Results 51 to 60 of about 132,897 (299)
The relationship between amyloid structure and cytotoxicity [PDF]
, 2014 Self-assembly of proteins and peptides into amyloid structures has been the subject of intense and focused research due to their association with neurodegenerative, age-related human diseases and transmissible prion diseases in humans and mammals. Of the
Marchante, Ricardo +3 more
core +1 more source
BMC Biotechnology, 2011 Background Fluorescent tags, including small organic molecules and fluorescent proteins, enable the localization of protein molecules in biomedical research experiments.
Anderson Valerie L, Webb Watt W
doaj +1 more source
PLoS ONE, 2021 Amyloid fibrils are widely studied both as target in conformational disorders and as basis for the development of protein-based functional materials.
Svitlana Chernii +9 more
doaj +1 more source
Inhibition by small-molecule ligands of formation of amyloid fibrils of an immunoglobulin light chain variable domain. [PDF]
, 2015 Overproduction of immunoglobulin light chains leads to systemic amyloidosis, a lethal disease characterized by the formation of amyloid fibrils in patients' tissues. Excess light chains are in equilibrium between dimers and less stable monomers which can
Brumshtein, Boris +7 more
core +1 more source
Nanoscale imaging of major and minor ampullate silk from the orb-web spider Nephila Madagascariensis
Scientific Reports, 2023 Spider silk fibres have unique mechanical properties due to their hierarchical structure and the nanoscale organization of their proteins. Novel imaging techniques reveal new insights into the macro- and nanoscopic structure of Major (MAS) and Minor (MiS)
Irina Iachina +4 more
doaj +1 more source
European Journal of Medicinal Chemistry Reports, 2023 The accumulation, processing and toxicity of Aβ can be affected by interacting with transthyretin (TTR). We obtained 31 compounds with different structures by virtual screening based on protein structure.
Fantao Sun +5 more
doaj +1 more source
Regulation of Synaptic Pumilio Function by an Aggregation-Prone Domain [PDF]
, 2010 We identified Pumilio (Pum), a Drosophila translational repressor, in a computational search for metazoan proteins whose activities might be regulated by assembly into ordered aggregates.
Menon, Kaushiki P. +3 more
core +2 more sources
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Using molecular mechanics to predict bulk material properties of fibronectin fibers [PDF]
, 2012 The structural proteins of the extracellular matrix (ECM) form fibers with finely tuned mechanical properties matched to the time scales of cell traction forces.
Bradshaw, Mark J. +3 more
core +2 more sources
Protein Microgels from Amyloid Fibril Networks [PDF]
, 2019 Nanofibrillar forms of amyloidogenic proteins were initially discovered in the context of protein misfolding and disease but have more recently been found at the origin of key biological functionality in many naturally occurring functional materials, such as adhesives and biofilm coatings.
Lianne W Y, Roode +4 more
openaire +2 more sources