Results 81 to 90 of about 271,486 (262)

Quantitative Interaction Proteomics of Neurodegenerative Disease Proteins

Cell Reports, 2015
Several proteins have been linked to neurodegenerative disorders (NDDs), but their molecular function is not completely understood. Here, we used quantitative interaction proteomics to identify binding partners of Amyloid beta precursor protein (APP) and
Fabian Hosp, Hannes Vossfeldt, Matthias Heinig, Djordje Vasiljevic, Anup Arumughan, Emanuel Wyler, Markus Landthaler, Norbert Hubner, Erich E. Wanker, Lars Lannfelt, Martin Ingelsson, Maciej Lalowski, Aaron Voigt, Matthias Selbach   +13 more
doaj   +1 more source

Development and application of high throughput hydrogen deuterium exchange mass spectrometry for characterizing protein interactions in complex biological samples

, 2023
Protein interactions (e.g., protein-protein interactions and protein-ligand interactions) play an important role in regulating the numerous biological processes that dictate cellular activity. The characterization of protein interactions in their native,
Fang, Mulin
core  

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Homologous mapping yielded a comprehensive predicted protein–protein interaction network for peanut (Arachis hypogaea L.)

BMC Plant Biology
Background Protein–protein interactions are the primary means through which proteins carry out their functions. These interactions thus have crucial roles in life activities.
Fangping Gong, Di Cao, Xiaojian Sun, Zhuo Li, Chengxin Qu, Yi Fan, Zenghui Cao, Kai Zhao, Kunkun Zhao, Ding Qiu, Zhongfeng Li, Rui Ren, Xingli Ma, Xingguo Zhang, Dongmei Yin   +14 more
doaj   +1 more source

Backbone dynamics of complement control protein (CCP) modules reveals mobility in binding surfaces

, 2004
The regulators of complement activation (RCA) are critical to health and disease because their role is to ensure that a complement-mediated immune response to infection is proportionate and targeted.
Krystyna Bromek, Uhrin, D, O'Leary, JM, Xuefeng Wang, Stanislava Uhrinova, Joanne M. O'Leary, Black, GM, Wang, XF, Malgorzata Krych, John P. Atkinson, Uhrinova, S, Dusan Uhrin, Atkinson, JP, Gordon M. Black, Krych, M, Schmitz, C, Paul N. Barlow, Bromek, K, Barlow, PN, Christian Schmitz   +19 more
core   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Domain-based prediction of the human isoform interactome provides insights into the functional impact of alternative splicing.

PLoS Computational Biology, 2017
Alternative splicing is known to remodel protein-protein interaction networks ("interactomes"), yet large-scale determination of isoform-specific interactions remains challenging.
Mohamed Ali Ghadie, Luke Lambourne, Marc Vidal, Yu Xia   +3 more
doaj   +1 more source

Functional mapping of the fission yeast DNA polymerase delta B-subunit Cdc1 by site-directed and random pentapeptide insertion mutagenesis [PDF]

, 2009
JSG was supported by a BBSRC Research Committee studentship, EVK by the Darwin Trust of Edinburgh, and FCG and SAM by a Wellcome Trust Senior Research Fellowship in Basic Biomedical Sciences.
Garcia, JS, MacNeill, Stuart Andrew, Knatko, EV, Gray, FC, Tahirov, TH, Baranovskiy, AG   +5 more
core   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Two Rules on the Protein-Ligand Interaction

, 2008
So far, we still lack a clear molecular mechanism to explain the protein-ligand interaction on the basis of electronic structure of a protein. By combining the calculation of the full electronic structure of a protein along with its hydrophobic pocket ...
Lily Zhang, Xinyi Zhang, Xiaodong Pang, Linxiang Zhou, Lina Xu   +4 more
core