Results 191 to 200 of about 29,093 (266)

Genetic insights into SGLT2 inhibition and atrial fibrillation: exploring the mediating role of inflammatory proteins. [PDF]

Cardiol J
Yi C, Zheng W, Wang J, Li W, Zhang Y, Zhou D, Lei P, Wang Y, Bai M, Zhang Z.   +9 more
europepmc   +1 more source

In silico peptide self‐assembly reveals the importance of N‐terminal motifs and the inhibition mechanism of the mutation L38M in α‐synuclein fibrillation

Protein Science, Volume 35, Issue 4, April 2026.
Abstract Alpha‐synuclein (αSyn) is a presynaptic protein associated with several neurodegenerative diseases. While the non‐amyloid component (NAC) region of the αSyn sequence (residues 65–90) forms the core of all αSyn fibrils, recent findings suggest that the flanking regions play a key role in initiating or preventing amyloid formation. Two motifs in
Van T. T. Nguyen, Sabine M. Ulamec, David J. Brockwell, Sheena E. Radford, Carol K. Hall   +4 more
wiley   +1 more source

Innate immune activation and mitochondrial ROS induce acute and persistent cardiac conduction system dysfunction after COVID-19. [PDF]

JCI Insight
Ashok D, Liu T, Nakanishi-Koakutsu M, Criscione J, Prakash M, Tensfeldt A, Kim B, Ho B, Chow J, Craney M, Ranek MJ, Lin BL, Papanicolaou K, Sidor A, Foster DB, Cho HC, Pekosz A, Villano J, Kim DH, O'Rourke B.   +19 more
europepmc   +1 more source

Small heat shock proteins HspB1 and HspB5 differentially alter the condensation and aggregation of the TDP‐43 low‐complexity domain

Protein Science, Volume 35, Issue 4, April 2026.
Abstract TAR DNA‐binding protein 43 (TDP‐43) is a nucleic acid‐binding protein that regulates processes of mRNA metabolism, during which it undergoes condensation mediated by its C‐terminal low‐complexity domain (TDP‐43LCD). TDP‐43 aggregation and condensation are associated with neurodegenerative disease.
Thomas B. Walker, Joshua W. Trowbridge, Shannon McMahon, Nicholas R. Marzano, Lauren Rice, Justin J. Yerbury, Heath Ecroyd, Luke McAlary   +7 more
wiley   +1 more source

Emerging antiarrhythmic drug therapy for atrial fibrillation. [PDF]

Heart Rhythm O2
Lubitz SA, Taggart AKP, Gimpelewicz C, O'Donnell CJ.   +3 more
europepmc   +1 more source

Amiodarone‐Induced Pulmonary Toxicity With Confirmed Elevated Plasma Mono‐Desethyl‐Amiodarone Levels

Respirology Case Reports, Volume 14, Issue 4, April 2026.
We report a case of pulmonary toxicity that developed 10 months after the initiation of amiodarone. The serum mono‐desethyl‐amiodarone concentration was elevated despite the relatively low cumulative amiodarone dose. ABSTRACT Amiodarone hydrochloride is an effective antiarrhythmic drug that can cause serious adverse effects, including amiodarone ...
Munechika Hara, Miki Kato, Fumika Sugiyama, Ryo Ichikawa, Tsutomu Hachiya   +4 more
wiley   +1 more source

Atrial fibroblast-derived macrophage migration inhibitory factor promotes atrial macrophage accumulation in postoperative atrial fibrillation. [PDF]

JCI Insight
Keefe JA, Navarro-Garcia JA, Zhao S, Chelu MG, Wehrens XH.   +4 more
europepmc   +1 more source

Artificial intelligence streamlines scientific discovery of drug–target interactions

British Journal of Pharmacology, Volume 183, Issue 8, Page 1673-1690, April 2026.
Abstract Drug discovery is a complicated process through which new therapeutics are identified to prevent and treat specific diseases. Identification of drug–target interactions (DTIs) stands as a pivotal aspect within the realm of drug discovery and development. The traditional process of drug discovery, especially identification of DTIs, is marked by
Yuxin Yang, Feixiong Cheng
wiley   +1 more source

In silico analysis of atrial fibrillation and hypertension mechanism of action secondary to ibrutinib/acalabrutinib in chronic lymphocytic leukemia. [PDF]

Sci Rep
Córdoba R, Bayés-Genís A, Muntañola A, Colomer D, Castro J, Leiva C, Álvarez E, Zatarain-Nicolas E.   +7 more
europepmc   +1 more source