Results 31 to 40 of about 9,762,259 (268)
Protein Engineering Strategies for Improved Pharmacokinetics
Advanced Functional Materials, 2021 Protein therapeutics have gained momentum in recent years and become a pillar in treating many diseases and the only choice in several ailments. Protein therapeutics are highly specific, tunable, and less toxic than conventional small drug molecules ...
Aurélie Rondon +4 more
semanticscholar +1 more source
A Novel T Cell-Engaging Bispecific Antibody for Treating Mesothelin-Positive Solid Tumors
Biomolecules, 2020 As mesothelin is overexpressed in various types of cancer, it is an attractive target for therapeutic antibodies. T-cell bispecific antibodies bind to target cells and engage T cells via binding to CD3, resulting in target cell killing by T-cell ...
Aerin Yoon +8 more
doaj +1 more source
Unified rational protein engineering with sequence-based deep representation learning
Nature Methods, 2019 Rational protein engineering requires a holistic understanding of protein function. Here, we apply deep learning to unlabeled amino-acid sequences to distill the fundamental features of a protein into a statistical representation that is semantically ...
E. C. Alley +4 more
semanticscholar +1 more source
Substrate multiplexed protein engineering facilitates promiscuous biocatalytic synthesis
Nature Communications, 2021 Enzymes with high activity are readily produced through protein engineering, but intentionally and efficiently engineering enzymes for an expanded substrate scope is a contemporary challenge.
Allwin D. McDonald +2 more
semanticscholar +1 more source
Frontiers in Immunology, 2023 In this work we present a novel symmetric bispecific antibody format based on engraftments of cattle-derived knob paratopes onto peripheral loops of the IgG1 Fc region.
Desislava Yanakieva +11 more
doaj +1 more source
Solid-phase synthesis of protein-polymers on reversible immobilization supports
Nature Communications, 2018 Synthesis of protein-polymer conjugates typically relies on multi-step processes in solution and on challenging purification strategies. Here the authors show a robust synthesis approach which eliminates purification processes by immobilizing proteins ...
Hironobu Murata +4 more
doaj +1 more source
Versatile and rapid microfluidics-assisted antibody discovery
mAbs, 2021 Recent years have seen unparalleled development of microfluidic applications for antibody discovery in both academic and pharmaceutical research. Microfluidics can support native chain-paired library generation as well as direct screening of antibody ...
Ramona Gaa +5 more
doaj +1 more source
mAbs, 2020 The ability to genetically encode non-natural amino acids (nnAAs) into proteins offers an expanded tool set for protein engineering. nnAAs containing unique functional moieties have enabled the study of post-translational modifications, protein ...
Gargi Roy +11 more
doaj +1 more source
Molecular mechanism of CCDC106 regulating the p53-Mdm2/MdmX signaling axis
Scientific Reports, 2023 The tumor suppressor p53 (p53) is regulated by murine double minute 2 (Mdm2) and its homologous MdmX in maintaining the basal level of p53. Overexpressed Mdm2/MdmX inhibits cellular p53 activity, which is highly relevant to cancer occurrence. Coiled-coil
Ting Zhou +7 more
doaj +1 more source
Young and Undamaged rMSA Improves the Healthspan and Lifespan of Mice
Biomolecules, 2021 Improvement of longevity is an eternal dream of human beings. The accumulation of protein damages is considered as a major cause of aging. Here, we report that the injection of exogenous recombinant mouse serum albumin (rMSA) reduced the total damages of
Jiaze Tang +9 more
doaj +1 more source