Results 21 to 30 of about 255,418 (267)
Progress in Nuclear Magnetic Resonance Spectroscopy, 2017 Protein folding is a highly complex process proceeding through a number of disordered and partially folded nonnative states with various degrees of structural organization. These transiently and sparsely populated species on the protein folding energy landscape play crucial roles in driving folding toward the native conformation, yet some of these ...
Zhuravleva, A, Korzhnev, DM
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Biomolecules, 2020 Prion diseases are fatal, transmissible neurodegenerative disorders whose pathogenesis is driven by the misfolding, self-templating and cell-to-cell spread of the prion protein.
Hailey Pineau, Valerie Sim
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Sheep scrapie and deer rabies in England prior to 1800
Prion, 2023 Eighteenth-century England witnessed the emergence of two neurological diseases in animals. Scrapie, a transmissible spongiform encephalopathy, is a fatal neurodegenerative disease of sheep and goats that appears in classical and atypical forms.
Anthony Ness +2 more
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Folding nuclei in proteins [PDF]
FEBS Letters, 2001 When a protein folds or unfolds, it passes through many half‐folded microstates. Only a few of them can accumulate and be seen experimentally, and this happens only when the folding (or unfolding) occurs far from the point of thermodynamic equilibrium between the native and denatured states.
Galzitskaya, Oxana V +2 more
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The Structure of Human Prions: From Biology to Structural Models—Considerations and Pitfalls
Viruses, 2014 The Structure of Human Prions: From Biology to Structural Models — Considerations and ...
Claudia Y. Acevedo-Morantes +1 more
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Pharmaceutics, 2020 Clinical symptoms of Alzheimer’s Disease (AD) include behavioral alterations and cognitive impairment. These functional phenotypes early occur in triple-transgenic (3xTg-AD) mice.
Alejandro R. Roda +3 more
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BiomoleculesSlow-onset neurodegenerative disease in a low-expresser 2N4R P301L transgenic (Tg) mouse model is marked by neuroinflammation and by differing patterns of CNS deposition and accumulation of tau conformers, with such heterogeneities present even within ...
Nathalie Daude +4 more
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The Protein Folding Network [PDF]
Journal of Molecular Biology, 2004 The conformation space of a 20-residue antiparallel $ $-sheet peptide, sampled by molecular dynamics simulations, is mapped to a network. Conformations are nodes of the network, and the transitions between them are links. The conformation space network describes the significant free energy minima and their dynamic connectivity without projections into
Rao, Francesco, Caflisch, Amedeo
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Protein folds vs. protein folding: Differing questions, different challenges
Proceedings of the National Academy of Sciences, 2022 No ...
Shi-Jie Chen +23 more
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Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Kaposiform lymphangiomatosis (KLA) is an aggressive complex lymphatic anomaly. Patients exhibit malformed lymphatic vessels and often develop hemorrhagic effusions and elevated angiopoietin‐2 (Ang‐2) levels. A somatic NRAS p.Q61R (NRASQ61R) mutation has been associated with KLA.
C. Griffin McDaniel +3 more
wiley +1 more source