Results 101 to 110 of about 441,552 (301)

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Rab3D is critical for secretory granule maturation in PC12 cells.

, 2013
Neuropeptide- and hormone-containing secretory granules (SGs) are synthesized at the trans-Golgi network (TGN) as immature secretory granules (ISGs) and complete their maturation in the F-actin-rich cell cortex.
Sharon A. Tooze (391543), Kögel Tanja, Copier, J., Hodneland, E, Gerdes, HH, Gerdes Hans-Hermann, Tooze, S. A., Tooze Sharon A., Copier, J, Rüdiger Rudolf (151449), Tanja Kögel, Romano Regazzi, Rudolf Rüdiger, Copier John, Gerdes, H. H., Tooze, SA, Tanja Kögel (391540), Kögel, T., Hans-Hermann Gerdes, Kögel, T, Hodneland Erlend, John Copier, Tooze, S.A., Rudolf, R., Regazzi Romano, Regazzi, R, Erlend Hodneland, Gerdes, H.H., Erlend Hodneland (391541), Regazzi, R., Sharon A Tooze, Hodneland, E., John Copier (391542), Rudolf, R, Romano Regazzi (210061), Rüdiger Rudolf, Hans-Hermann Gerdes (127873)   +36 more
core   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

SETMAR isoforms in glioblastoma: A matter of protein stability

Oncotarget, 2016
Glioblastomas (GBMs) are the most frequent and the most aggressive brain tumors, known for their chemo- and radio-resistance, making them often incurable. We also know that SETMAR is a protein involved in chromatin dynamics and genome plasticity, of which overexpression confers chemo- and radio-resistance to some tumors.
Dussaussois-Montagne, Audrey, Jaillet, Jérôme, Babin, Laetitia, Verrelle, Pierre, Karayan-Tapon, Lucie, Renault, Sylvaine, Rousselot-Denis, Cécilia, Zemmoura, Ilyess, Augé-Gouillou, Corinne   +8 more
openaire   +3 more sources

Cloning and characterization of two osmotin isoforms from Piper colubrinum

, 2010
In the present study, we report the cloning and sequence characterization of two isoforms of osmotin, an antifungal PR-5 gene homologue, from a salicylic acid-induced subtracted cDNA library earlier generated in Piper colubrinum.
S. Manjula, T. Mani
core   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

The complex of TRIP-Br1 and XIAP ubiquitinates and degrades multiple adenylyl cyclase isoforms

eLife, 2017
Adenylyl cyclases (ACs) generate cAMP, a second messenger of utmost importance that regulates a vast array of biological processes in all kingdoms of life.
Wenbao Hu, Xiaojie Yu, Zhengzhao Liu, Ying Sun, Xibing Chen, Xin Yang, Xiaofen Li, Wai Kwan Lam, Yuanyuan Duan, Xu Cao, Hermann Steller, Kai Liu, Pingbo Huang   +12 more
doaj   +1 more source

Kallikrein-Related Peptidase (KLK) family mRNA variants and protein isoforms in hormone-related cancers : do they have a function?

, 2006
The kallikrein-related peptidase (KLK) gene family of 15 serine proteases encodes many proteins, including prostate specific antigen (PSA or KLK3), that are well described and/or are potential biomarkers for hormone-related cancers.
Whitbread, Astrid, Dong, Ying, Tan, Olivia, Clements, Judith   +3 more
core   +1 more source

Acute Ethanol Administration Rapidly Increases Phosphorylation of Conventional Protein Kinase C in Specific Mammalian Brain Regions in Vivo [PDF]

, 2007
Background Protein kinase C (PKC) is a family of isoenzymes that regulate a variety of functions in the central nervous system including neurotransmitter release, ion channel activity, and cell differentiation.
Morrow, A. Leslie, Besheer, Joyce, Sandeep Kumar, A. Leslie Morrow, O'Buckley, Todd K., Kumar, Sandeep, Todd K. O'Buckley, Clyde W. Hodge, Stephen P. Kelley, Joyce Besheer, Wilkie, Mary Beth, Hodge, Clyde W., Mary Beth Wilkie, Kelley, Stephen P.   +13 more
core   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source