Results 31 to 40 of about 3,672,982 (262)
The Protein Folding Problem [PDF]
Annual Review of Biophysics, 2008 The “protein folding problem” consists of three closely related puzzles: (a) What is the folding code? (b) What is the folding mechanism? (c) Can we predict the native structure of a protein from its amino acid sequence? Once regarded as a grand challenge, protein folding has seen great progress in recent years.
Dill, K. +3 more
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Comparing the folding and misfolding energy landscapes of phosphoglycerate kinase. [PDF]
, 2011 Partitioning of polypeptides between protein folding and amyloid formation is of outstanding pathophysiological importance. Using yeast phosphoglycerate kinase as model, here we identify the features of the energy landscape that decide the fate of the ...
Gottfried Köhler +7 more
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Chaos of protein folding [PDF]
The 2011 International Joint Conference on Neural Networks, 2011 As protein folding is a NP-complete problem, artificial intelligence tools like neural networks and genetic algorithms are used to attempt to predict the 3D shape of an amino acids sequence. Underlying these attempts, it is supposed that this folding process is predictable.
Jacques M. Bahi +2 more
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Properties of the free energy barriers for folding of the [alpha]-amylase inhibitor tendamistat [PDF]
, 2005 The goal of this work was to improve our understanding of the properties of the free energy barriers in protein folding. We used the small all-[beta]-sheet protein tendamistat as a model protein. Tendamistat contains two disulfide bridges and folds and
Schätzle, Manuela
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Mechanisms of evolutionary optimized complex folding reactions [PDF]
, 2007 The mechanisms and speed limits of evolutionary optimized complex folding reactions were investigated in this study. The two viral model proteins, foldon and SFVP, have evolved under selective pressure for fast and efficient folding and association.
Güthe, Sarah
core +1 more source
Frontiers in Neuroscience, 2015 Organotypic cerebellar slices represent a suitable model for characterizing and manipulating prion replication in complex cell environments. Organotypic slices recapitulate prion pathology and are amenable to drug testing in the absence of a blood-brain ...
Hanna eWolf +7 more
doaj +1 more source
Dynamics in unfolded polypeptide chains as model for elementary steps in protein folding [PDF]
, 2004 This thesis deals with the dynamics of unfolded polypeptide chains as model for the earliest steps in protein folding. Starting from an ensemble of unfolded conformations a folding polypeptide chain has to form specific backbone and side-chain ...
Krieger, Florian
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Single-molecule fluorescence studies of Protein Folding and Molecular Chaperones [PDF]
, 2011 Folding of newly synthesized proteins is an essential part of protein biosynthesis and misfolding can result in protein aggregation which can also lead to several severe diseases.
Sikor, Martin
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Biomolecules, 2020 Prion diseases are fatal, transmissible neurodegenerative disorders whose pathogenesis is driven by the misfolding, self-templating and cell-to-cell spread of the prion protein.
Hailey Pineau, Valerie Sim
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The Structure of Human Prions: From Biology to Structural Models—Considerations and Pitfalls
Viruses, 2014 The Structure of Human Prions: From Biology to Structural Models — Considerations and ...
Claudia Y. Acevedo-Morantes +1 more
doaj +1 more source