Results 41 to 50 of about 765,059 (313)

The intracellular interplay between galectin-1 and FGF12 in the assembly of ribosome biogenesis complex

Cell Communication and Signaling
Galectins constitute a class of lectins that specifically interact with β-galactoside sugars in glycoconjugates and are implicated in diverse cellular processes, including transport, autophagy or signaling. Since most of the activity of galectins depends
Aleksandra Gędaj, Aleksandra Chorążewska, Krzysztof Ciura, Radosław Karelus, Dominika Żukowska, Martyna Biaduń, Marta Kalka, Małgorzata Zakrzewska, Natalia Porębska, Łukasz Opaliński   +9 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Protein engineering techniques: gateways to synthetic protein universe

, 2017
This brief provides a broad overview of protein-engineering research, offering a glimpse of the most common experimental methods. It also presents various computational programs with applications that are widely used in directed evolution, computational ...
Poluri, Krishna Mohan, Gulati, Khushboo
core   +1 more source

Antibody-induced dimerization of FGFR1 promotes receptor endocytosis independently of its kinase activity

Scientific Reports, 2017
Fibroblast growth factors (FGFs) and their plasma membrane-localized receptors (FGFRs) play a key role in the regulation of developmental processes and metabolism.
Łukasz Opaliński, Aleksandra Sokołowska-Wędzina, Martyna Szczepara, Małgorzata Zakrzewska, Jacek Otlewski   +4 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Improvement of downstream processing of recombinant proteins by means of genetic engineering

, 1993
Flaschel E, Friehs K. Improvement of downstream processing of recombinant proteins by means of genetic engineering. Biotechnology Advances. 1993;11(1):31-77.The rapid advancement of genetic engineering has allowed to produce an impressive number of ...
Flaschel, Erwin, Friehs, Karl
core   +1 more source

Linking Genotype and Phenotype of Saccharomyces cerevisiae Strains Reveals Metabolic Engineering Targets and Leads to Triterpene Hyper-Producers [PDF]

, 2011
Background: Metabolic engineering is an attractive approach in order to improve the microbial production of drugs. Triterpenes is a chemically diverse class of compounds and many among them are of interest from a human health perspective.
Otero, Jose M., Otero, JM, Koetter, P, Jens Nielsen, Semba, Saori, Tetsuo Kushiro, Karina M Madsen, Nielsen, Jens B, Ebizuka, Yutaka, Jose M. Otero, Kötter, Peter, Gupta D. B. R. K. Udatha, Udatha, Gupta D. B. R. K., Semba, S, Yutaka Ebizuka, Otero Jose M., Jose M Otero, Nielsen, Jens, Panagiotou, Gianni, Panagiotou Gianni, Nielsen, J, Panagiotou, G, Gianni Panagiotou, Madsen Karina M., Udatha Gupta D. B. R. K., Semba Saori, Udatha, Gupta, Madsen, KM, Ebizuka, Y, Madsen, Karina Marie, Madsen, Karina M., Karina M. Madsen, Saori Semba, Udatha, GDBRK, Koetter Peter, Otero, Jos\ue9 Manuel, Otero Romero, José Manuel, Kushiro Tetsuo, Gupta D B R K Udatha, Ebizuka Yutaka, Kushiro, Tetsuo, Koetter, Peter, Kushiro, T, Udatha, D.B.R.K. Gupta, Nielsen Jens, Nielsen, Jens B., Peter Koetter   +46 more
core   +1 more source

Phosphoglycerate dehydrogenase promotes pancreatic cancer development by interacting with eIF4A1 and eIF4E

Journal of Experimental & Clinical Cancer Research, 2019
Background Pancreatic cancer is one of the most malignant cancers. The overall 5-year survival rate of its patients is 8%, the lowest among major cancer types.
Xuhui Ma, Boya Li, Jie Liu, Yan Fu, Yongzhang Luo   +4 more
doaj   +1 more source

Beyond bispecificity: Controlled Fab arm exchange for the generation of antibodies with multiple specificities

mAbs, 2022
Controlled Fab arm exchange (cFAE) has proven to be a generic and versatile technology for the efficient generation of IgG-like bispecific antibodies (DuoBodies or DBs), with several in clinical development and one product, amivantamab, approved by the ...
Desislava Yanakieva, Lukas Pekar, Andreas Evers, Markus Fleischer, Stephan Keller, Dirk Mueller-Pompalla, Lars Toleikis, Harald Kolmar, Stefan Zielonka, Simon Krah   +9 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source