Results 181 to 190 of about 6,771,465 (361)

Co‐translational folding of nascent polypeptides: Multi‐layered mechanisms for the efficient biogenesis of functional proteins

, 2021
Kevin Maciuba, Nandakumar Rajasekaran, Xiuqi Chen, Christian Kaiser   +3 more
openalex   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Rapid estimation of protein folding pathways from sequence alone using AlphaFold2. [PDF]

Nat Commun
Chang L, Perez A.
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Osmolyte Structural and Thermodynamic Effects Across the Protein Folding Landscape. [PDF]

JACS Au
Pereira AF, Martínez L.
europepmc   +1 more source

Stochastic strategy to analyze protein folding

, 2005
Marcelo A. Moret, Paulo M. Bisch, E. Nogueira, Pedro G. Pascutti   +3 more
openalex   +2 more sources

The IntFOLD server: an integrated web resource for protein fold recognition, 3D model quality assessment, intrinsic disorder prediction, domain prediction and ligand binding site prediction [PDF]

, 2011
Daniel B. Roche, Maria T. Buenavista, Stuart Tetchner, Liam J. McGuffin   +3 more
openalex   +1 more source

Global analysis of protein folding using massively parallel design, synthesis, and testing

Science, 2017
G. Rocklin, T. M. Chidyausiku, Inna Goreshnik, Alex Ford, S. Houliston, A. Lemak, L. Carter, Rashmi Ravichandran, V. Mulligan, A. Chevalier, C. Arrowsmith, D. Baker   +11 more
semanticscholar   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

The Arch from the Stones: Understanding Protein Folding Energy Landscapes via Bioinspired Collective Variables. [PDF]

J Phys Chem Lett
Rizzi V, Héritier M, Piasentin N, Aureli S, Gervasio FL.   +4 more
europepmc   +2 more sources