Results 81 to 90 of about 543,220 (340)

The role of fibroblast growth factors in cell and cancer metabolism

FEBS Letters, EarlyView.
Fibroblast growth factor (FGF) signaling regulates crucial signaling cascades that promote cell proliferation, survival, and metabolism. Therefore, FGFs and their receptors are often dysregulated in human diseases, including cancer, to sustain proliferation and rewire metabolism.
Jessica Price, Chiara Francavilla
wiley   +1 more source

Application of an integrated physical and functional screening approach to identify inhibitors of the Wnt pathway

Molecular Systems Biology, 2009
Large‐scale proteomic approaches have been used to study signaling pathways. However, identification of biologically relevant hits from a single screen remains challenging due to limitations inherent in each individual approach.
Bryan W Miller, Garnet Lau, Chris Grouios, Emanuela Mollica, Miriam Barrios‐Rodiles, Yongmei Liu, Alessandro Datti, Quaid Morris, Jeffrey L Wrana, Liliana Attisano   +9 more
doaj   +1 more source

Interactive proteomics: what lies ahead?

BioTechniques, 2008
Interactive proteomics addresses the physical associations among proteins and establishes global, disease-, and pathway-specific protein interaction networks.
Bernhard Suter, Saranya Kittanakom, Igor Stagljar   +2 more
doaj   +1 more source

Do peers see more in a paper than its authors? [PDF]

, 2012
Recent years have shown a gradual shift in the content of biomedical publications that is freely accessible, from titles and abstracts to full text. This has enabled new forms of automatic text analysis and has given rise to some interesting questions ...
Divoli, Anna, Hearst, Marti, Nakov, Preslav   +2 more
core   +3 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

A first-draft human protein-interaction map [PDF]

Genome Biology, 2004
Abstract Background Protein-interaction maps are powerful tools for suggesting the cellular functions of genes. Although large-scale protein-interaction maps have been generated for several invertebrate species, projects of a similar scale have not yet been described for any mammal.
Lehner, Ben, Fraser, Andrew G
openaire   +2 more sources

Mapping genetic interactions in cancer: a road to rational combination therapies. [PDF]

, 2019
The discovery of synthetic lethal interactions between poly (ADP-ribose) polymerase (PARP) inhibitors and BRCA genes, which are involved in homologous recombination, led to the approval of PARP inhibition as a monotherapy for patients with BRCA1/2 ...
Krogan, Nevan J, Tutuncuoglu, Beril
core  

Realistic protein-protein association rates from a simple diffusional model neglecting long-range interactions, free energy barriers, and landscape ruggedness

, 2004
We develop a simple but rigorous model of protein-protein association kinetics based on diffusional association on free energy landscapes obtained by sampling configurations within and surrounding the native complex binding funnels.
Camacho, David Baker, Debye, Ermak, Gabdoulline, Gabdoulline, Gabdoulline, Gray, Janin, Maximilian Schlosshauer, Northrup, Schlosshauer, Schreiber, Selzer, Shoup, Smoluchowski, Vijayakumar, Zhou   +17 more
core   +2 more sources

Data-driven network alignment

, 2020
Biological network alignment (NA) aims to find a node mapping between species' molecular networks that uncovers similar network regions, thus allowing for transfer of functional knowledge between the aligned nodes.
Gu, Shawn, Milenkovic, Tijana
core   +1 more source

Allo-network drugs: Extension of the allosteric drug concept to protein-protein interaction and signaling networks [PDF]

, 2013
Allosteric drugs are usually more specific and have fewer side effects than orthosteric drugs targeting the same protein. Here, we overview the current knowledge on allosteric signal transmission from the network point of view, and show that most ...
Csermely, Péter, Nussinov, Ruth, Szilágyi, András   +2 more
core   +2 more sources