Results 151 to 160 of about 11,990,533 (304)

LAFA: a framework for reproducible longitudinal assessment of protein function annotation models. [PDF]

Bioinform Adv
Phan A, Wang Y, Boadu F, Cheng J, Radivojac P, Friedberg I.   +5 more
europepmc   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Severe obesity in human HFpEF alters contractile protein function and organization. [PDF]

Science
Jani VP, Rhodehamel M, Fenwick AJ, Ma W, Fisher E, Giannakopoulos MT, Moon S, Castillo RL, Kennedy LM, Irving TC, Tardiff JC, Murphy E, Chaerkady R, Wang Q, Barry ME, Hahn VS, Sharma K, Margulies KB, Bedi KC, Cammarato A, Kass DA.   +20 more
europepmc   +1 more source

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source

Protein bioinformatics : from sequence to function /

, 2010
One of the most pressing tasks in biotechnology today is to unlock the function of each of the thousands of new genes identified every day. Scientists do this by analyzing and interpreting proteins, which are considered the task force of a gene.
Gromiha, M. Michael,author.
core  

Subcellular localization as a driver of protein function. [PDF]

Nat Rev Mol Cell Biol
Sigaeva A, Hutchings C, Cesnik A, Lilley KS, Lundberg E.   +4 more
europepmc   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

The monoclonal antibody M18 suppresses HIV-1 gp120 receptor interactions and envelope spike function

, 2010
Protein Structure Initiative: 2010 NIGMS Workshop: Enabling Technologies in Structure and Function, Bethesda, MD., 19-21 April ...
Schön, A, Kuriakose, SA, McFadden, K, Zhang, M, Umashankara, M, Rajagopal, S, Cocklin, S, Zentner, IJ, Contarino, M, Chaiken, IM   +9 more
core  

Modulating Protein Function through Genetically Encoded Oxidative Chemistry. [PDF]

J Am Chem Soc
Li H, Pavlič A, Ibrahim NE, Wu D, Shapiro MG.   +4 more
europepmc   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source