Results 201 to 210 of about 648,804 (352)

Lithium‐Charged Gold Nanoparticles: A New Powerful Tool for Lithium Delivery and Modulation of Glycogen Synthase Kinase 3 Activity

Advanced Materials, EarlyView.
This study introduces glutathione‐stabilized gold nanoparticles for targeted lithium delivery (LiG‐AuNPs), enabling the controlled modulation of Glycogen Synthase Kinase‐3 (GSK‐3β). These non‐toxic, 2‐nm particles release lithium intracellularly, effectively inhibiting GSK‐3β in the brain without significant plasma lithium alterations.
Antonio Buonerba, Giulia Puliatti, Domenica Donatella Li Puma, Bruno Bandiera, Beatrice Cannata, Maria Elena Marcocci, Nicolina Castagno, Irene Contento, Salvatore Impemba, Mariarosa Scognamiglio, Rocco Di Girolamo, Vincenzo Naddeo, Patrizia Canton, Carmine Capacchione, Laura Sposito, Martina Albini, Francesco Pastore, Silvia Baroni, Alfonso Grassi, Claudio Grassi, Roberto Piacentini   +20 more
wiley   +1 more source

Unveiling the Metal-Dependent Aggregation Properties of the C-terminal Region of Amyloidogenic Intrinsically Disordered Protein Isoforms DPF3b and DPF3a. [PDF]

Int J Mol Sci, 2022
Leyder T, Mignon J, Mottet D, Michaux C.
europepmc   +1 more source

Cardiac fatty acid-binding proteins. Isolation and characterization of the mitochondrial fatty acid-binding protein and its structural relationship with the cytosolic isoforms.

, 1990
C. Unterberg, Torsten Börchers, Peter Højrup, Peter Roepstorff, J Knudsen, Friedrich Spener   +5 more
openalex   +1 more source

Quantitative Assessment of Gut and Vascular Barriers in TTOP, a Cartridge‐Based Bicompartmental Culture Platform

Advanced Materials Technologies, EarlyView.
The modular, versatile, and standardized cartridge‐based culture module allows to replicate gut and vascular barriers. Its conventional handling requirements facilitate adoption by non‐technical users, while the design allows safe manipulation and retrieval of samples for permeability assays and endpoint analysis.
Lorenzo Pietro Coppadoro, Maria Lombardi, Sabrina Nicolò, Alessandra Maria Anna Rando, Gianfranco Beniamino Fiore, Chiara Foglieni, Monica Soncini   +6 more
wiley   +1 more source

Roles of Specific Isoforms of Protein Kinase C in the Transcriptional Control of Cyclin D1 and Related Genes

, 2003
Jae‐Won Soh, I. Bernard Weinstein
openalex   +1 more source

Heat Sensitivity in a Bentgrass Variant. Failure to Accumulate a Chloroplast Heat Shock Protein Isoform Implicated in Heat Tolerance [PDF]

, 2003
Dongfang Wang, Dawn S. Luthe
openalex   +1 more source

DKK3 Initially Preserves Acinar Integrity Through MEK‐Fos Signaling, but Later Switches to an Oncogenic Role in Pancreatic Cancer

Advanced Science, EarlyView.
In pancreatic cancer, the protein DKK3 is found to play a complex role: it initially slows early tumor growth but later promotes tumor aggressiveness. DKK3 expression evolves during progression and drives cancer severity by orchestrating cellular and molecular signaling pathways.
Dharini Srinivasan, Elodie Roger, Lukas Perkhofer, Eleni Zimmer, Thomas F.E. Barth, Julia P. Mosler, Anna Härle, Stephanie E. Weissinger, Nadine T. Gaisa, Peter Möller, Nico Fischer, Chantal Allgöwer, J.‐Matthias Löhr, Dirk Grimm, Thomas Seufferlein, Stefan Liebau, Ninel Azoitei, Michael K. Melzer, Frank Arnold, Johann Gout, Alexander Kleger   +20 more
wiley   +1 more source

Prediagnostic Serum Vitamin D, Vitamin D Binding Protein Isoforms, and Cancer Survival. [PDF]

JNCI Cancer Spectr, 2022
Weinstein SJ, Mondul AM, Layne TM, Yu K, Huang J, Stolzenberg-Solomon RZ, Ziegler RG, Purdue MP, Huang WY, Abnet CC, Freedman ND, Albanes D.   +11 more
europepmc   +1 more source

CircPVT1 Promotes Lung Metastasis and Tumor Progression in Renal Cell Carcinoma by Encoding the cP104aa Peptide and Targeting EIF4A3

Advanced Science, EarlyView.
This study reveals that circPVT1 promotes the renal cell carcinoma lung metastasis and tumor progression through encoding the cP104aa peptide and directly binds with EIF4A3, which jointly regulates the target gene c‐MYC. Abstract Circular RNA (circRNA) plays a pivotal role in the pathogenesis of renal cell carcinoma (RCC).
Houliang Zhang, Tao Tao, Jie Ji, Tonglei Zhao, Si Sun, Lijie Zhang, Jianping Wu, Ming Chen, Shuqiu Chen, Bin Xu, Weipu Mao   +10 more
wiley   +1 more source

The Pathogenic Roles of Local Vitamin D Metabolism Defect in Valve Inflammation and Calcification

Advanced Science, EarlyView.
This study identifies the valvular interstitial cell populations responsible for valvular calcification induced by hyperphosphatemia and likely aging, uncovers local vitamin D metabolism defect‐induced inflammation as a critical pathogenic factor of calcific aortic valve disease, and highlights active vitamin D and ERK inhibitor as potential preventive
Ruichen Yang, Chong Han, Yangli Xie, Shoutao Qiu, Shaoyang Zhang, Jingjia He, Zejian Wang, Zhenlin Zhang, Huijuan Liu, Lin Chen, Baojie Li   +10 more
wiley   +1 more source