Results 21 to 30 of about 259,716 (267)
Journal of Nanobiotechnology, 2023 Evidence suggests that increased level/aggregation of β-amyloid (Aβ) peptide, together with enhanced phosphorylation/aggregation of tau protein, play a critical role in the development of Alzheimer’s disease (AD), the leading cause of dementia in the ...
Karthivashan Govindarajan +1 more
doaj +1 more source
The Protein Folding Problem [PDF]
Annual Review of Biophysics, 2008 The “protein folding problem” consists of three closely related puzzles: (a) What is the folding code? (b) What is the folding mechanism? (c) Can we predict the native structure of a protein from its amino acid sequence? Once regarded as a grand challenge, protein folding has seen great progress in recent years.
Dill, K. +3 more
openaire +3 more sources
Octarepeat region flexibility impacts prion function, endoproteolysis and disease manifestation
EMBO Molecular Medicine, 2015 The cellular prion protein (PrPC) comprises a natively unstructured N‐terminal domain, including a metal‐binding octarepeat region (OR) and a linker, followed by a C‐terminal domain that misfolds to form PrPSc in Creutzfeldt‐Jakob disease.
Agnes Lau +19 more
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Chaos of protein folding [PDF]
The 2011 International Joint Conference on Neural Networks, 2011 As protein folding is a NP-complete problem, artificial intelligence tools like neural networks and genetic algorithms are used to attempt to predict the 3D shape of an amino acids sequence. Underlying these attempts, it is supposed that this folding process is predictable.
Jacques M. Bahi +2 more
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Movement of Chronic Wasting Disease Prions in Prairie, Boreal and Alpine Soils
Pathogens, 2023 Chronic wasting disease (CWD) is a transmissible spongiform encephalopathy negatively impacting cervids on three continents. Soil can serve as a reservoir for horizontal transmission of CWD by interaction with the infectious prion protein (PrPCWD) shed ...
Alsu Kuznetsova +4 more
doaj +1 more source
Frontiers in Neuroscience, 2015 Organotypic cerebellar slices represent a suitable model for characterizing and manipulating prion replication in complex cell environments. Organotypic slices recapitulate prion pathology and are amenable to drug testing in the absence of a blood-brain ...
Hanna eWolf +7 more
doaj +1 more source
PROTEIN FOLDING AND HETEROPOLYMERS [PDF]
, 1997 57 pages, 7 figures. Uses lprocl.sty (included). To appear in " Spin glasses and random fields ", A.P.
Garel, Thomas +2 more
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Biomolecules, 2020 Prion diseases are fatal, transmissible neurodegenerative disorders whose pathogenesis is driven by the misfolding, self-templating and cell-to-cell spread of the prion protein.
Hailey Pineau, Valerie Sim
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Sheep scrapie and deer rabies in England prior to 1800
Prion, 2023 Eighteenth-century England witnessed the emergence of two neurological diseases in animals. Scrapie, a transmissible spongiform encephalopathy, is a fatal neurodegenerative disease of sheep and goats that appears in classical and atypical forms.
Anthony Ness +2 more
doaj +1 more source
The Structure of Human Prions: From Biology to Structural Models—Considerations and Pitfalls
Viruses, 2014 The Structure of Human Prions: From Biology to Structural Models — Considerations and ...
Claudia Y. Acevedo-Morantes +1 more
doaj +1 more source