Results 241 to 250 of about 251,250 (306)

In silico identification of bilobetin and ginsenoside as dual CK2 and ULK2 inhibitors targeting triple-negative breast cancer. [PDF]

Sci Rep
Hossain MA, Tamanna IJ, Hossain MS, Parvez A, Afrin S, Sobuj DR, Islam MT, Al Noman A, Ahmed M, Sultana S, Srivastava S, Rao GSNK, Khan SR, Babu MR, Tariq M, Saiyad MT, Hamzah Z, Jain M.   +17 more
europepmc   +1 more source

Autophagosome marker, LC3, is released extracellularly via several distinct pathways

FEBS Open Bio, EarlyView.
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito, Masashi Arakawa, Koki Maeda, Eiji Morita   +3 more
wiley   +1 more source

Virulence on Pm4 kinase-based resistance is determined by two divergent wheat powdery mildew effectors. [PDF]

Nat Plants
Bernasconi Z, Herger AG, Caro MDP, Kunz L, Müller MC, Stirnemann U, Outram MA, Widrig V, Neidhart M, Isaksson J, Schudel S, Rösli S, Wicker T, Bender KW, Zipfel C, Dodds PN, Figueroa M, Sánchez-Martín J, Keller B.   +18 more
europepmc   +1 more source

Analysis of Treacher Collins syndrome 4‐associated mutations in Schizosaccharomyces pombe

FEBS Open Bio, EarlyView.
Fission yeast models carrying Treacher Collins syndrome type 4‐associated mutations reveal that impaired processivity of RNA polymerase I leads to defective rRNA transcription. This study highlights the essential role of a conserved arginine residue in Pol I elongation and provides mechanistic insight into the pathogenesis of ribosomopathies.
Kei Kawakami, Hiroaki Kato
wiley   +1 more source

Methods for detecting protein-protein interactions. [PDF]

Mol Cells
Cho SC, Park HW.
europepmc   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Mapping the stage-specific plasma p53 interactome reveals colorectal cancer progression signatures and therapeutic vulnerabilities. [PDF]

J Liq Biopsy
Natarajan RA, Kaliyamoorthy S, Boopathi V, Ramasamy J, Sambandam R.   +4 more
europepmc   +1 more source

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

FEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli, Enrico Landi, Francesco Maiurano, Irene Paris, Rosanna Papa, Marco Artini, Laura Selan, Stefano Borocci, Francesco Buonocore, Esther Imperlini   +9 more
wiley   +1 more source

A bi-stage data-driven process-based model for sorghum breeding and yield prediction: coupling explainable artificial intelligence and crop modeling. [PDF]

Front Plant Sci
Ni Z, Chang Y, Kemp J, Salas-Fernandez MG, Wang L.   +4 more
europepmc   +1 more source