Results 61 to 70 of about 6,813,928 (408)
Biomolecules, 2020 Prion diseases are fatal, transmissible neurodegenerative disorders whose pathogenesis is driven by the misfolding, self-templating and cell-to-cell spread of the prion protein.
Hailey Pineau, Valerie Sim
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Sheep scrapie and deer rabies in England prior to 1800
Prion, 2023 Eighteenth-century England witnessed the emergence of two neurological diseases in animals. Scrapie, a transmissible spongiform encephalopathy, is a fatal neurodegenerative disease of sheep and goats that appears in classical and atypical forms.
Anthony Ness +2 more
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Pharmaceutics, 2020 Clinical symptoms of Alzheimer’s Disease (AD) include behavioral alterations and cognitive impairment. These functional phenotypes early occur in triple-transgenic (3xTg-AD) mice.
Alejandro R. Roda +3 more
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End-to-End Optimized Pipeline for Prediction of Protein Folding Kinetics [PDF]
arXiv, 2023 Protein folding is the intricate process by which a linear sequence of amino acids self-assembles into a unique three-dimensional structure. Protein folding kinetics is the study of pathways and time-dependent mechanisms a protein undergoes when it folds. Understanding protein kinetics is essential as a protein needs to fold correctly for it to perform
arxiv
BiomoleculesSlow-onset neurodegenerative disease in a low-expresser 2N4R P301L transgenic (Tg) mouse model is marked by neuroinflammation and by differing patterns of CNS deposition and accumulation of tau conformers, with such heterogeneities present even within ...
Nathalie Daude +4 more
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Controlling the folding and substrate-binding of proteins using polymer brushes [PDF]
Physical Review Letters 108 208104 (2012), 2012 The extent of coupling between the folding of a protein and its binding to a substrate varies from protein to protein. Some proteins have highly structured native states in solution, while others are natively disordered and only fold fully upon binding.
arxiv +1 more source
Disease Models & Mechanisms, 2021 Amyloid β (Aβ) peptides generated from the amyloid precursor protein (APP) play a critical role in the development of Alzheimer's disease (AD) pathology.
Qi Wu +5 more
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Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
Calcineurin inhibitors: status quo and perspectives
Biomolecular Concepts, 2011 Despite the fact that cyclosporin A (CsA) and tacrolimus (FK506) are very potent drugs in the treatment of serious autoimmune diseases and in the prevention of graft vs.
Erdmann Frank, Weiwad Matthias
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Cellular Biology of Tau Diversity and Pathogenic Conformers
Frontiers in Neurology, 2020 Tau accumulation is a prominent feature in a variety of neurodegenerative disorders and remarkable effort has been expended working out the biochemistry and cell biology of this cytoplasmic protein.
Sang-Gyun Kang +5 more
doaj +1 more source