Results 51 to 60 of about 6,771,465 (361)

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Comparing the Folds of Prions and Other Pathogenic Amyloids

Pathogens, 2018
Pathogenic amyloids are the main feature of several neurodegenerative disorders, such as Creutzfeldt–Jakob disease, Alzheimer’s disease, and Parkinson’s disease. High resolution structures of tau paired helical filaments (PHFs), amyloid-
José Miguel Flores-Fernández, Vineet Rathod, Holger Wille   +2 more
doaj   +1 more source

Cellular Biology of Tau Diversity and Pathogenic Conformers

Frontiers in Neurology, 2020
Tau accumulation is a prominent feature in a variety of neurodegenerative disorders and remarkable effort has been expended working out the biochemistry and cell biology of this cytoplasmic protein.
Sang-Gyun Kang, Ghazaleh Eskandari-Sedighi, Lenka Hromadkova, Jiri G. Safar, David Westaway, David Westaway   +5 more
doaj   +1 more source

Protein folding

Bioscience Reports, 1988
The importance of protein folding in the biosynthesis of proteins is reviewed.
openaire   +2 more sources

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

Single time-point analysis of product and substrate inhibition

Scientific Reports
When enzyme inhibition by either the product or excess substrate occurs, it is possible to determine the characteristic kinetic parameters based on [P]/t measurements, even when a large proportion of the substrate is converted.
Olivier Verlaine, Romain Malempré, Wim Versées, André Matagne, Jean-Marie Frère   +4 more
doaj   +1 more source

White-tailed deer S96 prion protein does not support stable in vitro propagation of most common CWD strains

Scientific Reports, 2021
PrPC variation at residue 96 (G/S) plays an important role in the epidemiology of chronic wasting disease (CWD) in exposed white-tailed deer populations.
Alicia Otero, Camilo Duque Velásquez, Judd Aiken, Debbie McKenzie   +3 more
doaj   +1 more source

Predicting protein folding pathways [PDF]

Bioinformatics, 2004
Abstract Summary: A structured folding pathway, which is a time ordered sequence of folding events, plays an important role in the protein folding process and hence, in the conformational search. Pathway prediction, thus gives more insight into the folding process and is a valuable guiding tool to search the conformation space.
Mohammed J, Zaki, Vinay, Nadimpally, Deb, Bardhan, Chris, Bystroff   +3 more
openaire   +3 more sources

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

FEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

Chronic wasting disease: a cervid prion infection looming to spillover

Veterinary Research, 2021
The spread of chronic wasting disease (CWD) during the last six decades has resulted in cervid populations of North America where CWD has become enzootic.
Alicia Otero, Camilo Duque Velásquez, Judd Aiken, Debbie McKenzie   +3 more
doaj   +1 more source