Results 71 to 80 of about 8,269,032 (242)

Thermophilic Proteins as Versatile Scaffolds for Protein Engineering

Microorganisms, 2018
Literature from the past two decades has outlined the existence of a trade-off between protein stability and function. This trade-off creates a unique challenge for protein engineers who seek to introduce new functionality to proteins.
A. Finch, J. Kim
semanticscholar   +1 more source

Protein engineering: Hydrogen bonds in active sites [PDF]

, 1985
John Galloway
openalex   +1 more source

Protein engineering via Bayesian optimization-guided evolutionary algorithm and robotic experiments

bioRxiv, 2022
Ruyun Hu, Lihao Fu, Yongcan Chen, Junyu Chen, Yu Qiao, Tong Si   +5 more
semanticscholar   +1 more source

Protein Engineering of Dihydrofolate Reductase. pH Dependency of Phe-31 Mutants [PDF]

, 1987
Kazunari Taira, Jin-Tann Chen, Carol A. Fierke, Stephen J. Benkovic   +3 more
openalex   +1 more source

Low Stability of Integrin-Binding Deficient Mutant of FGF1 Restricts Its Biological Activity

Cells, 2019
Fibroblast growth factor 1 (FGF1) has been shown to interact with integrin αvβ3 through a specific binding site, involving Arg35 residue. The FGF1 mutant (R35E) with impaired integrin binding was found to be defective in its proliferative ...
Anna Szlachcic, Martyna Sochacka, Aleksandra Czyrek, Lukasz Opalinski, Daniel Krowarsch, Jacek Otlewski, Malgorzata Zakrzewska   +6 more
doaj   +1 more source

Improving the DNA specificity and applicability of base editing through protein engineering and protein delivery

Nature Communications, 2017
We recently developed base editing, a genome-editing approach that enables the programmable conversion of one base pair into another without double-stranded DNA cleavage, excess stochastic insertions and deletions, or dependence on homology-directed ...
H. Rees, Alexis C. Komor, Wei-Hsi Yeh, J. Caetano-Lopes, M. Warman, A. Edge, David R. Liu   +6 more
semanticscholar   +1 more source

Protein engineering Tutorials in molecular and cell biology [PDF]

, 1988
M. James C. Crabbe
openalex   +1 more source

Machine learning to navigate fitness landscapes for protein engineering.

Current Opinion in Biotechnology, 2022
Chase R. Freschlin, Sarah A Fahlberg, Philip A. Romero   +2 more
semanticscholar   +1 more source

Genetic engineering: Eukaryotic proteins retargetted among cell compartments [PDF]

, 1985
John Ellis
openalex   +1 more source

Immunogenicity Assessment of a 14-Valent Human Papillomavirus Vaccine Candidate in Mice

Vaccines
Background: Cervical cancer ranks as the fourth most common cancer affecting women globally, with HPV as the primary etiology agent. Prophylactic HPV vaccines have substantially reduced the incidence of cervical cancer.
Lei Bei, Shuman Gao, Dandan Zhao, Yajuan Kou, Siyu Liang, Yurong Wu, Xiao Zhang, Dan Meng, Jianbo Lu, Chunxia Luo, Xuefeng Li, Yang Wang, Hongbin Qiu, Liangzhi Xie   +13 more
doaj   +1 more source