Results 71 to 80 of about 7,803,058 (302)

Illuminating spatial and temporal organization of protein interaction networks by mass spectrometry-based proteomics

Frontiers in Genetics, 2015
Protein-protein interactions are at the core of all cellular functions and dynamic alterations in protein interactions regulate cellular signaling. In the last decade, mass spectrometry-based proteomics has delivered unprecedented insights into human ...
Jiwen eYang, Sebastian Alexander Wagner, Petra eBeli   +2 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

From nonspecific DNA-protein encounter complexes to the prediction of DNA-protein interactions. [PDF]

PLoS Computational Biology, 2009
DNA-protein interactions are involved in many essential biological activities. Because there is no simple mapping code between DNA base pairs and protein amino acids, the prediction of DNA-protein interactions is a challenging problem. Here, we present a
Mu Gao, Jeffrey Skolnick
doaj   +1 more source

Structural and Evolutionary Insights Into the Binding of Host Receptors by the Rabies Virus Glycoprotein

Frontiers in Cellular and Infection Microbiology, 2021
Rabies represents a typical model for spillover of zoonotic viral diseases among multiple hosts. Understanding the success of rabies virus (RV) in switching hosts requires the analysis of viral evolution and host interactions.
Manar E. Khalifa, Manar E. Khalifa, Leonie Unterholzner, Muhammad Munir   +3 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

SLIDER: Mining correlated motifs in protein-protein interaction networks [PDF]

, 2009
—Correlated motif mining (CMM) is the problem to find overrepresented pairs of patterns, called motif pairs, in interacting protein sequences. Algorithmic solutions for CMM thereby provide a computational method for predicting binding sites for protein ...
Boyen, P., Dijk, A.D.J., van, Ham, R.C.H.J., van, Neven, F.   +3 more
core  

Genetic interaction mapping of Aurora protein kinases in mouse oocytes

Frontiers in Cell and Developmental Biology
The Aurora Kinases (AURKs) are a family of serine-threonine protein kinases critical for cell division. Somatic cells express only AURKA and AURKB. However, mammalian germ cells and some cancer cells express all three isoforms.
Cecilia S. Blengini, Cecilia S. Blengini, Karen Schindler, Karen Schindler   +3 more
doaj   +1 more source

Simple Ligand–Receptor Interaction Descriptor (SILIRID) for alignment-free binding site comparison

Computational and Structural Biotechnology Journal, 2014
We describe SILIRID (Simple Ligand–Receptor Interaction Descriptor), a novel fixed size descriptor characterizing protein–ligand interactions. SILIRID can be obtained from the binary interaction fingerprints (IFPs) by summing up the bits corresponding to
Vladimir Chupakhin, Gilles Marcou, Helena Gaspar, Alexandre Varnek   +3 more
doaj   +1 more source

Landscape mapping of functional proteins in insulin signal transduction and insulin resistance: a network-based protein-protein interaction analysis. [PDF]

PLoS ONE, 2011
The type 2 diabetes has increased rapidly in recent years throughout the world. The insulin signal transduction mechanism gets disrupted sometimes and it's known as insulin-resistance. It is one of the primary causes associated with type-2 diabetes.
Chiranjib Chakraborty, Sanjiban S Roy, Minna J Hsu, Govindasamy Agoramoorthy   +3 more
doaj   +1 more source

Bromodomain protein BRD8 regulates cell cycle progression in colorectal cancer cells through a TIP60-independent regulation of the pre-RC complex

iScience, 2023
Summary: Bromodomain-containing protein 8 (BRD8) is a subunit of the NuA4/TIP60-histone acetyltransferase complex. Although BRD8 has been considered to act as a co-activator of the complex, its biological role remains to be elucidated. Here, we uncovered
Kiyoshi Yamaguchi, Saya Nakagawa, Akari Saku, Yumiko Isobe, Rui Yamaguchi, Paul Sheridan, Kiyoko Takane, Tsuneo Ikenoue, Chi Zhu, Masashi Miura, Yuya Okawara, Satoru Nagatoishi, Hiroko Kozuka-Hata, Masaaki Oyama, Susumu Aikou, Yuka Ahiko, Dai Shida, Kouhei Tsumoto, Satoru Miyano, Seiya Imoto, Yoichi Furukawa   +20 more
doaj   +1 more source