Advanced Healthcare Materials, EarlyView.Sweetosomes, a new class of fucose‐decorated liposomes, are developed via a one‐step microfluidic process without surface chemistry. This study elucidates their main caveolae‐mediated entry and distinct endosomal trafficking. These nanostructures demonstrate superior endosomal escape, organelle acidity modulation, and prolonged plasma persistence ...
Mattia Tiboni +13 more
wiley +1 more source
Characterizing the Protein Isoforms of foraging (for), the PKGI Ortholog in Drosophila melanogaster. [PDF]
Int J Mol Sci, 2023 Vasquez OE +6 more
europepmc +1 more source
Matrix Stiffness Directs Stemness Signatures in Breast Cancer
Advanced Healthcare Materials, EarlyView.We built lab‐grown breast cancer models to study how the stiffness of the tumor's surroundings influences cancer behavior. Softer environments encouraged more stem‐like, drug‐resistant cells, while stiffer ones kept cells more differentiated. These findings show that tissue mechanics drive cancer diversity and drug resistance, offering new insights for
Chantal Kopecky +4 more
wiley +1 more source
Genome BiologyBackground Neuropsychiatric disorders are highly complex conditions and the risk of developing a disorder has been tied to hundreds of genomic variants that alter the expression and/or RNA isoforms made by risk genes.
Ricardo De Paoli-Iseppi +15 more
doaj +1 more source
Correction: Molecular modelling of the HCMV IL-10 protein isoforms and analysis of their interaction with the human IL-10 receptor. [PDF]
PLoS One, 2023 Pantaleão SQ +10 more
europepmc +1 more source
The fixation of complement protein pairs to CR2 isoforms
Biochemistry and Biophysics ReportsReviewing old protocols, it was found that Raji, a CR2-posistive cell line, binds both endogenous (e-C3) and exogenous C3 (i-C3). The processing of i-C3 to an i-C3b-like protein and their fixation to CR2 isoforms resulted in the formation of heterodimers whose units might be linked via thioester by low m.w. molecule(s).
openaire +3 more sources
Cell Adhesion by Design: Engineering Tissue Culture Scaffolds With Adhesion Cues
Advanced Materials Interfaces, EarlyView.ABSTRACT In scaffold‐based tissue engineering, the matrix should provide adequate adhesion cues for cell attachment, spreading, and function. Given the multitude of adhesion receptors and the diversity of scaffolds, there are many approaches to render scaffolds adhesive, even though they are not all equivalent.
Dalia Dranseike +3 more
wiley +1 more source
C-reactive protein isoforms as prognostic markers of COVID-19 severity. [PDF]
Front Immunol, 2022 Molins B +8 more
europepmc +1 more source
QBP1 Peptide as a Potential Anti‐Amyloidogenic Therapy for Type 2 Diabetes: An In Vitro Study
Advanced Science, EarlyView.The anti‐amyloidogenic peptide QBP1 effectively halts human islet amyloid polypeptide (hIAPP) aggregation, preventing the formation of toxic β‐structured intermediates. Through a combination of biophysical assays, molecular dynamics, and cell‐based studies, QBP1 is shown to preserve β‐cell viability and metabolic homeostasis, positioning it as a ...
María M. Tejero‐Ojeda +8 more
wiley +1 more source
MED19 encodes two unique protein isoforms that confer prostate cancer growth under low androgen through distinct gene expression programs. [PDF]
Sci Rep, 2023 Ruoff R +6 more
europepmc +1 more source