.
Yasutaka Yamauchi +9 more
wiley +1 more source
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Introduction Hyperlipidemia is a major risk factor for atherosclerotic cardiovascular disease (ASCVD). Although statins are the cornerstone of lipid‐lowering therapy, their use may be limited in some patients by adverse effects. This study evaluated the possible impact of non‐drug treatment using double‐filtration plasmapheresis (DFPP) on CD14+
Yun Cheng +3 more
wiley +1 more source
Cell Communication and SignalingGalectins constitute a class of lectins that specifically interact with β-galactoside sugars in glycoconjugates and are implicated in diverse cellular processes, including transport, autophagy or signaling. Since most of the activity of galectins depends
Aleksandra Gędaj +9 more
doaj +1 more source
FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source